个人简介

Dr. Courey, who is from Buffalo, New York, joined the UCLA faculty in 1990 and was promoted to full professor in 1999. He has served the Department of Chemistry and Biochemistry as Graduate Advisor (2003-2005), Vice Chair for Education (2001-2005), and Chair (2008-2012). He also serves on the Advisory Committee of the Molecular Biology Interdepartmental Program and is one of the founders of the Gene Regulation Interdepartmental Program. Dr. Courey has instructed a course at Cold Spring Harbor Laboratories in Protein Purification and Characterization every spring since 1996. His lab uses Drosophila melanogaster as a model organism to study transcriptional control mechanisms as well as the cell and developmental biology of SUMO, a ubiquitin-family protein. Dr. Courey has authored a textbook entitled Mechanisms in Transcriptional Regulation (Blackwell Publishing Company). He is an avid pianist and holds a Bachelor's degree in Piano Performance from the Oberlin College Conservatory of Music.

研究领域

Biochemistry/Systems Biology and Biological Regulation/Metabolism/Aging and Development/Chemical Biology/Gene Regulation

During embryogenesis, a cluster of apparently undifferentiated cells is transformed into an ordered array of differentiated tissues. Using Drosophila as a model system, my research group combines biochemical and genetic approaches to study the molecular basis of this amazing transformation. Essentially all the regulatory circuits we study are conserved throughout the animal kingdom. Therefore, our studies have important implications for human health and development.

近期论文

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Signaling Cascades, Gradients, and the Gene Networks in Dorsal/Ventral Patterning. Ratnaparkhi, G.S. and Courey, A.J. (2014) In Principles of Developmental Genetics Second Edition S. Moody (Ed.) Elsevier Press, pp. 216-240. SUMO as a Solubility Tag and In Vivo Cleavage of SUMO Fusion Proteins with Ulp1 In Protein Affinity Tags: Methods and Protocols Kuo, D., Nie, M., and Courey, A.J. (2014) R.J. Giannone and A. B. Dykstra (Eds.) Humana Press. Methods in Molecular Biology Series Vol. 1177, 71-80. Groucho: A Corepressor with Instructive Roles in Development Turki-Judeh, W. and Courey, A.J. (2012) Curr Top Dev Biol. ; 98:65-96. The Unconserved Groucho Central Region is Essential for Viability and Modulates Target Gene Specificity Turki-Judeh, W. and Courey, A.J. (2012) PLoS One ; 7(2):e30610. SUMOylation in drosophila development Smith,M., Turki-Judeh, W., Courey,A.J. (2012) Biomolecules ; 25:2(3):331-49. Small Ubiquitin-like Modifier (SUMO) Conjugation Impedes Transcriptional Silencing by the Polycomb Group Repressor Sex Comb on Midleg Smith, M., Mallin, D.R., Simon, J.A., Courey, A.J. (2011) J Biol Chem. Apr 1; 286(13):11391-400. A Sumo-groucho Q domain fusion protein: characterization and in vivo ulp1-mediated cleavage. Kuo, D., Nie, M., De Hoff, P., Chambers, M., Phillips, M., Hirsch, A.M., Courey A.J. (2011) Protein Expression and Purification ,Mar; 76(1):65-71. Groucho-mediated repression may result from a histone deacetylase-dependent increase in nucleosome density. Winkler, C.J., Ponce, A., Courey, A.J. (2010) PloS One ; 5(4): e10166. Genetic and proteomic evidence for roles of Drosophila SUMO in cell cycle control, Ras signaling, and early pattern formation. Nie, M., Xiek, Y., Loo, J.A., Courey, A.J. (2009) PloS One ;4(6): e5905. Dorsal interacting protein 3 potentiates activation by Drosophila Rel homology domain proteins. Ratnaparkhi, G.S., Duong, H.A., Courey, A.J. (2008) Developmental and Comparative Immunology ; 32(11): 1290-300.