张文丽 - 中国药科大学

个人简介

张文丽、副教授、硕士生导师，江苏省药物研究与开发协会会员，International Journal of Pharmaceutics，Materials Science and Engineering C 审稿人。2011年毕业于中国药科大学药剂学专业，留校任教至今，2012年12月至2014年3月赴新西兰奥克兰大学药学院进修博士后。担任生物药剂学实验课程负责人，主讲生物药剂学理论及实验课（双语），制剂工程学，药剂学实验课（双语），药学英语，研究生生物药学等课程。主持“国家自然科学基金”（1项，81503005），“国家教育部博士点基金”（1项，20120096120005），“江苏省自然科学基金”（1项，BK20140669），中央高校基本科研业务费专项基金（3项），作为骨干成员参与国家国际科技合作专项项目1项，国家自然科学基金项目4项，“国家重大新药创制平台”子项目。近年来在Journal of Controlled Release, Biomaterials, Pharmerceutical Research, International Journal of Pharmaceutics 等国外药剂学杂志发表SCI论文近30篇，其中以一作发表的论文累积影响因子达40分以上，并发表国内外会议论文5篇，授权发明专利1项。曾获2015年南京市第十一届自然科学优秀学术论文奖三等奖；2014年-AAPS国际学术报告会海报三等奖。主要从事抗癌药物，心血管药物的靶向传输和新型智能释药系统的研究。

研究领域

主要从事抗癌药物，心血管药物的靶向传输和新型智能释药系统的研究

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1、Wenli Zhang#, Hongliang He*, Jianping Liu, Ji Wang, Suyang Zhang, Shuangshuang Zhang, Zimei Wu. Pharmacokinetics and atherosclerotic lesions targeting effects of tanshinone IIA discoidal and spherical biomimetic high density lipoproteins. Biomaterials. 2013, 34(1): 306-19. (SCI, IF=8.557) 2、Wenli Zhang, Guangji Wang, Esther See, John P. Shaw, Bruce C. Baguley, Jianping Liu, Satya Amirapu, Zimei Wu. Post-insertion of poloxamer 188 strengthened liposomal membrane and reduced drug irritancy and in vivo precipitation, superior to PEGylation. J. Control. Release. 2015, 203: 161-169. (SCI, IF=7.705) 3、Wenli Zhang, Falconer JR, Bruce C. Baguley, John P. Shaw, Kanamala M, Hongtao Xu, Guangji Wang, Jianping Liu, Satya Amirapu, Zimei Wu. Improving drug retention in liposomes by aging with the aid of glucose. Int. J. Pharm. 2016, 505(1-2): 194-203. (SCI, IF=3.9) 4、Zhang W, Wang G, Falconer JR, Baguley BC, Shaw JP, Liu J, Xu H, See E, SunJ, Aa J, Wu Z. Strategies to Maximize Liposomal Drug Loading for a Poorly Water-soluble Anticancer Drug. Pharm. Res. 2015, 32(4): 1451-1461. (SCI, IF=3.42) 5、 Wenli Zhang, Yan Xiao, Jianping Liu, Zimei Wu, Xiao Gu, Yiming Xu, Hui Lu. Structure and remodeling behavior of drug-loaded high density lipoproteins and their atherosclerotic plaque targeting mechanism in foam cell model. Int. J. Pharm. 2011, 419: 314-321. (SCI, IF=3.9) 6、Zhang WL, Gu X, Hui Bai, Ruhui Yang, Chendong Dong, Jianping Liu. Nanostructured lipid carriers constituted from high-densiy lipoprotein components for delivery of a lipophilic cardiovascular drug. Int. J. Pharm. 2010, 391: 313-321. (SCI, IF=3.65) 7、Wenli Zhang, Ji Wang, Junting Jia, Liang Chen, Zimei Wu, Jianping Liu. A Simple Method to Extract Whole Apolipoproteins for the Preparation of Discoidal Recombined High Density Lipoproteins as Bionic Nanocarriers for Drug Delivery. J. Pharm. Pharm. Sci. 2015, 18(2): 184-198. (SCI, IF=1.856) 8、Wenli Zhang, Jianping Liu, Suchun Li, Mengyuan Chen, Huan Liu. Preparation and evaluation of stealth Tashinone IIA-loaded solid lipid nanoparticles: Influence of Poloxamer 188 coating on phagocytic uptake. J. Microencapsul. 2008, 25(3): 203-209. (SCI, IF=1.585) 9、Zhang W, Li J, Liu J, Wu Z, Xu Y, Wang J. Tanshinone IIA-loaded reconstituted high density lipoproteins: Atherosclerotic plaque targeting mechanism in foam cell model and pharmacokinetics in rabbits. Pharmazie. 2012, 67(4): 324-330. (SCI, IF=1.052) 10、Zhang WL, Jianping Liu, XX Liu, ZQ Chen. Stealth tanshinone IIA-loaded solid lipid nanoparticles: effects of poloxamer 188 coating on in vitro phagocytosis and in vivo pharmacokinetics in rats. Acta Pharmaceutica Sinica. 2009, 44(12): 1421-1428. 11、See E#, Zhang W#, Liu J, Svirskis D, Baguley BC, Shaw JP, Wang G, Wu Z. Physicochemical characterization of asulacrine towards the development of an anticancer liposomal formulation via active drug loading: Stability, solubility, lipophilicity and ionization. Int. J. Pharm.2014, 473 (1–2): 528–535. (SCI, IF=3.9) 12、Hongxiang Yan, Jin Li, Zhenghua Li, Wenli Zhang*, Jianping Liu*. Tanshinone IIA-loaded pellets developed for angina chronotherapy: Deconvolution-based formulation design and optimization, pharmacokinetic and pharmacodynamic evaluation. Eur. J. Pharm. Sci. 2015, 76:156-164. (SCI, IF=3.35) 13、Hongliang He, Mengyuan Zhang, Lisha Liu, Shuangshuang Zhang, Jianping Liu*, Wenli Zhang*. Suppression of Remodeling Behaviors with Arachidonic Acid Modification for Enhanced in vivo Antiatherogenic Efficacies of Lovastatin-loaded Discoidal Recombinant High Density Lipoprotein. Pharm. Res. 2015,10: 3415-3431. (SCI, IF=3.42)