谭树华 - 中国药科大学 - 生命科学与技术学院

个人简介

谭树华, 中国药科大学生化药学博士，美国University of Nebraska Medical Center医学细胞与分子生物学博士后，教授，博士生导师。历任中国药科大学生物制药教研室副教授、副主任、主任，江苏省生化与分子生物学会理事。先后主持承担了国家新药研究基金项目、国家自然科学基金青年基金项目、国家自然科学基金面上项目、国家“重大新药创制”科技重大专项“十一五”及“十二五”计划项目、国家教育部霍英东教师奖励基金项目、国家教育部留学回国人员基金项目、江苏省 “六大人才高峰”项目、江苏省科技厅项目、南京市留学人员科技活动择优资助项目、技术成果转化及校企合作开发项目等。在国际SCI及国内核心学术期刊发表学术论文50余篇，获得国家及省级鉴定成果3项（主持1项，参加2项），试生产批文1项，申请中国发明专利12项。荣获第七届江苏省青年科技奖、江苏省科技进步三等奖、江苏省轻工业厅科技进步特等奖、美国University of Nebraska Medical Center杰出表现津贴奖(FY2005~06)等奖项。入选江苏省“333”新世纪学术带头人。讲授本科生“分子生物学”、“生物药学基础与前沿”（新生研讨课）、中英合作班“Cell and Molecular Biology”等课程，以及研究生“药物生物技术研究进展”、留学硕士生“Advances in Molecular Biology”等课程。为本科生讲授的“生物工程”课程荣获江苏省高等学校I类优秀课程奖及精品课程奖，指导研究生完成的科技作品荣获全国第七届大学生“挑战杯”竞赛一等奖。主编《药学分子生物学》（中国医药科技出版社）、《分子生物学实验指导》（中国医药科技出版社），副主编《生物技术制药概论》（中国医药科技出版社）、《生物制药技术》（化学工业出版社），共同编写《生物工程》（中国医药科技出版社）。

