近期论文
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1. Zengwei Lai, Chunhong Li, Jun Liu, Lingyi Kong, Xiaoan Wen,* Hongbin Sun.* Discovery of Highly Potent DPP-4 Inhibitors by Hybrid Compound Design Based on Linagliptin and Alogliptin. European Journal of Medicinal Chemistry 2014, 83, 547-560.
2. Jizhe Dong, Yanchun Gong, Jun Liu, Xiangfeng Chen, Xiaoan Wen,* Hongbin Sun.* Synthesis and biological evaluation of all eight stereoisomers of DPP-IV inhibitor saxagliptin. Bioorganic & Medicinal Chemistry 2014, 22, 1383-1393.
3. Dongyin Chen, Chang Xu, Jie Deng, Chunhuan Jiang, XiaoanWen, Lingyi Kong, Ji Zhang,* Hongbin Sun,*Proton-exchanged montmorillonite-mediated reactions of methoxybenzyl esters and ethers. Tetrahedron2014, 70, 1975-1983.
4. Xiaowei Sun, Chengzhe Gao, Fan Zhang, Zhuang Song, Lingyi Kong, Xiaoan Wen, Hongbin Sun.* Electronic and Steric Effects on the Intramolecular Schmidt Reaction of Alkyl Azides with Secondary Benzyl Alcohols.Tetrahedron2014, 70, 643-649.
5. Zeng-Wei Lai, Rong-Fei Yang, Ke-Yin Ye, Hongbin Sun,* Shu-Li You.* Synthesis of 1-[bis(trifluoromethyl)phosphine]-1’-oxazolinylferrocene ligands and their application in regio- and enantioselective Pd-catalyzed allylic alkylation of monosubstituted allyl substrates. Beilstein Journal of Organic Chemistry2014, 10, 1261-1266.
6. Xueli Zhang, Yanli Tian, Zeng Li, Xiaoyu Tian, Hongbin Sun, Hong Liu, Anna Moore, Chongzhao Ran*. Design and synthesis of curcumin analogues for in vivo fluorescence imaging and inhibiting copper-induced cross-linking of amyloid Beta species in Alzheimer's disease. J. Am. Chem. Soc. 2013, 135, 16397-409.
7. Jia Hao,Jun Liu, Xiaoan Wen, Hongbin Sun.* Synthesis and cytotoxicity evaluation of oleanolic acid derivatives.Bioorganic & Medicinal Chemistry Letters2013, 23, 2074-2077.
8. Jiaqi Shan, Hongbin Sun.* The discovery and development of Prasugrel. Expert Opinion on Drug Discovery2013, 8, 897-905.
9. Jia Hao,Jun Liu, Xiaoan Wen, Hongbin Sun.* Synthesis and cytotoxicity evaluation of oleanolic acid derivatives.Bioorganic & Medicinal Chemistry Letters2013, 23, 2074-2077.
10. Jiaqi Shan, Boyu Zhang, Yaoqiu Zhu, Bo Jiao, Weiyi Zheng, Xiaowei Qi, Yanchun Gong,Fang Yuan, Fusheng Lv, Hongbin Sun.* Overcoming Clopidogrel Resistance: Discovery of Vicagrel as a Highly Potent and Orally Bioavailable Antiplatelet agent. Journal of Medicinal Chemistry2012, 55, 3342–3352.(获Nature旗下刊物SciBX的亮点报道)
11. Jia Hao,Bo Chen,Yiwu Yao, Murad Hossain, Takafumi Nagatomo, Hequan Yao,Lingyi Kong, Hongbin Sun.* Practical access to four stereoisomers of naftidrofuryl and their binding affinity towards 5-hydroxytryptamine 2A receptor. Bioorganic & Medicinal Chemistry Letters2012, 22, 3441-3444.
12. Hao Zhang, Jun Liu, Luyong Zhang, Lingyi Kong, Hequan Yao, Hongbin Sun.*Synthesis and biological evaluation of ticagrelor derivatives as novel antiplatelet agents. Bioorganic & Medicinal Chemistry Letters2012, 22, 3598-3602.
13. Liying Zhang, Yingxia Zhang, Jizhe Dong, Jun Liu*, Luyong Zhang, Hongbin Sun.*Design and synthesis of novel photoaffinity probes for study of the target proteins of oleanolic acid. Bioorganic & Medicinal Chemistry Letters2012, 22, 1036-1039.
14. Jun Xia, Jiabin Li, Hongbin Sun.* Insights into ETA subtype selectivity of benzodiazepine endothelin receptor antagonists by 3D-QSAR approaches. Journal of Molecular Modeling2012, 18, 1299-1311.
15. Huaming Sheng,Hongbin Sun.* Synthesis, Biology and Clinical Significance of Pentacyclic Triterpenes: a Multi-target Approach to Prevention and Treatment of Metabolic and Vascular Diseases. Natural Product Reports 2011, 28, 543-593.
16. Zhangyu Yao, Xueying Wei, Xiaoming Wu, Jonathan L. Katz, Theresa Kopajtic, Nigel H. Greig, Hongbin Sun.*Preparation and Evaluation of Tetrabenazine Enantiomers and All Eight Stereoisomers of Dihydrotetrabenazine as VMAT2 Inhibitors. European Journal of Medicinal Chemistry 2011, 46, 1841-1848.
17.Zhongjie Liang, Liying Zhang, Lianchun Li, Jun Liu, Honglin Li, Luyong Zhang,Keguang Cheng, Xiaoan Wen, Pu Zhang, Jia Hao, Yanchun Gong, Xia Zhang, Jun Chen, Hong Liu, Cheng Luo, Hualiang Jiang,Hongbin Sun.* Pentacyclic Triterpenes Derivatives as Potent Inhibitors against Glycogen Phosphorylase: the Receptor-Based 3D-QSAR Guided Inhibitor Optimization. European Journal of Medicinal Chemistry 2011, 46, 2011-2021.
18. Yong Wu, Chen Shi, Xiaowei Sun, Xiaoming Wu, Hongbin Sun.* Synthesis, biological evaluation and docking studies of octane-carboxamide based renin inhibitors with extended segments toward S3’ site of rennin.Bioorganic & Medicinal Chemistry2011, 19, 4238-4249.
19. Pu Zhang, Li Xu, Keduo Qian, Jun Liu, Luyong Zhang, Kuo-Hsiung Lee, Hongbin Sun.* Efficient synthesis and biological evaluation of epiceanothic acid and related compounds. Bioorganic & Medicinal Chemistry Letters2011, 21, 338-341.
20. Jun Xia , Jianfei Song, Le Zhen, Xiuling Zhang, Xiantao Lei, Lina Zheng, Qiujuan Wang, Hongbin Sun.* Synthesis and in vitro evaluation of ambrisentan analogues as potential endothelin receptor antagonists. Bioorganic & Medicinal Chemistry Letters2011, 21, 3894-3897.