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Wang, J. #, Wang, Y. #,Cui, W.W. #, Huang, Y. #, Yang, Y., Liu, Y., Zhao, W.S., Cheng, X.Y.,Sun, W.S., Cao, P., Zhu, M.X., Wang, R.*, Hattori, M.*, Yu, Y.*(2018). Druggable negative allosteric site of P2X3 receptors. PNAS. 115(19) 4939-4944.
Gabriele Stephan; Lumei Huang; Yong Tang; Sandra Vilotti; Elsa Fabbretti; Yu, Y.; Wolfgang Nörenberg; Heike Franke; Flóra Göröncsér; Beáta Sperlágh; Anke Dopychai; Ralf Hausmann; Günther Schmalzing; Patrizia Rubini; Peter Illes. (2018).The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel. Nat. Commun. 9(1).
Yang, X.N., Niu, Y.Y., Liu,Y. Yang,Y. Wang,J., Cheng, X.Y., Liang, H., Wang, H.S., Hu,Y.M., Lu. X.Y., Zhu, M.X., Xu, T.L., Tian, Y., Yu, Y* (2017).The nonproton ligand of acid-sensing ion channel activates mollusk-specific FaNaC channels via a mechanism independent of native FMRFamide peptide.J Biol Chem. 292(52):21662-21675.
Wang, J., Sun, L.F., Cui, W.W., Zhao, W.S., Ma, X.F., Li, B., Liu, Y., Yang, Y., Hu, Y.M., Huang, L.D., Cheng, X.Y., Li, L., Lu, X.Y., Tian, Y.*, Yu, Y* (2017). Intersubunit physical couplings fostered by the leftflipperdomain facilitate channel opening of P2X4 receptors. J Biol. Chem., 292(18):7619-7635.
Kasuya, G., Yamaura, T., Ma, X.B., Nakamura, R., Takemoto, M., Nagumo, H., Tanaka, E.,Dohmae, N., Nakane, T., Yu, Y., Ishitani, R., Matsuzaki, O., Hattori, M., Nureki1, O. (2017). Structural insights into the competitive inhibition of the ATP-gated P2X receptor channel. Nat Commun,(1):876.
Zhao, W.S. #,Sun, M.Y.#, Sun, L.F., Liu. Y., Yang. Y., Huang, L.D., Fan, Y.Z., Cheng. X.Y., Cao, P., H, Y.M., Li, L.Y., Tian, Y., Wang, R.*,Yu, Y.* (2016).A Highly Conserved Salt-bridge Stabilizes the Kinked Conformation of β2,3-sheet Essential for Channel Function of P2X4 Receptors. J Biol Chem.291 (15): 7990-8003
Niu, Y.Y. #,Yang, Y. #,Liu, Y., Huang, L.D., Yang, X.N., Fan Y.Z., Cheng, X.Y., Cao, P., Hu Y.M., Li, L.Y., Lu, X.Y.,Tian, Y.*, Yu, Y.* (2016). Exploration of the Peptide-recognition of an Amiloride-sensitive FMRFamide Peptide-gated Sodium Channel. J Biol Chem.291 (14): 7571-82
Wang, J., Yu, Y.* (2016). Insights into channel gating of P2X receptors from structures, dynamics and small molecules. Acta Pharmacol Sin. (Invited review). 37(1):44-55.
Zhao, W.S., Wang, J., Ma, X.J., Yang, Y., Liu, Y., Huang, L.D., Fan, Y.Z., Cheng, X.Y., Chen, H.Z., Wang, R.*,Yu, Y.* (2014). Relative motions between left flipper and dorsal fin domains favour P2X4 receptor activation.Nat Commun, 5:4189.
Yu, Y. #, Li, W.G. # (#equal contribution), Chen, Z., Jiang, H.L., Xu, T.L. (2011). Atomic level characterization of the nonproton ligand-sensing domain of ASIC3 channel. J Biol Chem, 286:24996-5006.
Yu, Y#., Chen, Z.#, Li, W.G. (#equal contribution), Cao, H., Feng, E.G., Yu, F., Liu, H., Jiang H.L.*, & Xu, T.L.* (2010). A nonproton ligand sensor in the acid-sensing ion channel.Neuron,68(1), 61-72.
& Commented in “Small molecule ion channel match making: a natural fit for new ASIC ligands”, Bagriantsev, S.N. and Minor, D.L. Jr. Neuron, 68:1-3.
Yang, H.#, Yu, Y.# (#equal contribution), Li, W.G., Yu, F., Cao, H., Xu, T.L.*, Jiang, H.L.* (2009). Inherent dynamics of the acid-sensing ion channel 1 correlates with the gating mechanism.PLOS Biology, 7:e1000151.
Yang, H.#, Yu, Y.# (#equal contribution), Li, W.G., Xu, T.L.*, & Jiang, H.L.* (2009). Conformational sampling on acid-sensing ion channel 1 (ASIC1): implication for a symmetric conformation.Cell Research, 19: 1035-1037.
Yu, Y., Shao, X., Cui, Y., Liu, H.M., Wang, C.L., Fan, Y.Z., Liu, J., Dong, S.L., Cui, Y. X., Wang, R.* (2007). Structure–activity study on the spatial arrangement of the third aromatic ring of endomorphins 1 and 2 using an atypical constrained C terminus.ChemMedChem, 2: 309-317.
Yu, Y., Cui, Y., Wang, X., Lai, L.H., Wang, C.L., Fan, Y.Z., Liu, J., Wang, R.* (2007). In vitro characterization of the effects of endomorphin 1 and 2, endogenous ligands for mu-opioid receptors, on mouse colonic motility.Biochem Pharmacol, 73:1384-93.
Yu, Y., Shao, X., Wang, C.L., Liu, H.M., Cui, Y., Fan, Y.Z., Liu, J., Dong, S.L., Wang, R.* (2007). In vitro and in vivo characterization of opioid activities of endomorphins analogs with novel constrained C-terminus: evidence for the important role of proper spatial disposition of the third aromatic ring.Peptides, 28: 859-870.
Yu, Y., Wang, C.L., Cui, Y., Fan, Y.Z., Liu, J., Shao, X., Liu, H.M., Wang, R.* (2006). C-terminal amide to alcohol conversion changes the cardiovascular effects of endomorphins in anesthetized rats.Peptides,27: 136-143.