肖易倍 - 中国药科大学

个人简介

肖易倍，博士。中国药科大学教授，博士生导师。同年作为海外高层次引进人才回到中国药科大学。主要利用生物化学，微生物学，药物设计学，和生物物理学等多学科结合研究思路与方法，研究细菌的获得性免疫防御系统（CRISPR-Cas）的分子作用机制，RNA病毒的转录复制机制以及抗病毒药物的开发。近三年已在Science, Nature和Cell杂志以第一作者发表论文四篇，共同作者发表两篇。学习与工作经历 04.2018 - 至今(教授): 中国药科大学, 药学院 02.2014 – 03.2018 (博士后): Department of Molecular Biology and Genetics, Cornell University, 美国 08.2008 - 01.2014 (博士): Institut für Biochemie, Universität zu Lübeck, 德国 09.2006 - 06.2008 (硕士): 武汉大学, 生命科学学院 09.2002 - 07.2006 (本科): 中国药科大学, 生命科学与技术人才培养基地

研究领域

1. 细菌获得性免疫系统CRISPR-Cas的作用机制。 2. 新型CRISPR-Cas系统的开发以及在基因编辑中的应用。 3. 新生RNA病毒关键药物靶点的研究以及抑制剂开发

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Xiao, Y., Luo, M., AE Dolan., Liao, M., Ke, A. (2018). Structure Basis for RNA-guided DNA degradation by Cascade and Cas3 in Type I-E CRISPR-Cas system. Science, (accepted). 2. Xiao, Y., Ng, S., Nam, KH., & Ke. A. (2017). How Type II CRISPR-Cas establishes immunity through Cas1-Cas2 mediated spacer integration. Nature, 550 (7674), 137. 3. Xiao, Y., Luo, M., Hayes, R. P., Kim, J., Ng, S., Ding, F., Liao, M., Ke, A. (2017). Structure basis for directional R-loop formation and substrate handover mechanisms in Type I CRISPR-Cas system. Cell, 170(1), 48-60. 4. MW Brown., KE Dillard., Y Xiao., AE Dolan., ET Hernandez., S Dahlhauser., …& Finkelstein, I. (2017). Assembly and translocation of a CRISPR-Cas primed acquisition complex. bioRxiv, 208058. 5. Jung, C., Hawkins, J., Jones Jr, S., Xiao, Y., … Ke, A., & Finkelstein, I. (2017). Massively parallel biophysical analysis of a CRISPR-Cas protein complex on repurposed next generation sequencing chips. Cell, 170(1), 35-47. 6. Xiao, Y. and Ke, A., (2016). PIWI Takes a Giant Step. Cell, 167(2), 310-312. 7. Hayes, R. P., Xiao, Y., Ding, F., Van Erp, P. B., Rajashankar, K., Bailey, S., ... & Ke, A. (2016). Structural basis for promiscuous PAM recognition in type I–E Cascade from E. coli. Nature, 530(7591), 499-503. 8. Qin, Z., Xiao, Y., Yang, X., Mesters, J. R., Yang, S., & Jiang, Z. (2015). A unique GCN5-related glucosamine N-acetyltransferase region exist in the fungal multi-domain glycoside hydrolase family 3 β-N-acetylglucosaminidase. Scientific reports, 5. 9. Huo, Y., Nam, K. H., Ding, F., Lee, H., Wu, L., Xiao, Y., ... & Ke, A. (2014). Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradation. Nature structural & molecular biology, 21(9), 771-777. 10. Xiao, Y., Ma, Q., Restle, T., Shang, W., Svergun, D. I., Ponnusamy, R., ... & Hilgenfeld, R. (2012). Nonstructural proteins 7 and 8 of feline coronavirus form a 2: 1 heterotrimer that exhibits primer-independent RNA polymerase activity. Journal of Virology, 86(8), 4444-4454."