李飞 - 中国药科大学 - 天然药物活性组分与药效国家重点实验室

个人简介

李飞，男，博士，副教授，博士生导师，2013年毕业于中国药科大学中药学专业，获理学博士学位，并于同年留校任教至今。作为课题负责人，先后主持国家自然科学基金青年基金、江苏省自然科学基金青年基金和中央高校基本科研业务项目等课题3项，主持或作为子课题负责人参与并完成医药公司技术服务项目3项，参与十一五和十二五国家重大新药创制专项、国家自然科学基金重点项目、国家自然科学基金面上项目、国家药典委员会项目等课题十余项，指导大学生创新计划项目2项。近年来在国内外学术刊物包括Int J Nanomed、Phytomedicine、Appl Therm Eng、J Pharmaceut Biomed、Am J Chinese Med、RSC Adv、J Ethnopharmacol、J Chromatogr B、J Sep Sci、Drug Des Dev Ther、Drug Dev Ind Pharm、Nat Prod Res、Phytother Res、Int Immunopharmacol和Fitoterapia等杂志发表论文40余篇，其中SCI收录32篇；第一作者或通讯作者发表SCI论文26篇；申请发明专利2项。

研究领域

（1）中药有效成分发现与评价研究；（2）中药炮制机理研究；（3）中药新药开发研究。

近期论文

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(1) Shen J-Y, Bi J-P, Tian H-L, Jin Y, Wang Y, Yang X-L, Yang Z-L, Kou J-P*, Li F*. Preparation and evaluation of a self-nanoemulsifying drug delivery system loaded with Akebia saponin D-phospholipid complex.Int J Nanomed. 2016, 11: 4919-4929. (2) Guo C-R∗, Shen J-Y, Meng Z-Q, Yang X-L, Li F∗. Neuroprotective effects of polygalacicacid on scopolamine-induced memory deficits in mice. Phytomedicine. 2016, 23: 149-155. (3) Li F#, Yang X-L#, Yang Y-N, Guo C-R, Zhang C-F*, Yang Z-L*, Li P. Antiosteoporotic activity of echinacoside in ovariectomized rats. Phytomedicine, 2013, 20: 549-557. (4) Zhang W-J#, Dong C-L#, Wang J-Y, He X, Yang X-L, Fu Y-F, Zhang C-F*, Li F*, Wang C-Z, Yuan C-S. Thermal effects on the dissolution enhancement of Radix scutellariae by wine-processing. Appl Therm Eng. 2016, 103: 522-527. (5) Li F#, Cheng T-F#, Dong X, Li P*, Yang H*. Global analysis of chemical constituents in Shengmai injection using high performance liquid chromatography coupled with tandem mass spectrometry. J Pharm Biomed Anal. 2016, 117:61-72. (6) Yang M, Yang X-L, An J-M, Xiao W, Wang Z-Z, Huang W-Z, Yang Z-L*, Li F*. Comparative pharmacokinetic profiles of tectorigenin in rat plasma by UPLC-MS/MS after oral administration of Iris tectorum Maxim extract and pure tectoridin. J Pharm Biomed Anal. 2015, 114:34-41. (7) Yuan Y-L, Lin B-Q, Zhang C-F, Cui L-L, Ruan S-X, Yang Z-L*, Li F*, De Ji. Timosaponin B-II Ameliorates Palmitate-Induced Insulin Resistance and Inflammation via IRS-1/PI3K/Akt and IKK/NF-κB Pathways.Am J Chinese Med. 2016, 44: 755-769. (8) Zhang W-J, Wang J-Y, Li H, He X, Zhang R-Q, Zhang C-F*, Li F*, Yang Z-L, Wang C-Z, Yuan C-S. Novel application of natural anisole compounds as enhancers for transdermal delivery of ligustrazine. Am J Chin Med. 2015, 43:1231-46. (9) Shen J-Y, Jin Y, Tian H-L, Wang Y, Yang X-L, Yang Z-L, Guo C-R*, Li F*. Enhancement of oral bioavailability of akebia saponin D by destroying self-micelles and inhibiting multidrug resistance-associated