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个人简介

1994年 毕业于山东泰山医学院临床医学专业,获医学学士学位; 1998年毕业于同济医科大学实验医学研究中心,获硕士学位; 2001年于中国协和医科大学阜外心血管病研究所获理学博士学位并留校工作两年。 2004-2006年在美国田纳西大学卫生科学中心生理系作博士后研究并晋升为研究助理。 自2007年2月任北京大学分子医学研究所副研究员

研究领域

心血管疾病相关基因的功能研究

近期论文

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Yang F, Zhou L, Wang Q, You X, Li Y, Zhao Y, Han X, Chang Z, He X, Cheng C, et al. NEXN inhibits GATA4 and leads to atrial septal defects inmice and humans. Cardiovascular Research. 2014;(2):228-237. SCI被引用次数:16. Hu F-Y, Wu C, Li Y, Xu K, Wang W-J, Cao H, Tian X-L. AGGF1 is a novel anti-inflammatory factor associated with TNF-α-induced endothelial activation. Cellular Signalling [Internet]. 2013;(8):1645-165. 访问链接 SCI被引用次数:33. Zeng Y, Cheng L, Zhao L, Tan Q, Feng Q, Chen H, Shen K, Li J, Zhang F, Cao H, et al. Interactions between Social/ behavioral factors and ADRB2 genotypes may be associated with health at advanced ages in China. BMC Geriatrics [Internet]. 2013;(1). 访问链接 SCI被引用次数:6. Yang F, Wu M, Li Y, Zheng G-Y, Cao H-Q, Sun W, Yang R, Zhang H, Sheng Y-H, Kong X-Q, et al. Mutation p.S335X in GATA4 reduces its DNA binding affinity and enhances cell apoptosis associated with ventricular septal defect. Current Molecular Medicine. 2013;(6):993-999. Wu C, Yan H, Sun J, Yang F, Song C, Jiang F, Li Y, Dong J, Zheng G-Y, Tian X-L, et al. NEXN is a novel susceptibility gene for coronary artery disease in Han Chinese. PLoS ONE. 2013;(12). SCI被引用次数:16. Wang W-J, Han P, Zheng J, Hu F-Y, Zhu Y, Xie J-S, Guo J, Zhang Z, Dong J, Zheng G-Y, et al. Exon 47 skipping of fibrillin-1 leads preferentially to cardiovascular defects in patients with thoracic aortic aneurysms and dissections. Journal of Molecular Medicine [Internet]. 2013;(1):37-47. 访问链接 SCI被引用次数:19. Zhao L, Yang F, Xu K, Cao H, Zheng G-Y, Zhang Y, Li J, Cui H, Chen X, Zhu Z, et al. Common genetic variants of the β2-adrenergic receptor affect its translational efficiency and are associated with human longevity. Aging Cell [Internet]. 2012;(6):1094-1101. 访问链接 SCI被引用次数:20. Jiang F, Dong Y, Wu C, Yang X, Zhao L, Guo J, Li Y, Dong J, Zheng G-Y, Cao H, et al. Fine mapping of chromosome 3q22.3 identifies two haplotype blocks in ESYT3 associated with coronary artery disease in female Han Chinese. Atherosclerosis [Internet]. 2011;(2):397-403. 访问链接 SCI被引用次数:12. Zeng Y, Cheng L, Chen H, Cao H, Hauser ER, Liu Y, Xiao Z, Tan Q, Tian X-L, Vaupel JW. Effects of FOXO genotypes on longevity: A biodemographic analysis. Journals of Gerontology - Series A Biological Sciences and Medical Sciences [Internet]. 2010;(12):1285-1299. 访问链接 SCI被引用次数:50. Li Y, Wang W-J, Cao H, Lu J, Wu C, Hu F-Y, Guo J, Zhao L, Yang F, Zhang Y-X, et al. Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations. Human Molecular Genetics [Internet]. 2009;(24):4897-4904. 访问链接 SCI被引用次数:208. Feng Y, Liu D-Q, Wang Z, Liu Z, Cao H-Q, Wang L-Y, Shi N, Meng X-M. AOP-1 interacts with cardiac-specific protein kinase TNNI3K and down-regulates its kinase activity. Biochemistry (Moscow) [Internet]. 2007;(11):1199-1204. 访问链接 SCI被引用次数:15. Wang D, Liu Z, Li Q, Karpurapu M, Kundumani-Sridharan V, Cao H, Dronadula N, Rizvi F, Bajpai AK, Zhang C, et al. An essential role for gp130 in neointima formation following arterial injury. Circulation Research [Internet]. 2007;(6):807-816. 访问链接 SCI被引用次数:45. Feng Y, Cao HQ, Liu Z, Ding JF, Meng X-M. Identification of the dual specificity and the functional domains of the cardiac-specific protein kinase TNNI3K. General Physiology and Biophysics [Internet]. 2007;(2):104-109. 访问链接 SCI被引用次数:14. Zhang B, Cao H, Rao GN. Fibroblast growth factor-2 is a downstream mediator of phosphatidylinositol 3-kinase-Akt signaling in 14,15-epoxyeicosatrienoic acid-induced angiogenesis. Journal of Biological Chemistry [Internet]. 2006;(2):905-914. 访问链接 Cao H, Dronadula N, Rizvi F, Li Q, Srivastava K, Gerthoffer WT, Rao GN. Novel role for STAT-5B in the regulation of Hsp27-FGF-2 axis facilitating thrombin-induced vascular smooth muscle cell growth and motility. Circulation Research [Internet]. 2006;(7):913-922. 访问链接 SCI被引用次数:29. Cao H, Dronadula N, Rao GN. Thrombin induces expression of FGF-2 via activation of PI3K-Akt-Fra-1 signaling axis leading to DNA synthesis and motility in vascular smooth muscle cells. American Journal of Physiology - Cell Physiology [Internet]. 2006;(1):C172-C182. 访问链接 SCI被引用次数:40. Zhang B, Cao H, Rao GN. 15(S)-hydroxyeicosatetraenoic acid induces angiogenesis via activation of PI3K-Akt-mTOR-S6K1 signaling. Cancer Research [Internet]. 2005;(16):7283-7291. 访问链接 SCI被引用次数:48. Dronadula N, Liu Z, Wang C, Cao H, Rao GN. STAT-3-dependent cytosolic phospholipase A2 expression is required for thrombin-induced vascular smooth muscle cell motility. Journal of Biological Chemistry [Internet]. 2005;(4):3112-3120. 访问链接 SCI被引用次数:33.

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