向华 - 中国药科大学

个人简介

向华，博士，药学院药物化学教授，博士生导师。主要从事抗肿瘤和抗代谢性疾病药物研究，重点开展与性激素代谢紊乱有关的肿瘤(乳腺癌、子宫内膜癌、卵巢癌、前列腺癌等)和老年病(更年期骨质疏松、良性前列腺增生、血脂异常、II型糖尿病等)治疗药物的研究与开发;此外，还从事甾体新药开发及老品种合成工艺改进、甾体新资源的开发和利用。学习和工作经历 1985.7 四川大学化学系有机化学专业学士; 1988.7 四川大学化学系有机分析专业硕士; 1988.7-2000.9 湖南省中医药研究院新药研发省级重点实验室、湖南正清制药集团新药研发中心从事药物化学和新药研发工作; 2003.12 中国药科大学药学院药物化学专业博士; 2002.8-2003.9 Institute of Organic Chemistry, University of Tuebingen, Germany (德国蒂宾根大学博士联合培养) 2014.9-2015.9 Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, USA (美国麻省理工学院访问学者)

研究领域

主要从事抗肿瘤和抗代谢性疾病药物研究，重点开展与性激素代谢紊乱有关的肿瘤(乳腺癌、子宫内膜癌、卵巢癌、前列腺癌等)和老年病(更年期骨质疏松、良性前列腺增生、血脂异常、II型糖尿病等)治疗药物的研究与开发;此外，还从事甾体新药开发及老品种合成工艺改进、甾体新资源的开发和利用

近期论文

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1. Xinge Zhao, Minhang Xin, Yazhou Wang, Wei Huang, Qiu Jin, Feng Tang, Gang Wu, Yong Zhao, Hua Xiang*. Discovery of thieno [3,2-c]pyridin-4-amines as novel Bruton’s tyrosine kinase (BTK) inhibitors. Bioorganic & Medicinal Chemistry, 2015, 23(17): 6059-6068 2. Wenbin Wang, Yi He, Pei Xu, Qidong You, Hong Xiao, Hua Xiang*. Synthesis and biological evaluation of isoflavone amide derivatives with antihyperlipidemic and preadipocyte antiproliferative activities. Bioorganic & Medicinal Chemistry, 2015, 23 (15): 4428-4433 3. Xinge Zhao, Wei Huang, Yazhou Wang, Minhang Xin, Qiu Jin, Jianfeng Cai, Feng Tang, Yong Zhao, Hua Xiang*. Pyrrolo [2,3-b]pyridine derivatives as potent Bruton’s tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry, 2015, 23(15): 4344-4353 4. Xinge Zhao, Wei Huang, Yazhou Wang, Minhang Xin, Qiu Jin, Jianfeng Cai, Feng Tang, Yong Zhao, Hua Xiang*. Discovery of novel Bruton’s tyrosine kinase (BTK) inhibitors bearing a pyrrolo [2,3-d]pyrimidine scaffold. Bioorganic & Medicinal Chemistry, 2015, 23(4): 891-901 5. Xinge Zhao, Minhang Xin, Wei Huang, Yanliang Ren, Qiu Jin, Feng Tang, Hailong Jiang, Yazhou Wang, Jie Yang, Shifu Mo, Hua Xiang*. Design, synthesis and evaluation of novel 5-phenylpyridin-2(1H)-one derivatives as potent reversible Bruton’s tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry, 2015, 23(2): 348-364 6. Tang ZC, Niu SX, Liu F, Lao KJ, Miao JS, Ji JZ, Wang X, Yan M, Zhang LY, You QD, Xiao H, Xiang H*. Synthesis and biological evaluation of 2, 3-diaryl isoquinolinone derivatives as anti-breast cancer agents targeting ERα and VEGFR-2. Bioorg Med Chem Lett. 2014, 24(9): 2129-2133 7. Wang L, Zeng Y, Wang T, Liu H, Xiao H, Xiang H*. Evaluating the potential bioactivity of a novel compound ER1626. PLoS One. 2014, 9(1): 1-9 8. Minhang Xin, Ying Gao, Hua Xiang*, Dong Chen, Yi He, Qidong You. A general and facile synthesis of novel polysubstituted quinazolin-4(3H)-ones. Journal of Heterocyclic Chemistry, 2013, 50(1): 169-174 9. Chen D, Yang K, Xiang H*, Jiang S. New ligands for copper-catalyzed C–N coupling reactions with aryl halides. Tetrahedron Lett, 2012; 53:7121-7124 10. Jie Sun, Hua Xiang*, Lila Yang, Jiabao Chen. A Review on Steroidal 5α-Reductase Inhibitors for Treatment of Benign Prostatic Hyperplasia. Current Medicinal Chemistry, 2011, 18 (23): 3576-3589 11. Wei Zhao, Jie Sun, Hua Xiang*, Yanyan Zeng, Xiaobo Li, Hong Xiao, Deying Chen Renling Ma. Synthesis and biological evaluation of new Flavonoid Fatty Acid Esters with anti-adipogenic and enhancing glucose consumption activities. Bioorganic & Medicinal Chemistry. 2011, 19: 3192–3203 12. Jie Jiao, Hua Xiang*, Qingjiang Liao. Recent advancement in nonsteroidal aromatase inhibitors for treatment of estrogen-dependent breast cancer. Current Medicinal Chemistry, 2010, 17 (30): 3476-3487 13. Hua Xiang*, Wei Zhao, Hong Xiao, et al. Synthesis and biological evaluation of Isoflavone Fatty Acid Esters with potential weight loss and hypolipidemic activities. Bioorganic & Medicinal Chemistry, 2010, 18: 3036–3042 14. Minhang Xin, Qidong You, Hua Xiang*. An efficient, practical synthesis of 2-methoxyestradiol. Steroids, 2010, 75 (1) : 53-56 15. Tianlin Wang, Qidong You, Hua Xiang*. Recent Advances in Selective Estrogen Receptor Modulators for Breast Cancer. Mini-review in medicinal chemistry, 2009, 9, 1191-1201