郝海平 - 中国药科大学 - 天然药物活性组分与药效国家重点实验室

个人简介

郝海平，博士、中国药科大学教授，博士生导师。2006年于中国药科大学获博士学位，2012-2013年美国国家癌症研究所访问学者。现任中国药科大学药学院院长、2011计划建设办公室主任、“天然药物活性组分与药效”国家重点实验室副主任。为国家杰出青年科学基金获得者；首批中组部青年拔尖人才、江苏省特聘教授；2008年全国百篇优秀博士学位论文获得者、首批江苏省杰出青年科学基金获得者、江苏省“333”高层次人才培养工程中青年科技领军人才（第二层次）、第十一届江苏省十大青年科技之星、教育部新世纪人才、江苏省五四青年奖章获得者。构建了较完善、普适的体内外天然药物复杂成分定性、定量分析与体内过程研究的方法学体系，提出并建立了符合天然药物多成分多靶标作用特点的药代动力学研究理论与模式，并在揭示天然活性成分群代谢处置规律的基础上，提出了“反向药代动力学”、代谢处置导向的作用靶标与机理研究的学术思想；在胆汁酸、色氨酸等内源活性代谢调控研究中取得重要研究成果。近年来，主持承担国家重大新药创制专项、国家自然科学基金重点项目、重大研究计划等重大研究课题、国家杰出青年科学基金等各类项目17项。作为主要完成人之一，获国家科技进步二等奖2项（排名第三、第四）、2012年教育部科学技术进步一等奖（排名第二）。发表SCI论文100余篇，其中以第一和通讯作者在Nat Commun, Trends Pharmacol Sci,Anal Chem, Drug Metab Dispos等相关领域一流期刊发表SCI论文60余篇。

