姚和权 - 中国药科大学

个人简介

姚和权，1977年出生，中国药科大学药学院药物化学系教授、天然药物活性组分与药效国家重点实验室教授，博士生导师，天然活性分子发现和优化校级重点实验室主任。2012年8月起担任中国药科大学科学技术处副处长，兼任江苏省青联委员，江苏省青年科学家联合会执委。分别于1998年和2001年在中国药科大学获学士学位和硕士学位，2004年在中国科学院上海有机化学研究所获有机化学专业博士学位。2004年9月至2007年11月在美国斯坦福大学医学院从事博士后研究工作，2008年初回国任教授。入选2009年度教育部新世纪优秀人才支持计划， 2010年获霍英东基金（基础性研究课题）资助，作为骨干成员入选2011年度教育部“长江学者和创新团队发展计划”创新团队。已主持“重大新药创制”国家科技重大专项、国家自然科学基金面上项目、青年项目等国家省部级研究项目和人才项目10余项。迄今已在Angew. Chem. Int. Ed.、PNAS、Chem. Commun.、Org. Lett.、Chem Eur-J.、Adv. Synth. Catal.、J. Org. Chem.等国际知名刊物上发表SCI论文80余篇，论文总被引次数超过1200次。目前课题组主要致力于活性天然产物的全合成/结构修饰/生物学评价研究以及活性分子合成导向的催化有机反应方法学研究。课题组在读博士生4名，硕士生12名。热忱欢迎有志于药物化学和有机化学研究的优秀学子加入。学习与工作经历 2008年01月-：中国药科大学，药物化学，教授 2004年09月-2007年11月美国斯坦福大学, 化学生物学，博士后 2001年08月-2004年07月中科院上海有机所，有机化学，博士 1998年09月-2001年06月中国药科大学，药物化学，硕士 1994年09月-1998年06月中国药科大学，化学制药，学士

研究领域

1. 活性天然产物的全合成、结构修饰和生物学评价研究：针对具有强生物活性的天然产物如生物碱类、环状萜类，开展活性天然产物的全合成、结构修饰与生物学评价以及基于活性天然产物模板的创新药物研究。 2. 活性分子合成导向的催化有机反应方法学研究：以有机化学的基本理论为基础，以金属催化和有机催化在复杂活性天然分子和活性先导化合物以及现有药物的合成中的潜在应用为目标，开展导向活性分子合成的惰性化学键活化，不对称金属催化以及有机催化反应方法学研究，特别注重催化反应在药物分子合成中的应用。

