张广钦 - 中国药科大学 - 基础医学与临床药学学院

个人简介

受教育经历 2001/10-2003/10，北京大学，生命科学学院，博士后 1997/09-2001/06, 中国药科大学,药学院，博士 1989/09-1992/06,中国药科大学,药学院，硕士 1982/09-1985/06, 河南大学，药学系研究工作经历 2009/10-2010/11，新加坡国家心脏中心，研究科学家 2005/01-2006/01，香港科技大学，生化系，博士后 2001/10-2003/10，北京大学，生命科学学院，博士后 2004/11-目前，中国药科大学,药学院，副研究员 1992/07-2001/09，中国药科大学,药学院，讲师 1985/8-1989/8，河南商丘地区中医院，药剂师

研究领域

1.心肌和神经细胞离子通道研究以及细胞钙信号转导。 2.诱导性多潜能干细胞(iPS)定向心肌细胞分化的研究

近期论文

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1.Zhang GQ, Wei H, Lu J, Wong P, Shim W. Identification and characterization of calcium sparks in cardiomyocytes derived from human induced pluripotent stem cells. PLoS One. 2013;8(2):e55266. 2.Wei H, Zhang G, Qiu S, Lu J, Sheng J, Manasi, Tan G, Wong P, Gan SU, Shim W.Hydrogen sulfide suppresses outward rectifier potassium currents in human pluripotent stem cell-derived cardiomyocytes. PLoS One. 2012;7(11):e50641.(并列作者). 3.Ma D, Wei H, Lu J, Ho S, Zhang G, Sun X, Oh Y, Tan SH, Ng ML, Shim W, Wong P, Liew R.Generation of patient-specific induced pluripotent stem cell-derived cardiomyocytes as a cellular model of arrhythmogenic right ventricular cardiomyopathy. Eur Heart J. 2013；34(15):1122-33.. 4.Shim W, Mehta A, Lim SY, Zhang G, Lim CH, Chua T, Wong P.G-CSF for stem cell therapy in acute myocardial infarction: friend or foe? Cardiovasc Res. 2011;89(1):20-30. 5.Zhang GQ, Qiu SH, Wei HM.Scutellarin blocks sodium current in freshly isolated mouse hippocampal CA1 neurons. Neurochem Res. 2011, 36:947-54. 6.Zhang GQ, Wang H, Liu WT, Dong H, Fong WF, Tang LM, Xiong YH, Yu ZL, Ko KM.Long-Term Treatment with a Chinese Herbal Formula, Sheng-Mai-San, Improves Cardiac Contractile Function in Aged Rats: The Role of Ca2+ Homeostasis.Rejuvenation Res. 2008, 11: 991-1000. 7.Zhang GQ, Huang XD, Wang H, Leung AK, Chan CL, Fong DW, Yu ZL. Anti-inflammatory and analgesic effects of the ethanol extract of Rosa multiflora Thunb. hips. J Ethnopharmacol. 2008;118:290-4. 8.Fu Y, Zhang GQ, Hao XM, Wu CH, Chai Z, Wang SQ. Temperature dependence and thermodynamic properties of Ca2+ sparks in rat cardiomyocytes.Biophys J. 2005;89:2533-41 9.Zhang Guangqin, Fu Yu, Yang Dongmei, Hao Xuemei, Bai Shuhua, Tang Yiqun, Edward G Lakatta, Cheng Heping. Contribution of Spontaneous L-type Ca2+ channel activation to the genesis of Ca2+ sparks in resting cardiac myocyte. Science in China (C) 2004;47(1):31-8 10.ZHANG Guang-Qin, HAO Xue-Mei, DAI De-Zai, FU Yu, ZHOU Pei-Ai, WU Cai-Hong. Puerarin blocks Na+ current in isolated rat ventricular myocytes. Acta Pharmacol Sin 2003; 24(12): 1212-6 11.ZHANG Guang-Qin, HAO Xue-Mei, CHEN Shi-Zhong, ZHOU Pei-Ai, CHENG He-Ping, WU Cai-Hong. Blockade of paeoniflorin on sodium current in mouse hippocampal CA1 neurons. Acta Pharmacol Sin. 2003; 24(12):1248.-52 12.G-Q Zhang, X-M Hao, P-A Zhou, C-H Wu. Effect of paeonol on L-type calcium channel in rat ventricular myocytes. Mothods Find Exp Clin Pharmacol 2003; 25(4):281-5 13.ZHANG Guang-Qin, HAO Xue-Mei, ZHOU Pei-Ai, WU Cai-Hong, DAI De-Zai.Puerarin blocks transient outward K+ current and delayed rectifier K+ current in mice hippocampal CA1 neurons. Acta Pharmacol Sin 2001; 22(3):253-6. 14.Zou L.Y., Hao X.M., Zhang G.Q., Zhang M., Guo J.H., Liu T.F.: Effect of Tetramethyl Pyrazine on L-type Calcium Channel in Rat Ventricular Myocytes. Can. J. Physiol. Pharmacol 2001; 79: 621-6.