孙慧涌 - 中国药科大学

个人简介

孙慧涌，博士，副研究员，硕士研究生导师。2015年毕业于苏州大学功能纳米与软物质研究院（FUNSOM），获博士学位，随后加入浙江大学药学院从事博士后研究，主要研究方向为计算机辅助药物设计。迄今发表SCI论文60余篇（包括第一或通讯作者论文20篇）。5篇第一作者论文入选ESI或扩展ESI高引用论文，论文引用总数超过2500次。相关的第一或通讯作者论文发表于Chemical Reviews（1篇）、Journal of Chemical Theory and Computation（1篇）、PLoS Computational Biology（1篇）、British Journal of Pharmacology（1篇）、Drug Discovery Today（2篇）、Journal of Chemical Information and Modeling（5篇）、Physical Chemistry Chemical Physics（3篇）、Journal of Physical Chemistry B（1篇）、Scientific Reports（2篇）、Structural Dynamics（1篇）、Biochemical and Biophysical Research Communications（1篇）、Molecular Biosystems（1篇）等本行业重要期刊中。担任Journal of Chemical Information and Modeling（IF=3.966）青年编委及Frontiers in Molecular Biosciences（IF=3.565）特刊编委。

研究领域

（1）基于分子模拟技术的药物发现及机制分析（2）基于人工智能技术的药物设计

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

E.C. Wang#, H.Y. Sun# (co-first author), J.M. Wang, Z. Wang, H. Liu, J.Z.H. Zhang*, T.J. Hou*, End-Point binding free energy calculation with MM/PBSA and MM/GBSA: strategies and applications in drug design, Chemical Reviews, 2019, 119, 16, 9478-9508. (cover story) L. Xu#, X.Q. Ding#, T.H. Wang#, S.Z. Mou, H.Y. Sun* (corresponding author), T.J. Hou*, Voltage-Gated Sodium Channels: Structures, Functions and Molecular Modeling, Drug Discovery Today, 2019, 24, 1389-1397. H.Y. Sun, L.L. Duan, F. Chen, H. Liu, Z. Wang, P.C. Pan, D. Li, F. Zhu, J.Z.H. Zhang, T.J. Hou*, Assessing the performance of MM/PBSA and MM/GBSA methods. 7. Entropy effects on the performance of end-point binding free energy calculation approaches, Physical Chemistry Chemical Physics, 2018, 20, 14450-14460. H.Y. Sun, Y.Y. Li, M.Y. Shen, D. Li, Y. Kang, and T.J. Hou*, Characterizing Drug-Target Residence Time with Metadynamics: How to Achieve Dissociation Rate Efficiently without Losing Accuracy against Time-Consuming Approaches, Journal of Chemical Information and Modeling, 2017, 57, 1895-1906. H.Y. Sun, P.C. Chen, D. Li, Y.Y. Li, and T.J. Hou*, Directly Binding Rather than Induced-Fit Dominated Binding Affinity Difference in (S)- and (R)-Crizotinib Bound MTH1, Journal of Chemical Theory and Computation, 2016, 12, 851-860. H.Y. Sun,T.J. Hou*, and H.Y. Zhang*, Finding chemical drugs for genetic diseases, Drug Discovery Today, 2014, 19, 1836-1840. (feature article) H.Y. Sun, Y.Y. Li, S. Tian, J.M. Wang, and T.J. Hou*, P-loop Conformation Governed Crizotinib Resistance in G2032R-Mutated ROS1 Tyrosine Kinase: Clues from Free Energy Landscape, PLoS Computational Biology, 2014, 10, e1003729. (extended ESI high-cited paper) H.Y. Sun, Y.Y. Li, S. Tian, L. Xu, and T.J. Hou*, Assessing the Performance of MM/PBSA and MM/GBSA Methods. 4. Accuracies of MM/PBSA and MM/GBSA Methodologies Evaluated by Various Simulation Protocols using PDBbind Data Set, Physical Chemistry Chemical Physics, 2014, 16, 16719-16729.(extended ESI high-cited paper) H.Y. Sun, Y.Y. Li, M.Y. Shen, S. Tian, L. Xu, P.C. Pan, Y. Guan, and T.J. Hou*, Assessing the Performance of MM/PBSA and MM/GBSA Methods. 5. Improved Docking Performance by Using High Solute Dielectric Constant MM/GBSA and MM/PBSA Rescoring, Physical Chemistry Chemical Physics, 2014, 16, 22035-22045. (extended ESI high-cited paper) H.Y. Sun, Y.Y. Li*, D. Li, and T.J. Hou*, Insight into Crizotinib Resistance Mechanisms Caused by Three Mutations in ALK Tyrosine Kinase using Free Energy Calculation Approaches, Journal of Chemical Information and Modeling, 2013, 53, 2376-2389.