周专 - 北京大学 - Idg/麦戈文大脑研究所

个人简介

1984年获同济大学电子仪器与测量技术（5年制）专业学士学位；1990年获华中科技大学生物医学工程博士学位；1990-1993德国马普生物物理化学研究所Erwin Neher（1991年诺贝尔奖得主）实验室博士后；1993-1995年美国华盛顿大学生理和医学系讲师；1995-1997美国芝加哥Loyola大学生理系研究助理教授；1993-2000华中科技大学生物物理与化学研究所所长、教授；1997-1999中国科技大学神经与生物物理系常务副主任、教授；1999-2004上海中国科学院神经科学研究所研究员、实验室主任。2005起任北京大学分子医学研究所教授、高级研究员。

研究领域

细胞的分泌是细胞最基本的一个功能。细胞内钙离子的升高将引起神经递质和激素的分泌。我们研究分泌的分子和细胞机制，以及多巴胺分泌生理学及其与神经退行性疾病的关系。使用膜片钳、膜电容、微碳纤电极以及共聚焦、多光子荧光显微成像在活体（in vivo）、组织（brain slices）、单细胞水平测量检测量子化神经递质、激素(特别是儿茶酚胺类)分泌信号。

近期论文

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1. Wang CH, Kang XJ, Zhou L, Chai ZY, Wu QH, Huang R, Xu HD, Hu MQ, Sun XX, Sun SH, Li J, Jiao RY, Zuo PL, Zheng LH, Yue ZY, and Zhou Z*. Synaptotagmin-11 is a critical mediator of parkin linked neurotoxicity and Parkinson’s Disease-like pathology. Nature Communications, 2018,9(1):81. 2. Chai ZY, Wang CH, Huang R, Wang Y, Zhang XY, Wu QH, Wang YS, Wu X, Zheng LH, Zhang C, Guo W, Xiong W, Ding JP, Zhu FP, and Zhou Z*. CaV2.2 Gates Calcium-Independent but Voltage-Dependent Secretion in Mammalian Sensory Neurons. Neuron, 2017, 96(6):1317-1326. 3. Wang Y, Wu Q, Hu M, Liu B, Chai Z, Huang R, Wang Y, Xu H, Zhou L, Zheng L, Wang C, Zhou Z*. Ligand- and voltage-gated Ca2+ channels differentially regulate the mode of vesicular neuropeptide release in mammalian sensory neurons. Science Signaling, 2017, 10(484):1-7. 4. Shang SJ, Zhu FP, Liu B, Chai ZY, Wu QH, Hu MQ, Wang Y, Huang R, Zhang ZY, Wu X, Sun L, Wang YS, Wang L, Xu HD, Teng SS, Liu B, Zheng LH, Zhang C, Zhang FK, Feng XH, Zhu DS, Wang CH, Liu T, Zhu MX, and Zhou Z*. Intracellular TRPA1 mediates Ca2+ release from lysosomes in dorsal root ganglion neurons. J Cell Biol, 2016, 215(3):369-381. 5. Wang CH, Wang YS, Hu MQ, Chai ZY, Wu QH, Huang R, Han WP, Zhang CX and Zhou Z. A synaptotagmin negatively regulates dynamin dependent clathrin-mediated and bulk endocytosis. EMBO Reports, 2016, 17(1), 47-63. 6. Shang CF, Li XQ, Yin C, Liu B, Wang YF, Zhou Z*, Du JL. Amperometric Monitoring of Sensory-Evoked Dopamine Release in Awake Larval Zebrafish. J Neurosci, 2015, 35(46):15291-4. 7.He LL, Zhang QF, Wang LC, Dai JX, Wang CH, Zheng LH, Zhou Z*. Muscarinic inhibition of nicotinic transmission in rat sympathetic neurons and adrenal chromaffin cells. Philos Trans R Soc Lond B Biol Sci, 2015, 370(1672). 8. Dou H, Wang C, Wu X, Yao L, Zhang X, Teng S, Xu H, Liu B, Wu Q, Zhang Q, Hu M, Wang Y, Wang L, Wu Y, Shang S, Kang X, Zheng L, Zhang J, Raoux M, Lang J, Li Q, Su J, Yu X, Chen L and Zhou Z*. Calcium influx activates local adenylyl cyclase 8 for sustained insulin secretion in rat pancreatic β cells. Diabetologia, 2015, 58(2):324-33. 