钱海 - 中国药科大学 - 药物科学研究院

个人简介

2007年7月-2010年5月药学院讲师 2010年6月-2015年5月药物科学研究院副教授 2015年6月-药物科学研究院研究员 2020年6月-理学院院长

研究领域

主要从事创新药物分子发现和结构优化研究。针对糖尿病、肿瘤、疼痛等重大临床问题，以多肽、核酸和小分子药物为研究对象，基于药物靶点及药物分子本身的结构特点进行合理设计，并从受体、细胞及整体动物等不同层面深入探讨和确证相关化合物的药效机制，为创新药物开发奠定坚实基础。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Source and exploration of the peptides used to construct peptide-drug conjugates 2021-11-01 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 第一通讯作者 Design, synthesis and immunological evaluation of self-assembled antigenic peptides from dual-antigen targets: a broad-spectrum candidate for an effective antibreast cancer therapy 2021-06-01 JOURNAL FOR IMMUNOTHERAPY OF CANCER 独立通讯 Structure-Based Discovery of Pyrimidine Aminobenzene Derivatives as Potent Oral Reversal Agents against P-gp- and BCRP-Mediated Multidrug Resistance 2021-05-01 JOURNAL OF MEDICINAL CHEMISTRY 独立通讯 Discovery of Potent Inhibitors against P-Glycoprotein-Mediated Multidrug Resistance Aided by Late-Stage Functionalization of a 2-(4-(Pyridin-2-yl)phenoxy)pyridine Analogue 2020-05-01 JOURNAL OF MEDICINAL CHEMISTRY 第二通讯作者 Synthetic tumor-specific antigenic peptides with a strong affinity to HLA-A2 elicit anti-breast cancer immune response through activating CD8(+) T cells 2020-03-01 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 独立通讯 Development of cell-permeable peptide-based PROTACs targeting estrogen receptor alpha 2020-02-01 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 独立通讯 Design, Synthesis, and Pharmacological Characterization of N-(4-(2 (6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)yl)ethyl)phenyl)quinazolin-4- amine Derivatives: Novel Inhibitors Reversing P-Glycoprotein-Mediated Multidrug Resistance 2017-04-01 JOURNAL OF MEDICINAL CHEMISTRY 第一通讯作者 Exploration of 2-((Pyridin-4-ylmethyl)amino)nicotinamide Derivatives as Potent Reversal Agents against P-Glycoprotein-Mediated Multidrug Resistance 2017-04-01 JOURNAL OF MEDICINAL CHEMISTRY 第一通讯作者 Novel coumarin modified GLP-1 derivatives with enhanced plasma stability and prolonged in vivo glucose-lowering ability 2014-12-01 BRITISH JOURNAL OF PHARMACOLOGY 第二通讯作者 Design, Synthesis, and Biological Activity of Novel Dicoumarol Glucagon-like Peptide 1 Conjugates 2013-12-01 JOURNAL OF MEDICINAL CHEMISTRY 第二通讯作者