研究领域

1.生物新药的基础与应用研究 2.基因工程与蛋白质工程关键技术研究 3.药物相关基因的表达与调控研究 4.生物药物靶向分子与技术研究

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1.L. Gu, P. Ye, H. Li, Y. Wang, Y. Xu, Q. Tian, G. Lei, C. Zhao, Z. Gao, W. Zhao, S. Tan*, Lunasin attenuates oxidant-induced endothelial injury and inhibits atherosclerotic plaque progression in ApoE(-/-) mice by up-regulating heme oxygenase-1 via PI3K/Akt/Nrf2/ARE pathway. FASEB J 33 (2019) 4836-4850. 2.G. Lei, M. Xu, Z. Xu, C. Lu, S. Tan*, Combination of novel DR5 targeting agonistic scFv antibody TR2-3 with cisplatin shows enhanced synergistic antitumor activity in vitro and in vivo. Biomed Pharmacother 98 (2018) 271-279. 3.L. Gu, Y. Wang, Y. Xu, Q. Tian, G. Lei, C. Zhao, Z. Gao, Q. Pan, W. Zhao, L. Nong, S Tan*, Lunasin functionally enhances LDL uptake via inhibiting PCSK9 and enhancing LDLR expression in vitro and in vivo,Oncotarget 8 (2017) 80826-80840. 4.G. Lei, M. Xu, Z. Xu, L. Gu, C. Lu, Z. Bai, Y. Wang, Y. Zhang, H. Hu, Y. Jiang, W. Zhao, S. Tan*, A Novel Fully Human Agonistic Single Chain Fragment Variable Antibody Targeting Death Receptor 5 with Potent Antitumor Activity In Vitro and In Vivo, Int J Mol Sci, 18 (2017). 5.Q. Tian, P. Zhang, Z. Gao, H. Li, Z. Bai, S. Tan*, Hirudin as a novel fusion tag for efficient production of lunasin in Escherichia coli, Prep Biochem Biotechnol, 47 (2017) 619-626. 6.J. Zhu, Q. Zhou, S. Tan*, Targeting miRNAs associated with surface expression of death receptors to modulate TRAIL resistance in breast cancer, Cancer Lett, 383 (2016) 154-160. 7.G. Dai, P. Zhang, P. Ye, M. Zhang, N. Han, H. Shuai, S. Tan*, The Chemopreventive Peptide Lunasin Inhibits d-Galactose- Induced Experimental Cataract in Rats, Protein Pept Lett, 23 (2016) 619-625. 8.S. Setrerrahmane, Y. Zhang, G. Dai, J. Lv, S. Tan*, Efficient production of native lunasin with correct N-terminal processing by using the pH-induced self-cleavable Ssp DnaB mini-intein system in Escherichia coli, Appl Biochem Biotechnol, 174 (2014) 612-622. 9.X. Gong, Q. Zhang, S. Tan*, Inhibitory effect of r-hirudin variant III on streptozotocin-induced diabetic cataracts in rats, ScientificWorldJournal, 2013 (2013) 630651. 10.H. Zhang, P. Dramou, H. He, S. Tan*, C. Pham-Huy, H. Pan, Molecularly imprinted stationary phase prepared by reverse micro-emulsion polymerization for selective recognition of gatifloxacin in aqueous media, J Chromatogr Sci, 50 (2012) 499-508. 11.L. Shen, Z. Liu, F. Xie, X. Zhang, S. Tan*, A novel approach for secretion of heterologous proteins with correct n-terminal processing by using alpha-factor pre sequence in Pichia pastoris, Protein Pept Lett, 19 (2012) 1005-1009. 12.J. Lv, C. Huang, X. Zhang, S. Tan*, Extracellular secretion of anticoagulant peptide hirudin in Lactococcus lactis using SP310mut2 signal peptide, Biotechnol Lett, 34 (2012) 61-65. 13.C. Huang, X. Zhang, J. Qu, P. Zhang, S. Tan*, Robust preparative-scale extracellular production of hirudin in Escherichia coli and its purification and characterization, J Ind Microbiol Biotechnol, 39 (2012) 1487-1494. 14.Z. Chen, D. Pierre, H. He, S. Tan*, C. Pham-Huy, H. Hong, J. Huang, Adsorption behavior of epirubicin hydrochloride on carboxylated carbon nanotubes, Int J Pharm, 405 (2011) 153-161. 15.S. Tan*, W. Wu, X. Li, L. Cui, B. Li, Q. Ruan, Enhanced secretion of adhesive recognition sequence containing hirudin III mutein in E. coli, Mol Biotechnol, 36 (2007) 1-8. 16.S. Tan, P.W. Cheng, Mucin biosynthesis: identification of the cis-regulatory elements of human C2GnT-M gene, Am J Respir Cell Mol Biol, 36 (2007) 737-745. 17.P. Radhakrishnan, P.V. Beum, S. Tan, P.W. Cheng, Butyrate induces sLex synthesis by stimulation of selective glycosyltransferase genes, Biochem Biophys Res Commun, 359 (2007) 457-462. 18.M. Hashimoto, S. Tan, N. Mori, H. Cheng, P.W. Cheng, Mucin biosynthesis: molecular cloning and expression of mouse mucus-type core 2 beta1,6 N-acetylglucosaminyltransferase, Glycobiology, 17 (2007) 994-1006. 19.K.N. Nemec, A.H. Pande, S. Qin, R.J. Bieber Urbauer, S. Tan, D. Moe, S.A. Tatulian, Structural and functional effects of tryptophans inserted into the membrane-binding and substrate-binding sites of human group IIA phospholipase A2, Biochemistry, 45 (2006) 12448-12460. 20.A.H. Pande, D. Moe, K.N. Nemec, S. Qin, S. Tan, S.A. Tatulian, Modulation of human 5-lipoxygenase activity by membrane lipids, Biochemistry, 43 (2004) 14653-14666. 21.S. Tan, W. Wu, J. Liu, Y. Kong, Y. Pu, R. Yuan, Efficient expression and secretion of recombinant hirudin III in E. coli using the L-asparaginase II signal sequence, Protein Expr Purif, 25 (2002) 430-436.

学术兼职

现任分子生物学教研室主任，江苏省生物技术协会常务理事、副秘书长, 国家自然科学基金项目审评专家，国家教育部留学回国人员科研基金评审专家，多个国际SCI期刊杂志编委及审稿人。