个人简介
郝琨，博士，副研究员。1979年6月出生，2008年7月博士毕业于中国药科大学药物代谢动力学实验室，现就职于中国药科大学药代动力学实验室。主要开展药代动力学的研究工作，在此基础上进行药代动力学-药效动力学结合模型方面的科研工作。获得国家自然科学基金资助一项，江苏省自然科学基金项目一项，教育部博士点基金一项, 教育部第46批中国博士后科学基金面上资助二等资助一项，天然药物活性组分与药效国家重点实验室优秀青年科学基金一项。累计在Eur J Pharm Sci，PLoS One， Eur J Pharmacol，Basic & Clinical Pharmacology & Toxicology发表SCI论文16篇，以第一作者发表10篇。发表中文核心期刊9篇，以第一作者发表4篇。研究方向紧密围绕创新药物和天然药物药代动力学及药代动力学-药效动力学结合模型方面。
研究领域
主要开展药代动力学的研究工作，在此基础上进行药代动力学-药效动力学结合模型方面的科研工作
近期论文
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1. Hao K, Qi Q, Hao HP, Liang Y, Xie L, Wang GJ, Sun JG. Prediction of Human Pharmacokinetics from Preclinical Information of Rhein, an Anti-diabetic Nephropathy Drug, Using a Physiologically Based Pharmacokinetic Model. Basic & Clinical Pharmacology & Toxicology. 2014 Feb;114(2):160-7.
2. Hao K, Chen YC, Zhao XP, Liu XQ. Pharmacokinetic-pharmacodynamic model of the antihypertensive interaction between telmisartan and hydrochlorothiazide in spontaneously hypertensive rats. J Pharm Pharmacol 2014 Aug;66(8):1112-21.
3. .Hao K, Qi Q, Hao H, Wang G, Chen Y, Liang Y, Xie L. The pharmacokinetic-pharmacodynamic model of azithromycin for lipopolysaccharide-induced depressive-like behavior in mice. PLoS One. 2013,8(1), e54981.
4. Hao K, Gong P, Sun SQ, Hao HP, Wang GJ, Dai Y, Liang Y, Xie L, Li FY. Mechanism-based pharmacokinetic-pharmacodynamic modeling of the estrogen-like effect of ginsenoside Rb1 on neural 5-HT in ovariectomized mice. Eur J Pharm Sci. 2011,44(1-2),117-126.
5. Hao K, Gong P, Sun SQ, Hao HP, Wang GJ, Dai Y, Liang Y, Xie L, Li FY. Beneficial estrogen-like effects of ginsenoside Rb1, an active component of Panax ginseng, on neural 5-HT levels and behavior in ovariectomized mice. Eur J Pharmacol. 2011,659(1),15-25.
6. Hao K, Chen YC, Cao YG, Yu D, Liu XQ, Wang GJ. Pharmacokinetic- pharmacodynamic modeling of telmisartan using an indirect response model in spontaneously hypertensive rats. Acta Pharmacologica Sinica. 2007, 28,(5),738-743.
7. Hao K, Liu XQ, Wang GJ, Zhao XP. Pharmacokinetics, Tissue Distribution and Excretion of Gambogic Acid in Rats. European Journal of Drug Metabolism and Pharmacokinetics. 2007,32(2),63-68.
8. Hao K, Zhao XP, Liu XQ, Wang GJ. Determination of gambogic acid in dog plasma by high-performance liquid chromatography for a pharmacokinetic study. Biomedical Chromatography. 2007,21(3),279-283.
9. Hao K, Zhao XP, Liu XQ, Wang GJ. Determination of curcumin in dog plasma by HPLC for a pharmacokinetic study. Chromatographia. 2006,64(9-10),531-535.
10. Hao K, Cao YG, Zhao YN, Mao GG, Liu XQ, Wang GJ. Bioequivalence of Helicidum Administered in Single Dose to Healthy Chinese Male Volunteers. Drug Research. 2007, 57(8),522-525.
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