宋瑞 - 中国药科大学

个人简介

宋瑞，副教授，硕士生导师。2005年毕业于中国药科大学中药学专业，获学士学位，2010年获本校药物分析博士学位并留校任教。从事药物（中药）分析、药物（中药）代谢动力学研究，在相关领域国际著名学术期刊（JCA、RCM、JSS、BMC、Xenobiotica、Analytical Methods、Chromatographia等）上发表论文近30篇。作为负责人主持国家自然科学基金项目1项，省部级基金项目2项。作为主要成员参与完成国家自然科学基金（30672587、30873439）、江苏省基础研究计划（BK2006153）、国家中医药局中医药行业科研专项（200707008）等10余项国家及省部级科研项目。 2013-今，中国药科大学，药学院，药物分析教研室，副教授。 2010-2013年，中国药科大学，药学院，药物分析教研室，讲师。 2005-2010年，中国药科大学，药物分析博士。 2001-2005年，中国药科大学，中药学学士。

研究领域

以现代色谱、光谱及其联用技术为依托，开展（1）药物（中药）质量研究；（2）药物（中药）药代动力学研究；（3）中药体内过程（代谢、转运）研究

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1、 Min Wang, Guangnan Hu, Yuan Tian, Zunjian Zhang*, Rui Song**（通讯作者）, Influence of wine-processing on the pharmacokinetics of anthraquinone aglycones and glycosides from rhubarb in hyperlipidemic hamsters, RSC Advances, 2016, 6: 24871-24879. IF: 3.289 2、Pei Yu, Hongcong Qiu, Min Wang, Yuan Tian, Zunjian Zhang*, Rui Song*（通讯作者）. In vitro metabolism study of saikosaponin d and its derivatives in rat liver microsomes. Xenobiotica, 2016, 6: 1-9. IF: 1.723 3、Wang Min, Fu Jinfeng, Guo Huimin, Tian Yuan, Xu Fengguo, Song Rui*（通讯作者）, Zhang Zunjian*. Discrimination of crude and processed rhubarb products using a chemometric approach based on ultra fast liquid chromatography with ion trap/time-of-flight mass spectrometry. Journal of Separation Science, 2015, 38(3):395-401. IF:2.737 4、Jinfeng Fu, Rui Song*（通讯作者）, Min Wang, Huimin Guo, Zunjian Zhang*. Profiling of Components of Rhizoma et Radix Polygoni Cuspidati by High Performance Liquid Chromatography with UV Diode-array Detector and Ion trap/time-of-flight Mass Spectrometric Detection. Pharmacognosy Magazine. 2015, 11(43): 486-501 IF:1.256 5、Min Wang,Yuan Tian, Mengying Lv, Fengguo Xu, Zunjian Zhang*, Rui Song**（通讯作者）, Targeted quantitative analysis of anthraquinone derivatives by high-performance liquid chromatography coupled to tandem mass spectrometry to discriminate crude and processed rhubarb samples, Analytical Methods, 2015, 7: 5375-5380. IF:1.821 6、Wang Min, Fu Jinfeng, Lv Mengying, Tian Yuan, Xu Fengguo, Song Rui*（通讯作者）, Zhang Zunjian*. Effect of wine processing and acute blood stasis on the serum pharmacochemistry of rhubarb: A possible explanation for processing mechanism. Journal of Separation Science. 2014 , 37(18):2499-503. IF:2.737 7、Guoqiang Liu, Yuan Tian, Geng Li, Lei Xu, Rui Song, Zunjian Zhang*. Metabolism of saikosaponin a in rats: diverse oxidations on the aglycone moiety in liver and intestine in addition to hydrolysis of glycosidic bonds [J]. Drug Metabolism Disposition, 2013, 41(3): 622-633. IF: 3.210 8、Lei Xu, Rui Song, Jixin Tian, Yuan Tian, Guoqiang Liu, Zunjian Zhang*. Analysis of saikosaponins in rat plasma by anionic adducts-based liquid chromatography tandem mass spectrometry method [J]. Biomedical Chromatography, 2012, 26(7): 808-815. IF: 1.945 9、Rui Song, Ying Cheng, Yuan Tian, Zunjian Zhang*. A validated solid−phase extraction HPLC method for the simultaneous determination of gallic acid, catechin and epicatechin in rhubarb decoction. Chinese Journal of Natural Medicines 2012, 10(4): 0275-0278. IF: 1.382 10、Rui Song, Lei Xu, Fengguo Xu, Hanjuan Dong, Yuan Tian, Zunjian Zhang*. Metabolic analysis of rhubarb extract by rat intestinal bacteria using liquid chromatograpy-tandem mass spectrometry. Biomedical Chromatography, 2011, 25(3): 417-426. IF: 1.966 11、Rui Song, Lei Xu, Fengguo Xu, Zhe Li, Hanjuan Dong, Yuan Tian, Zunjian Zhang*. In vivo metabolism study of rhubarb decoction in rat using high-performance liquid chromatography with UV photodiode-array and mass spectrometric detection: a strategy for systematic analysis of metabolites from traditional Chinese medicines in biological samples. Journal of Chromatography A , 2010, 1217 (45): 7144-7152. IF: 4.194 12、Rui Song, Lei Xu, Zunjian Zhang*, Yuan Tian, Fengguo Xu, Hanjuan Dong. Determination of gallic acid in rat plasma by LC-MS/MS. Chromatographia, 2010, Jun, 71(11/12): 1107-1111. IF: 1.075 13、Rui Song, Hui Lin, Zunjian Zhang*, Zhe Li, Lei Xu, Haijuan Dong, Yuan Tian. Profiling the metabolic difference of anthraquinone derivatives using liquid chromatography/ tandem mass spectrometry with data-dependent acquisition. Rapid Communications in Mass Spectrometry, 2009, 23(4):537-547. IF: 2.695 14、Rui Song, Fengguo Xu , Zunjian Zhang *, Ying Liu , Haijuan Dong, Yuan Tian. Structural elucidation of in vitro metabolites of Emodin by liquid chromatography–tandem mass spectrometry. Biomedical Chromatography, 2008, 22(11):1230-1236. IF: 1.592.