9. Kang, X., H. Xu, S. Teng, X. Zhang, Z. Deng, L. Zhou, P. Zuo, B. Liu, Q. Wu, L. Wang, M. Hu, H. Dou, W. Liu, F. Zhu, Q. Li, S. Guo, J. Gu, Q. Lei, J. Lu, Y. Mu, M. Jin, S. Wang, W. Jiang, K. Liu, C. Wang, W. Li, K. Zhang, and Z. Zhou*. Dopamine release from transplanted neural stem cells in Parkinsonian rat striatum in vivo. Proc Natl Acad Sci USA, 2014, 111:15804-9. 10. Wang L, Xu HD, Zhou L, Jiao RY, Liu W, Zhu FP, Kang XJ, Zhang XY, Liu B, Teng SS, Wu QH, Li ML, Dou HQ, Wang CH, Zuo PL, Wang SR and Zhou Z*. Temporal components of synapse-synapse transmission in dorsal striatum brain slices. Journal of Physiology, 2014, 592:3559–3576. 11. Wang L, Shang SJ, Kang XJ , Teng SS, Zhu FP, Liu B, Wu QH, Li ML, Liu W, Xu HD, Zhou L, Jiao RY, Dou HQ, Zuo PL, Zhang XY, Zheng LH, Wang SR, Wang CH and Zhou Z*. A mechanism of modulating dopamine release in the striatum by smoking-level nicotine. Nature Communications, 2014, 5:3925. 12. Chen XW, Feng YQ, Hao CJ, Guo XL, He X, Zhou ZY, Guo N, Huang HP, Xiong W, Zheng H, Zuo PL, Zhang CX, Li W, Zhou Z*. A Schizophrenia-Susceptible Gene Affects Quanta Size of Transmitter Release. J Cell Biol, 2008, 181: 791-801. 13. Mu Y, Guo N, Fan SY, Wang SR, Huang W, Zheng LH, Li LH, Hu ZA, Zhou Z*. Hypocretin-1 potentiates NMDA receptor-mediated somatodendritic secretion from locus coeruleus neurons. J. Neurosci. , 2008, 28:3202-08. 14. Huang HP, Wang SR, Yao W, Zhang C, Zhou Y, Zhang B, Xiong W, Chen XW, Zheng LH, Wang LY, Marc Landry, Hokfelt T, Xu ZQD and Zhou Z*. Long latency of evoked quantal transmitter release from somata of locus coeruleus neurons in rat pontine slices. Proc Natl Acad Sci USA.,2007, 104(4):1401-1406. 15. Chen XK, Wang LC, Zhou Y, Zheng LH and Zhou Z*. “Kiss-and-Run” Glutamate Secretion in Cultured and Freshly Isolated Rat Hippocampal Astrocytes. J. Neurosci., 2005, 25(40):9236 –9243. 16. Chen XK, Wang LC, Zhou Y, Cai Q, Prakriya M, Duan KL, Sheng ZH, Lingle C, Zhou Z*. Activation of GPCRs modulates quantal size in chromaffin cells through Gbc and PKC. Nature Neuroscience, 2005, 8(9):1160 - 1168. 17.Zhang C, Xiong W, Zheng H, Wang L, Lu B and Zhou Z*. Calcium- and dynamin-independent endocytosis in dorsal root ganglion neurons. Neuron, 2004, 42: 225–236. 18.Yu X, Duan KL, Shang CF, Yu HG and Zhou Z*. Calcium influx through hyperpolarization-activated cation channels ( Ih channels) contributes to activity-evoked neuronal secretion. Proc Natl Acad Sci USA., 2004, 101:1051-1056. 19.Duan KL, Yu X, Zhang C, and Zhou Z*. Control of Secretion by Temporal Patterns of Action Potentials in Adrenal Chromaffin Cells. J. Neurosci., 2003, 23(35):11235-43. 20.Zhang C and Zhou Z*.Ca(2+)-independent but voltage-dependent secretion in mammalian dorsal root ganglion neurons. Nat Neurosci..2002, 5(5): p. 425-30.