研究领域

1、内源活性分子代谢调控与药物靶标/确证研究：综合应用分子生物学、代谢组学与蛋白质组学技术，围绕肿瘤等代谢性疾病，探索药物作用新靶标，侧重于研究内源活性物质如胆汁酸、短链脂肪酸等代谢调控；在此基础上，研究临床具有确切疗效的中药/天然药物的作用靶标与作用机理，探索创新药物研发及药物治疗新理论方法。 2、中药/天然药物复杂成分代谢处置规律与机理研究：在创建复杂成分体内外分析技术平台的基础上，揭示中药/天然活性成分（群）在生物体内外的代谢处置规律与机理，阐明主要类群成分如苷类、黄酮类、生物碱类等活性成分群的构代关系；探索天然活性成分调控药物代谢酶/转运体的作用规律与机理，从而为基于天然药物/中药的创新药物研发和药物相互作用研究提供科学基础。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Zhou X, Cao L, Jiang C, Xie Y, Chen X, Krausz KW, Qi Y, Sun L, Shah YM, Gonzalez FJ, Wang G*, Hao H*. PPARα-UGT axis activation represses intestinal FXR-FGF15 feedback signalling and exacerbates experimental colitis. Nat Commun, 2014, 2014 Sep 3; 5:4573. doi: 10.1038/ncomms5573. 2. Hao H, Zheng X, Wang G*. Insights to drug discovery from natural medicines using reverse pharmacokinetics. Trends Pharmacol Sci, 2014, 35(4):168-177. 3. Zheng X, Kang A, Dai C, Liang Y, Xie T, Xie L, Peng Y, Wang G*, Hao H*.Quantitative analysis of neurochemical panel in rat brain and plasma by liquid chromatography-tandem mass spectrometry. Anal Chem. 2012 Nov 20;84(22):10044-51. 4. Gong, P.; Cui, N.; Wu, L.; Liang, Y.; Hao, K.; Xu, X.; Tang, W.; Wang, G*.; Hao, H*. Chemicalome and metabolome matching approach to elucidating biological metabolic networks of complex mixtures. Anal Chem, 2012; Mar 20;84(6):2995-3002 5. Cheng X, Liu F, Yan T, Zhou X, Wu L, Liao K, Wang G*, Hao H*. Metabolic Profile,Enzyme Kinetics, and Reaction Phenotyping of β-Lapachone Metabolism in Human Liver and Intestine in Vitro. Mol Pharm. 2012 9 (12), pp 3476–3485. 6. Long F, Yang H, Xu Y, Hao H*, Li P*. A strategy for the identification of combinatorial bioactive compounds contributing to the holistic effect of herbal medicines.Sci Rep. 2015 Jul 22;5:12361. doi: 10.1038/srep12361. 7. Wang H, Yan T, Xie Y, Zhao M, Che Y, Zhang J, Liu H, Cao L, Cheng X, Xie Y, Li F, Qi Q, Wang G, Hao H.Mechanism-based inhibitory and peroxisome proliferator-activated receptor α-dependent modulating effects of silybin on principal hepatic drug-metabolizing enzymes.Drug Metab Dispos. 2015 Apr;43(4):444-54. 8. Zhang J, Cao L, Wang H, Cheng X, Wang L, Zhu L, Yan T, Xie Y, Wu Y, Zhao M, Ma S, Wu M, Wang G, Hao H*.Ginsenosides Regulate PXR/NF-κB Signaling and Attenuate Dextran Sulfate Sodium-Induced Colitis.Drug Metab Dispos. 2015 Aug;43(8):1181-9 9. Zheng X, Zhang X, Wang G, Hao H*.Treat the brain and treat the periphery: toward a holistic approach to major depressive disorder.Drug Discov Today. 2015 May;20(5):562-8. 10. Zheng X, Zhang X, Kang A, Ran C, Wang G, Hao H.Thinking outside the brain for cognitive improvement: Is peripheral immunomodulation on the way?Neuropharmacology. 2015 Sep;96(Pt A):94-104. 11. Xie, Y.; Wang, G.; Wang, H.; Yao, X.; Jiang, S.; Kang, A.; Zhou, F.; Xie, T.; Hao, H*. Cytochrome P450 Dysregulations in Thioacetamide Induced Liver Cirrhosis in Rats and the Counteracting Effects of Hepatoprotective Agents. Drug Metab Dispos, 2012, Apr;40(4):796-802 12. Xie, T.; Liang, Y.; Hao, H*.; A, J.; Xie, L.; Gong, P.; Dai, C.; Liu, L.; Kang, A.; Zheng, X.; Wang, G*. Rapid identification of ophiopogonins and ophiopogonones in Ophiopogon japonicus extract with a practical technique of mass defect filtering based on high resolution mass spectrometry. J Chromatogr A, 2012, 1227, 234-44. 13. Wu L, Gong P, Wu Y, Liao K, Shen H, Qi Q, Liu H, Wang G*, Hao H*. An integral strategy toward the rapid identification of analogous nontarget compounds from complex mixtures. J Chromatogr A. 2013 Aug 16;1303:39-47. 14. Tang Z, Wu M, Li Y, Zheng X, Liu H, Cheng X, Xu L, Wang G*, Hao H*. Absolute quantification of NAD(P)H:quinone oxidoreductase 1 in human tumor cell lines and tissues by liquid chromatography-mass spectrometry/mass spectrometry using both isotopic and non-isotopic internal standards. Anal Chim Acta. 2013 Apr 15;772:59-67 15. Wu L, Wu Y, Shen H, Gong P, Cao L, Wang G*, Hao H*. Quantitative structure–ion intensity relationship strategy to the prediction of absolute levels without authentic standards. Anal Chim Acta. 2013 Sep 10;794:67-75. 16. Kang, A.; Hao, H*; Zheng, X.; Liang, Y.; Xie, Y.; Xie, T.; Dai, C.; Zhao, Q.; Wu, X.; Xie, L.; Wang, G*. Peripheral anti-inflammatory effects explain the ginsenosides paradox between poor brain distribution and anti-depression efficacy. J Neuroinflammation, 2011; 8:100. 17. Hao, H.; Zhang, L.; Jiang, S.; Sun, S.; Gong, P.; Xie, Y.; Zhou, X.; Wang, G*. Thioacetamide intoxication triggers transcriptional up-regulation but enzyme inactivation of UDP-glucuronosyltransferases. Drug Metab Dispos, 2011, 39 (10), 1815-22. 18. Hao H, Lai L, Zheng C, Wang Q, Yu G, Zhou X, Wu L, Gong P, Wang G.* Microsomal cytochrome P450 mediated metabolism of protopanaxatriol ginsenosides: metabolites profile, reaction phenotyping, and structure metabolism relationship, Drug Metab Dispos, 2010;38(10):1731-9. 19. Hao H, Cui N, Wang G*, Xiang B, Liang Y, Xu X, Zhang H, Yang J, Zheng C, Wu L, Gong P, Wang W. Global Detection and Identification of Non-target Components from Herbal Preparations by Liquid Chromatography Hybrid Ion-Trap Time-of-Flight Mass Spectrometry and a Novel Strategy. Anal Chem, 2008;80(21):8187-94. 20. Hao H, Wang G* and Sun J Enantioselective pharmacokinetics of ibuprofen and involved mechanisms.Drug Metab Rev.2005; 37(1):215-234.

学术兼职

兼任中国药学会应用药理专业委员会副秘书长、世界中医药联合会中药免疫专业委员会常务理事、世界中医药联合会中药分析委员理事、美国化学会（ACS）及国际药代动力学学会（ISSX）会员；Acta Pharmaceutica Sinica B编委，为 Mol Pharmaceut, Toxicol Sci, Curr Drug Metab, Drug Metab Dispos等药学相关领域一流SCI期刊的同行审稿专家。