个人简介
宋瑞,副教授,硕士生导师。2005年毕业于中国药科大学中药学专业,获学士学位,2010年获本校药物分析博士学位并留校任教。从事药物(中药)分析、药物(中药)代谢动力学研究,在相关领域国际著名学术期刊(JCA、RCM、JSS、BMC、Xenobiotica、Analytical Methods、Chromatographia等)上发表论文近30篇。作为负责人主持国家自然科学基金项目1项,省部级基金项目2项。作为主要成员参与完成国家自然科学基金(30672587、30873439)、江苏省基础研究计划(BK2006153)、国家中医药局中医药行业科研专项(200707008)等10余项国家及省部级科研项目。
2013-今,中国药科大学,药学院,药物分析教研室,副教授。
2010-2013年,中国药科大学,药学院,药物分析教研室,讲师。
2005-2010年,中国药科大学,药物分析博士。
2001-2005年,中国药科大学,中药学学士。
研究领域
以现代色谱、光谱及其联用技术为依托,开展(1)药物(中药)质量研究;(2)药物(中药)药代动力学研究;(3)中药体内过程(代谢、转运)研究
近期论文
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1、 Min Wang, Guangnan Hu, Yuan Tian, Zunjian Zhang*, Rui Song**(通讯作者), Influence of wine-processing on the pharmacokinetics of anthraquinone aglycones and glycosides from rhubarb in hyperlipidemic hamsters, RSC Advances, 2016, 6: 24871-24879. IF: 3.289
2、Pei Yu, Hongcong Qiu, Min Wang, Yuan Tian, Zunjian Zhang*, Rui Song*(通讯作者). In vitro metabolism study of saikosaponin d and its derivatives in rat liver microsomes. Xenobiotica, 2016, 6: 1-9. IF: 1.723
3、Wang Min, Fu Jinfeng, Guo Huimin, Tian Yuan, Xu Fengguo, Song Rui*(通讯作者), Zhang Zunjian*. Discrimination of crude and processed rhubarb products using a chemometric approach based on ultra fast liquid chromatography with ion trap/time-of-flight mass spectrometry. Journal of Separation Science, 2015, 38(3):395-401. IF:2.737
4、Jinfeng Fu, Rui Song*(通讯作者), Min Wang, Huimin Guo, Zunjian Zhang*. Profiling of Components of Rhizoma et Radix Polygoni Cuspidati by High Performance Liquid Chromatography with UV Diode-array Detector and Ion trap/time-of-flight Mass Spectrometric Detection. Pharmacognosy Magazine. 2015, 11(43): 486-501 IF:1.256
5、Min Wang,Yuan Tian, Mengying Lv, Fengguo Xu, Zunjian Zhang*, Rui Song**(通讯作者), Targeted quantitative analysis of anthraquinone derivatives by high-performance liquid chromatography coupled to tandem mass spectrometry to discriminate crude and processed rhubarb samples, Analytical Methods, 2015, 7: 5375-5380. IF:1.821
6、Wang Min, Fu Jinfeng, Lv Mengying, Tian Yuan, Xu Fengguo, Song Rui*(通讯作者), Zhang Zunjian*. Effect of wine processing and acute blood stasis on the serum pharmacochemistry of rhubarb: A possible explanation for processing mechanism. Journal of Separation Science. 2014 , 37(18):2499-503. IF:2.737
7、Guoqiang Liu, Yuan Tian, Geng Li, Lei Xu, Rui Song, Zunjian Zhang*. Metabolism of saikosaponin a in rats: diverse oxidations on the aglycone moiety in liver and intestine in addition to hydrolysis of glycosidic bonds [J]. Drug Metabolism Disposition, 2013, 41(3): 622-633. IF: 3.210
8、Lei Xu, Rui Song, Jixin Tian, Yuan Tian, Guoqiang Liu, Zunjian Zhang*. Analysis of saikosaponins in rat plasma by anionic adducts-based liquid chromatography tandem mass spectrometry method [J]. Biomedical Chromatography, 2012, 26(7): 808-815. IF: 1.945
9、Rui Song, Ying Cheng, Yuan Tian, Zunjian Zhang*. A validated solid−phase extraction HPLC method for the simultaneous determination of gallic acid, catechin and epicatechin in rhubarb decoction. Chinese Journal of Natural Medicines 2012, 10(4): 0275-0278. IF: 1.382
10、Rui Song, Lei Xu, Fengguo Xu, Hanjuan Dong, Yuan Tian, Zunjian Zhang*. Metabolic analysis of rhubarb extract by rat intestinal bacteria using liquid chromatograpy-tandem mass spectrometry. Biomedical Chromatography, 2011, 25(3): 417-426. IF: 1.966
11、Rui Song, Lei Xu, Fengguo Xu, Zhe Li, Hanjuan Dong, Yuan Tian, Zunjian Zhang*. In vivo metabolism study of rhubarb decoction in rat using high-performance liquid chromatography with UV photodiode-array and mass spectrometric detection: a strategy for systematic analysis of metabolites from traditional Chinese medicines in biological samples. Journal of Chromatography A , 2010, 1217 (45): 7144-7152. IF: 4.194
12、Rui Song, Lei Xu, Zunjian Zhang*, Yuan Tian, Fengguo Xu, Hanjuan Dong. Determination of gallic acid in rat plasma by LC-MS/MS. Chromatographia, 2010, Jun, 71(11/12): 1107-1111. IF: 1.075
13、Rui Song, Hui Lin, Zunjian Zhang*, Zhe Li, Lei Xu, Haijuan Dong, Yuan Tian. Profiling the metabolic difference of anthraquinone derivatives using liquid chromatography/ tandem mass spectrometry with data-dependent acquisition. Rapid Communications in Mass Spectrometry, 2009, 23(4):537-547. IF: 2.695
14、Rui Song, Fengguo Xu , Zunjian Zhang *, Ying Liu , Haijuan Dong, Yuan Tian. Structural elucidation of in vitro metabolites of Emodin by liquid chromatography–tandem mass spectrometry. Biomedical Chromatography, 2008, 22(11):1230-1236. IF: 1.592.