李霁 - 中国药科大学 - 基础医学与临床药学学院

个人简介

李霁，博士，副教授，硕士生导师。2010年获中国药科大学药理学博士学位。2013-2014年获国家公派赴美国University of California, San Francisco(UCSF) 从事博士后研究。主持国家自然科学基金青年项目(81503133); 教育部高等学校博士学科点专项科研基金(20130096120003);参加国家自然科学基金面上项目(81570413);国家自然科学基金面上项目(81573385)。

研究领域

药理学方向-肝肾纤维化发病机制和药物作用靶点的研究；水通道蛋白(AQPs) 在纤维化上皮细胞间充质细胞转分化(EMT)过程中的作用研究；中药肝肾毒性机制研究。临床药学方向:-特殊人群用药安全性问题及特殊人群体内/外代谢动力学研究。

近期论文

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Li, Ji, et al., The potential role of aquaporin 1 on aristolochic acid I induced epithelial mesenchymal transition on HK-2 cells. J Cell Physiol, 2018. 233(6): p. 4919-4925.  Ji Li, Liang Zhang, Zhenzhou Jiang, Xiuqin He, Luyong Zhang, Ming Xu*. Expression of Renal Aquaporins in Aristolochic Acid I and Aristolactam I-Induced Nephrotoxicity. Nephron, 2016, 133(3):213-221. Li Ji，Larregieu, Caroline A.; Benet, Leslie Z. Classification of natural products as sources of drugs according to the biopharmaceutics drug disposition classification system (BDDCS). Chin J Nat Med, 2016. 14(12): p. 888-897. Liang Zhang#, Ji Li#, Zhenzhou Jiang, Lixin Sun, Xue Mei, Bian Yong and Luyong Zhang*. Inhibition of aquaporin-1 expression by RNAi protects against aristolochic acid I-induced apoptosis in human proximal tubular epithelial (HK-2) cells[J]. Biochem Biophys Res Commun. 2011 Feb 4;405(1):68-73. Ji Li, liang Zhang, Zhenzhou Jiang, Bin Shu, Fu Li, Qingli Bao, and Luyong Zhang*. Toxicities of aristolochic acid I and aristololactam I in cultured renal epithelial cells[J]. Toxicol In Vitro. 2010 Jun;24(4):1092-7. Qing Li#, Ji Li#, Hua Shao, Xiao-xue Li, Feng Yu*, Ming Xu*. Inhibition of CPU0213, a Dual Endothelin Receptor Antagonist, on Apoptosis via Nox4-Dependent ROS in HK-2 Cells[J]. Cell Physiol Biochem, 2016, 39(1):183-192. Yong Mao, Mincheng Zhang, Jiapei Yang, Hao Sun, Dandan Wang, Xiaoxia Zhang, Feng Yu and Ji Li*. The UCP2-related mitochondrial pathway participates in rhein-induced apoptosis in HK-2 cells[J].Toxicology Research, 2017, Advance Article. Mei Xue ,Zhen-zhou Jiang,Tao Wu, Ji Li, Liang Zhang , Yan Zhao , Xue-jun Li , Lu-Yong Zhang, Shu-yu Yang. Anti-inflammatory effects and hepatotoxicity of Tripterygium-loaded solid lipid nanoparticles on adjuvant-induced arthritis in rats.Internationaljournal of Phytotherapy and Phytopharmacology, 2012,19(11):998-1006 Li Sun,Yang Liu,Sensen Lin,Jing Shang,Jin Liu，Ji Li，Shengtao Yuan,Luyong Zhang. Early growth response gene-1 and hypoxia-inducible factor-1 affect tumor metastasis via regulation of tissue factor. Acta oncologica. 2013,52(4)