廖红 - 中国药科大学 - 药物科学研究院

个人简介

廖红，女，博士，教授，博士生和硕士生导师。1987年获南京大学生物系理学学士学位，1990年获南京大学神经化学理学硕士学位，2004年获中国药科大学药理学博士学位。1990-2002年在南京大学医学院病理生理学教研室工作，2005年至今在中国药科大学药物科学研究院新药筛选中心工作，任新药筛选中心党支部书记。现为美国生物化学和分子生物学学会(ASBMB)会员，关注阿尔茨海默病研究与治疗的国际科学协会（ISTAART）会员，同时为中国神经科学会和中国药理学会的会员。2002年8月到新加坡中央医院神经生物学研究室作为研究科学家工作三年。目前与德国Hamberg大学、德国Saarland大学、澳大利亚Monash大学、澳大利亚南澳大学合作开展有关神经退变病的机制和药物开发的研究。主持多项国家自然科学基金、江苏省自然科学基金、江苏省的国际合作项目和江苏省留学归国人员科技活动项目择优资助的等多项基金项目，作为主要参与者参与了“十一五”国家重大新药创制等多个项目。共发表论文63篇，SCI有32篇。并拥有一项发明专利证书。

研究领域

具体研究领域：主要从事药物对阿尔茨海默病和中风的影响及机理研究；胶质细胞在神经损伤与再生中的作用及机理研究；以及药物对神经干细胞增殖和分化的影响及机理研究

近期论文

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[1].Chen T, Wang J, Li C, Zhang L, An L, Pang T, Shi X, Liao H Nafamostat mesilate attenuates neuronal damage in a rat model of transient focal cerebral ischemia through thrombin inhibiton. Scientific Reports 2014 Jul 2;4:5531. doi: 10.1038/srep05531. [2].Liu M, Guo J, Wang J, Zhang L, Pang T, Liao H Bilobalide induces neuronal differentiation of P19 embryonic carcinoma cells via activating Wnt/β-catenin pathway. Cell Mol Neurobiol 2014; 34(6):913-23 [3].Guo J, Wang J, Liang C, Yan J, Wang Y, Liu G, Jiang Z, Zhang L, Wang X, Wang Y, Zhou X, Liao H. proNGF inhibits proliferation and oligodendrogenesis of postnatal hippocampal neural stem/progenitor cells through p75NTR in vitro. Stem Cell Res. 2013; 11:874-87. [4].Guo J, Wang J, Zhang Z, Yan J, Chen M, Pang T, Zhang L, Liao H. proNGF inhibits neurogenesis and induces glial activation in adult mouse dentate gyrus. Neurochem Res. 2013;38:1695-703 [5].Chen Y, Sun J, Huang Z, Liao H, Peng S, Lehmann J, Zhang Y. Design, synthesis and evaluation of tacrine-flurbiprofen-nitrate trihybrids as novel anti-Alzheimer's disease agents.Bioorg Med Chem. 2013; 21:2462-70. [6].Sun J, Fang Y, Chen T, Guo J, Yan J, Song S, Zhang L, Liao H WIN55, 212-2 promotes differentiation of oligodendrocyte precursor cells and improve remyelination through regulation of the phosphorylation level of the ERK 1/2 via cannabinoid receptor 1 after stroke-induced demyelination; Brain Res. 2013; 1491:225-35. [7].Sun J, Fang YQ, Ren H, Chen T, Guo JJ, Yan J, Song S, Zhang LY, Liao H WIN55,212-2 protects oligodendrocyte precursor cells in stroke penumbra following permanent focal cerebral ischemia in rats; Acta Pharmacol Sin. 2013 ;34:119-28. [8].Fan Y, Sun K, Mao L, Liao H, Wang H The expression of PGC-1a in the mice brain after traumatic brain injury. Brain Injury.2012; 26:1267–1272 [9].Chen Y, Sun J, Fang L, Liu M, Peng S, Liao H Lehmann J, Zhang Y. Tacrine−Ferulic Acid−Nitric Oxide (NO) Donor Trihybrids as Potent,Multifunctional Acetyl- and Butyrylcholinesterase Inhibitors. J Med Chem. 2012, 55:4309− 4321 [10].Guo J,Niu R, Huang W, Zhou M, Shi J, Zhang L,Liao H Growth Factors from Tumor Microenvironment Possibly Promote the Proliferation of Glioblastom a-Derived Stem- like Cells in Vitro. Pathol Oncol Res.2012,18:1047–1057 [11].Yan J, Zhou X, Guo J, Mao L, Wang Y, Sun J, Sun L, Zhang L, Zhou X, Liao H Nogo-66 inhibits adhesion and migration of microglia via GTPase Rho pathway in vitro. J Neurochem.2012,120:721-731 [12].Chen Y, Fang L, Peng S, Liao H, Lehmann J, Zhang Y Discovery of a novel acetylcholinesterase inhibitor by structure-based virtual screening techniques. Bioorganic & Medicinal Chemistry Letters, 2012,22:3181–3187 [13].Mao L, Wang H, Wang X, Liao H, Zhao X; Transcription Factor Nrf2 Protects the Spinal Cord from Inﬂammation Produced by Spinal Cord Injury. Journal of Surgical Research,2011,170: e105–e115 [14].Liao H, Sanjaya Mani D; Advances in Oligoprotection. Neuroscience & Medicine , 2011, 2:93-10 [15].Wong I, Liao H, Bai X, Zaknic A, Zhong J, Guan Y, Li Y, Wang Y, Zhou X; ProBDNF inhibits inﬁltration of ED1+ macrophages after spinal cord injury; Brain, Behavior, and Immunity ,2010,24:585–597 [16].Liao H, Huang W, Niu R, Sun L, Zhang L. Cross-talk between the epidermal growth factor-like repeats/fibronectin 6-8 repeats domains of Tenascin-R and microglia modulates neural stem/progenitor cell proliferation and differentiation.J Neurosci Res. 2008 Jan;86(1):27-34. [17].Liao H, Huang W, Schachner M, Guan Y, Guo J, Yan J, Qin J, Bai X, Zhang L. beta 1 integrin mediated effects of tenascin-R domains EGFL and FN6-8 on neural stem/progenitor cell proliferation and differentiation in vitro. J. Biol. Chem. 2008, 283(41): 27927-27936 [18].Liao H,Bu W, Wang T, Ahmed S, and Xiao ZC Tenascin-R plays a role in neuroprotection via its distinct domains coordinately modulating the microglia function. J. Biol. Chem. 2005: 280(9)：8316-8323 [IF: 5.8] [19] Tan XW, Liao H, Sun L, Masaru O, Xiao ZC and Dawe XW FetalMicrochimerism in the Maternal Mouse Brain: A Novel Population of Fetal Progenitor or Stem Cells Able to Cross the Blood-Brain Barrier? Stem Cells, 2005, 23(10):1443-1452[IF: 7.6] [20] Liao H, Duka T, Teng FY, Sun L, Bu W, Ahmed S,Tang BL and Z.C. Xiao Nogo-66 and myelin- associated glycoprotein (MAG) inhibit the adhesion and migration of Nogo-66 receptor expressing human glioma cells. J.Neurochem2004, 90(5)： 1156－62 [IF: 4.2]