protein mediated efflux. RSC Adv. 2016, 6: 72439-72446. (10) Sun YY#, Zhang WJ#, Dong CL, Zhang XF, Ji J, Wang X, Wang L, Hu WL, Du WJ, Cui CL, Zhang CF*, Li F*, Wang CZ, Yuan CS. Baicalin Alleviates Nitroglycerin-induced Migraine in Rats via the Trigeminovascular System. Phytother Res. 2017, 31(6):899-905. (11) Du W-J, Yang X-L, Song Z-J, Wang J-Y, Zhang W-J, He X, Zhang R-Q, Zhang C-F*, Li F*, Yu C-H, Wang C-Z, Yuan C-S. Antitumor activity of total flavonoids from daphne genkwa in colorectal cancer. Phytother Res. 2016, 30 (2):323-30. (12) Pan T#, Cheng TF#, Jia YR, Li P*, Li F*.Anti-rheumatoid arthritis effects of traditional Chinese herb couple in adjuvant-induced arthritis in rats. J Ethnopharmacol. 2017, 9 (205):1-7. (13) Wang X, Song Z-J, He X, Zhang R-Q, Zhang C-F*, Li F*, Wang C-Z, Yuan C-S. Antitumor and immunomodulatory activity of genkwanin on colorectal cancer in the APCMin/+ mice. Int Immunopharmacol. 2015, 29:701-7. (14) Shen J-Y#, Yang X-L#, Yang Z-L, Kou J-P*, Li F*. Enhancement of absorption and bioavailability of echinacoside by verapamil or clove oil. Drug Des Dev Ther. 2015, 9: 4685-4693. (15) Yuan Y-L#, Guo C-R#, Cui L-L, Ruan S-X, Zhang C-F, Ji D, Yang Z-L*, Li F*. Timosaponin B-II ameliorates diabetic nephropathy via TXNI P, mTOR, and NF-κB signaling pathways in alloxan-induced mice. Drug Des Dev Ther. 2015, 9: 6247-6258. (16) Wang J-Y#, Ji J#, Song Z-J, Zhang W-J, He X, Li F*, Zhang C-F*, Guo C-R,Wang C-Z, Yuan C-S. Hypocholesterolemic effect of emodin by simultaneous determination of in vitro and in vivo bile salts binding. Fitoterapia. 2016, 110: 116-122. (17) Li F, Yang Y, Zhu P, Chen W, Qi D, Shi X, Zhang C, Yang Z, Li P. Echinacoside promotes bone regeneration by increasing OPG/RANKL ratio in MC3T3-E1 cells. Fitoterapia.2012, 83: 1443-1450. (18)Li F#, Sun X-Y#, Li X-W, Yang T, Qi L-W*. Enrichment and separation of quercetin-3-O-β-D-glucuronide from lotus leaves (Nelumbo nucifera Gaertn.) and evaluation of its anti-inflammatory effect. J Chromatogr B. 2017,1040:186-191. (19) Cheng T-F, Jia Y-R, Zuo Z, Dong X, Zhou P, Li P*, Li F*. Quality assessment of traditional Chinese medicine herb couple by high-performance liquid chromatography and mass spectrometry combined with chemometrics. J Sep Sci.2016, 39: 1223-1231. (20) Zhou P-P#, Yang X-L#, Zhang C-F, Yang Z-L*, Li F*. Method to evaluate the quality of herbal medicines based on the dynamic changes of chemical compounds and pharmacological activity. J Sep Sci. 2016, 39: 3661-3668

学术兼职

天然药物活性组分与药效国家重点实验室课题组成员，“十二五”普通高校国家级规划教材《中药炮制学》和《中药炮制学实验与指导》编委，中国中药协会（China Association of Traditional Chinese Medicine）中药饮片质量保障专业委员会青年委员。