近期论文

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1.Shang GaoФ, Zijun WuФ, Xinxin Fang, Aijun Lin*, Hequan Yao*. Palladium-catalyzed Dearomative Allylic Alkylation of Indoles with Alkynes to Synthesize Indolenines with C3-Quarternary Centers. Org. Lett. 2016, accepted. (IF 6.732) (Фequal contribution) 2.Zhenbo Yuan, Weiwei Wei, Aijun Lin*, Hequan Yao*. Bifunctional Organo/Metal Cooperatively Catalyzed [3+2] Annulation of Para-Quinone Methides with Vinylcyclopropanes: Approach to Spiro[4.5]deca-6,9-diene-8-ones. Org. Lett. 2016, 18, 3370-3373. (IF 6.732) 3.Xuanyi Li, Xiuyan Xu, Weiwei Wei, Aijun Lin*, Hequan Yao*. Organocatalyzed Asymmetric 1,6-conjugate Addition of para-Quinone Methides with Dicyanoolefins. Org. Lett. 2016, 18, 428-431. (IF 6.732) 4.Hui Jiang, Shang Gao, Jinyi Xu, Xiaoming Wu, Aijun Lin*, Hequan Yao*. Multiple Roles of Pyrimidyl Group in the Rh-Catalyzed Regioselective Synthesis and Functionalization of Indole-3-Carboxylic Acid Esters. Adv. Synth. Catal.2016, 358, 188–194. (IF 6.453) 5.Youzhi Wu, Peng Sun, Kaifan Zhang, Tie Yang, Hequan Yao*, Aijun Lin*. Rh(III)-catalyzed Redox-neutral Annulation of Primary Arylamides with Diazo Compounds: Approach to Isoquinolinones. J. Org. Chem.2016, 81, 2166-2173. (IF 4.785) 6.Peng Sun, Youzhi Wu, Yue Huang, Xiaoming Wu, Jinyi Xu, Hequan Yao*, Aijun Lin*. Rh(III)-Catalyzed Redox-Neutral Annulation of Azo and Diazo Compounds: One-step Access to Cinnolines. Org. Chem. Front., 2016, 3, 91-95. (IF 4.693) 7.Kuo Gai, Xinxin Fang, Xuanyi Li, Jinyi Xu, Xiaoming Wu, Aijun Lin*, Hequan Yao*. Synthesis of Spiro[2.5]octa-4, 7-dien-6-one via 1, 6-Conjugate Addition Induced Dearomatization of para-Quinone Methides with Bromomalonates. Chem. Commun.2015, 51, 15831-15834. (IF 6.834) 8.Youla SuФ, Shang GaoФ, Yue Huang, Aijun Lin*, Hequan Yao*. Solvent- controlled C2/C5-regiodivergent alkenylation of pyrroles. Chem. Eur. J.2015, 21, 15820-15825. (Фequal contribution) (IF 5.731) 9.Xuanyi Li, Kuo Gai, Zhenbo Yuan, Jie Wu, Aijun Lin*, Hequan Yao*. Organocatalyzed formal [4+2] cycloaddition of in situ generated azoalkenes with aryl acetic acids: an efficient approach to the synthesis of 4, 5-dihydropyridazin-3(2H)-ones. Adv. Synth. Catal.2015, 357, 3479–3484. (IF 5.663) 10.Peng SunФ, Youzhi WuФ, Jinyi Xu, Xiaoming Wu, Aijun Lin*, Hequan Yao*. Synthesis of Heterocycle-fused-Pyridine N-Oxides from Oximes and Diazo Compounds via Rh(III)-Catalyzed C-H Activation and Annulation. Adv. Synth. Catal. 2015, 357(11), 2469-2473. (Фequal contribution) (IF 5.663) 11.Zhenbo Yuan, Xinxin Fang, Xuanyi Li, Jie Wu, Hequan Yao*，Aijun Lin*. 1, 6-Conjugated Addition Mediated Dearomatization: Approach to Spiro[2.5]octa-4,7-dien-6-ones. J. Org. Chem.2015, 80 (21), 11123–11130. (IF 4.721) 12.Hengyuan Zhang, Yiwei Wang, Peiqing Zhu, Jie Liu, Shengtao Xu, Hequan Yao*, Jieyun Jiang, Wencai Ye, Xiaoming Wu, Jinyi Xu∗. Design, synthesis and antitumor activity of triterpenoid pyrazine derivatives from 23-hydroxybetulinic acid. Eur. J. Med. Chem.2015, 88, 235-244. (IF 3.447) 13.Youla Su, Haipin Zhou, Jiaxuan Chen, Jinyi Xu, Xiaoming Wu, Aijun Lin*, Hequan Yao*. Solvent-controlled Switchable C-H Alkenylation of 4-Aryl 1H-pyrrole 3-carboxylates: Application to the Total Synthesis of (±)-Rhazinilam. Org. Lett. 2014, 16, 4884-4887. (IF 6.324) 14.Hengyuan Zhang, Peiqing Zhu, Jie Liu, Xue Yang, Shengtao Xu, Hequan Yao*, Jieyun Jiang, Wencai Ye, Xiaoming Wu, Jinyi Xu*. Synthesis and antitumor activity of novel 3-oxo-23-hydroxybetulinic acid derivatives. Eur. J. Med. Chem.2014, 87, 159-167. (IF 3.432) 15.Ziyuan Li, Ling Ma, Jinyi Xu, Lingyi Kong, Xiaoming Wu, Hequan Yao*. Pd(II)-Catalyzed Direct C5-Arylation of Azole-4-carboxylates through Double C-H Bond Cleavage. Chem. Commun. 2012, 48(31), 3763-3765. (IF 6.378) 16.Lei Zhao, Ziyuan Li, Lin Chang, Jinyi Xu, Hequan Yao*, Xiaoming Wu*. Efficient Construction of Fused Indolines with 2-Quaternary Center via Intramolecular Heck Reaction with Low Catalyst Loading. Org. Lett.2012, 14(8), 2066-2069. (IF 6.142) 17.Ying Kong, Hequan YaoФ, Hongjun RenФ, Selvakumar SubbianФ, Suat Cirillo, James Sacchettini, Jianghong Rao*, Jeffrey Cirillo*. Imaging tuberculosis with endogenous β-Lactamase reporter enzyme fluorescence in live mice. Proc Nat. Acad. Soc. 2010, 107(27), 12239-12244. (Фequal contribution). (IF 9.771) 18.Hequan Yao, Yuan Gao, Peng Liu, Bingfeng Sun, Xingxiang Xu*. Asymmetric synthesis of the diene unit of Methyl sartortuoate via a temperature sensitive intramolecular Horner-Wadsworth-Emmons (HWE) reaction. Synlett2007, (4), 571-574. (IF 2.763) 19.Hequan YaoФ, Min-Kyung SoФ, Jianghong Rao*. A bioluminogenic substrate for in vivo imaging of β-lactamase activity. Angew. Chem. Int. Ed.2007, 46(37), 7031-7034. (Фequal contribution). (IF 10.031) 20.Hequan Yao, Yan Zhang, Fei Xiao, Zuyong Xia, Jianghong Rao*. A QD-BRET-based highly sensitive detection of protease. Angew. Chem. Int. Ed. 2007, 46(23), 4346-4349. (IF 10.031)