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个人简介

孔炜教授,北京大学医学部生理与病理生理系主任。教育部长江学者;基金委杰出青年基金获得者;“万人计划领军人才”入选者,基金委创新群体带头人。

研究领域

血管微环境与重大心血管疾病

近期论文

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Yang L, Dai R, Wu H, Cai Z, Xie N, Zhang X, Shen Y, Gong Z, Jia Y, Yu F, Zhao Y, Lin P, Ye C, Hu Y, Fu Y, Xu Q, Li Z, Kong W. Unspliced XBP1 Counteracts β-catenin to Inhibit Vascular Calcification. Circ Res. 2022 Jan 21;130(2):213-229. Fu Y, Huang Y, Yang Z, Chen Y, Zheng J, Mao C, Li Z, Liu Z, Yu B, Li T, Wang M, Xu C, Zhou Y, Zhao G, Jia Y, Guo W, Jia X, Zhang T, Li L, Liu Z, Guo S, Ma M, Zhang H, Liu B, Du J, Wang W, Tang C, Gao P, Xu Q, Wang X, Liu J, Sun J, Kong W. Cartilage oligomeric matrix protein is an endogenous beta-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury. Cell Res. 2021 Jul;31(7):773-790. Mao C, Ma Z, Jia Y, Li W, Xie N, Zhao G, Ma B, Yu F, Sun J, Zhou Y, Cui Q, Fu Y, Kong W.Nidogen-2 Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells and Prevents Neointima Formation via Bridging Jagged1-Notch3 Signaling. Circulation. 2021 Oct 12;144(15):1244-1261. Wang Y, Chen D, Zhang Y, Wang P, Zheng C, Zhang S, Yu B, Zhang L, Zhao G, Ma B, Cai Z, Xie N, Huang S, Liu Z, Mo X, Guan Y, Wang X, Fu Y, Ma D, Wang Y, and Kong W. A Novel Adipokine, FAM19A5, Inhibits Postinjury Neointima Formation through Sphingosine-1-Phosphate Receptor 2. Circulation 2018 Jul 3;138(1):48-63. Li T, Yu B, Liu Z, Li J, Ma M, Wang Y, Zhu M, Yin H, Wang X, Fu Y, Yu F, Wang X, Fang X, Sun J, Kong W. Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury. Nat Commun 2018 Jan 2;9(1):11 Li Z, Zhao Z, Cai Z, Sun Y, Li L, Yao F, Yang L, Zhou Y, Zhu H, Fu Y, Wang L, Fang W, Chen Y, Kong W*. Runx2 (Runt-Related Transcription Factor 2)-Mediated Microcalcification Is a Novel Pathological Characteristic and Potential Mediator of Abdominal Aortic Aneurysm. Arterioscler Thromb Vasc Biol. 2020 May;40(5):1352-1369. Wang Y, Chen D, Zhang Y, Wang P, Zheng C, Zhang S, Yu B, Zhang L, Zhao G, Ma B, Cai Z, Xie N, Huang S, Liu Z, Mo X, Guan Y, Wang X, Fu Y, Ma D, Wang Y, and Kong W*. A Novel Adipokine, FAM19A5, Inhibits Postinjury Neointima Formation through Sphingosine-1-Phosphate Receptor 2. Circulation 2018 Feb 16. [Epub ahead of print] Li T, Yu B, Liu Z, Li J, Ma M, Wang Y, Zhu M, Yin H, Wang X, Fu Y, Yu F, Wang X, Fang X, Sun J, Kong W*. Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury. Nat Commun 2017 2018 Jan 2;9(1):11 Zhao G, Fu Y, Cai Z, Yu F, Gong Z, Dai R, Hu Y, Zeng L, Xu Q, Kong W*. Unspliced XBP1 Confers VSMC Homeostasis and Prevents Aortic Aneurysm Formation via FoxO4 Interaction. Circ Res. 2017 Dec 8;121(12):1331-1345 Yu B, Liu Z, Fu Y, Wang Y, Zhang L, Cai Z, Yu F, Wang X, Zhou J, Kong W*. CYLD Deubiquitinates Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 Contributing to Adventitial Remodeling. Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):1698-1709. Kong W, Du J, Zhu Y, Dong E. Basic and Translational Vascular Research in China: Past, Present, and Future. Circ Res. 2017 Aug 4;121(4):335-337. Fu Y, Gao C, Liang Y, Wang M, Huang Y,Ma W,Li T,Jia Y,Yu F,Zhu W,Cui Q,Li Y,Xu Q,Wang X, Kong W*. Shift of Macrophage Phenotype due to Cartilage Oligomeric Matrix Protein Deficiency Drives Atherosclerotic Calcification Circ. Res. 2016 Jul 8;119(2):261-76 (Cover story with editorial comment) Gao C, Fu Y, Li Y, Zhang X, Zhang L, Yu F, Xu S, Xu Q, Zhu Y, Guan Y, Wang X, Kong W* Microsomal Prostaglandin E Synthase-1-Derived PGE2 Inhibits Vascular Smooth Muscle Cell Calcification. Arterioscler Thromb Vasc Biol. 2016 Jan;36(1):108-21 Liang Y, Fu Y, Qi R, Wang M, Yang N, He L, Yu F, Zhang J, Yun CH, Wang X, Liu J, Kong W*. Cartilage oligomeric matrix protein is a natural inhibitor of thrombin. Blood. 2015 Aug 13;126(7):905-14 (with editorial comment) Kessler T, Zhang L, Liu Z, Yin X, Huang Y, Wang Y, Fu Y, Mayr M, Ge Q, Xu Q, Zhu Y, Wang X, Schmidt K, de Wit C, Erdmann J, Schunkert H, Aherrahrou Z, Kong W*. ADAMTS-7 Inhibits Re-Endothelialization of Injured Arteries and Promotes Vascular Remodeling Via Cleavage of Thrombospondin-1. Circulation. 2015 Mar 31;131(13):1191-201(with editor)

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