李志裕 - 中国药科大学

个人简介

教育经历 1996/09-2000/12，中国药科大学，药物化学，博士 1989/09-1991/07，中国药科大学，药物化学，硕士 1984/09-1988/07，中国药科大学，化学制药，学士工作经历 2010/06-至今中国药科大学药化教研室教授 2001/06-2010/05 中国药科大学药化教研室副教授 2001/09-2002/10 意大利University della Carabulia，化学系，博士后 1991/08-2001/05 中国药科大学药化教研室讲师 1991/08-1994/07 中国药科大学药化教研室助教

研究领域

1. 基于天然产物的创新药物研究 2. 小分子抗肿瘤免疫药物的开发 3. 药物绿色合成工艺和晶型研究

近期论文

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Yucheng Tian, Kang Liu, Ruoyi Liu, Zhixia Qiu, Yifan Xu, Wei Wei, Xi Xu, Jubo Wang, Hong Ding, Zhiyu Li*; Jinlei Bian*, Discovery of Potent Small-Molecule USP8 Inhibitors for the Treatment of Breast Cancer through Regulating ERα Expression. Journal of Medicinal Chemistry, 2022, 65: 8914-8932. (IF: 8.039) Xi Xu#; Jubo Wang#; Min Wang; Xinyu Yuan; Lei Li; Chao Zhang; Huidan Huang*; Tian Jing; Chenchen Wang; Chao Tong; Liwen Zhou; Ying Meng; Pengfei Xu; Junping Kou; Zhixia Qiu; Zhiyu Li*; Jinlei Bian*, Structure-Enabled Discovery of Novel Macrocyclic Inhibitors Targeting Glutaminase 1 Allosteric Binding Site, Journal of Medicinal Chemistry, 2021, 64: 4588-4611. (IF: 8.039) Zhen Qin#; Bin Dong#; Renbing Wang; Dechun Huang; Jubo Wang*; Xi Feng; Jinlei Bian*; Zhiyu Li*, Preparing anti-SARS-CoV-2 agent EIDD-2801 by a practical and scalable approach, and quick evaluation via machine learning, Acta Pharmaceutica Sinica B, 2021, 11: 3678-3682. (IF: 14.903) Kai Yuan, Minghui Ji, Shengnan Xie, Zhixia Qiu, Weijiao Chen, Wenjian Min, Fei Xia, Mingming Zheng, Xiao Wang, Jiaxing Li, Yi Hou, Wenbin Kuang, Liping Wang, Wanjian Gu*, Zhiyu Li* and Peng Yang*. Journal of Medicinal Chemistry, 2022, 65: 857-875. (IF: 8.039) Zhen Qin; Lian Qin; Xi Feng; Zhiyu Li*; Jinlei Bian*, Development of Cdc2-like Kinase 2 Inhibitors: Achievements and Future Directions. Journal of Medicinal Chemistry, 2021, 64: 13191-13211. (IF: 8.039) Yucheng Tian#; Jubo Wang#; Xinying Cheng; Kang Liu; Tizhi Wu; Xiaqiu Qiu; Zijian Kuang; Zhiyu Li*; Jinlei Bian*, Microwave-assisted unprotected Sonogashira reaction in water for the synthesis of polysubstituted aromatic acetylene compounds, Green Chemistry, 2020, 22:1338-1344. (IF: 11.034) Xi Feng; Dongdong Liao; Dongyu Liu; An Ping; Zhiyu Li*; Jinlei Bian*, Development of Indoleamine 2,3-Dioxygenase 1 Inhibitors for Cancer Therapy and Beyond: A Recent Perspective, Journal of Medicinal Chemistry, 2020, 63: 15115-15139. (IF: 8.039) Xi Xu; Zijian Kuang; Jie Han; Ying Meng; Lei Li; Hongyu Luan; Pengfei Xu; Jubo Wang; Cheng Luo; Hong Ding; Zhiyu Li*; Jinlei Bian*, Development and Characterization of a Fluorescent Probe for GLS1 and the Application for High-Throughput Screening of Allosteric Inhibitors, Journal of Medicinal Chemistry, 2019, 62: 9642-9657. (IF: 8.039) Tizhi Wu, Zhen Qin, Yucheng Tian, Jubo Wang, Chenxi Xu, Zhiyu Li* and Jinlei Bian*. Recent Developments in the Biology and Medicinal Chemistry of CDK9 Inhibitors: An Update. Journal of Medicinal Chemistry, 2019, 62: 9642−9657. (IF: 8.039) Xi Xu, Ying Meng, Lei Li, Pengfei Xu, Jubo Wang, Zhiyu Li* and Jinlei Bian*.Overview of the Development of Glutaminase Inhibitors: Achievements and Future Directions. Journal of Medicinal Chemistry, 2019, 62: 1096−1115. (IF: 8.039) Qianming Du#; Xi Feng#; Yinuo Wang; Xi Xu; Yan Zhang; Xinliang Qu; Zhiyu Li*; Jinlei Bian*, Discovery of phosphonamidate IDO1 inhibitors for the treatment of non-small cell lung cancer, European Journal of Medicinal Chemistry, 2019, 182: 111629. (IF: 7.088).