徐晓莉 - 中国药科大学

个人简介

徐晓莉，博士，副教授，药物化学专业硕士生导师。2009年7月本科毕业于中国药科大学国家生命科学与技术人才培养基地班，后继续攻读中国药科大学药学院药物化学专业硕博连读研究生，2014年6月获理学博士学位，2014年7月-2017年6月在中国药科大学中药学院从事师资博士后研究，2017年7月获得副高级职称并留校任教于药学院药物化学系。

研究领域

药物化学，通过运用计算机辅助药物设计、化学生物学、药物化学等多学科交叉手段，开展基于热休克伴侣系统等靶点的抗肿瘤创新药物研发工作

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

[1]. Fen Jiang, Hui-Jie Wang, Yu-Hui Jin, Qiong Zhang, Zhi-Hui Wang, Jian-Min Jia,Fang Liu, Lei Wang,Qi-Chao Bao, Dong-Dong Li, Qi-Dong You,*and Xiao-Li Xu*.Novel Tetrahydropyrido[4,3-d]pyrimidines as Potent Inhibitors of Chaperone Heat Shock Protein 90. J. Med. Chem. 2016, 59, 10498-10519. [2]. Xiao-li Xu, Ying-rui Yang, Xiao-fei Mo, Jin-lian Wei, Xiao-jin Zhang, You, Q. D* Design, synthesis, and evaluation of benzofuran derivatives as novel anti-pancreatic carcinoma agents via interfering the hypoxia environment by targeting HIF-1a pathway. Eur. J. Med. Chem., 2017, 137, 45-62. [3].Wang, L,Li, L.,Zhou, Z. H.,Jiang, Z. Y.,You, Q. D*., Xiao-Li Xu*.Structure-based virtual screening and optimization of modulators targeting Hsp90-Cdc37 interaction. Eur. J. Med. Chem., 2017, 136, 63-73. [4]. Fen Jiang, An-ping Guo, Jia-cheng Xu, Hui-Jie Wang, Xiao-fei Mo, You, Q.-D.*,Xiao-Li Xu*. Identification and optimization of novel 6-acylamino-2-aminoquinolines as potent Hsp90 C-terminal inhibitors. Eur. J. Med. Chem., 2017, 141, 1-14. [5].Xiao-Li Xu1, Yue Wu, Mingyang Hu, Huang Chen.You, Qidong You*, Xiaojin Zhang*.Structure-activity relationship of Garcinia xanthones analogues: Potent Hsp90 inhibitors with cytotoxicity and antiangiogenesis activity. Bioorg. Med. Chem. 2016, 24, 4626-35. [6] Fen Jiang, Hui-Jie Wang, Qi-Chao Bao, Lei Wang, Yu-Hui Jin, Qiong Zhang, Di Jiang, Qi-Dong You*,Xiao-Li Xu*.Optimization and biological evaluation of celastrol derivatives as Hsp90-Cdc37 interaction disruptors with improved druglike properties. Bioorg. Med. Chem. 2016, 24, 5431-5439.