施志浩 - 中国药科大学

个人简介

施志浩，副教授，1978年12月出生，博士，2007年毕业于南京理工大学，同年进入中国药科大学理学院有机教研室工作至今。于2015年4月至2016年4月作为访问学者赴加拿大多伦多大学进行为期一年的研究工作, 主要学习金属催化剂在构建杂环分子合成中的应用。现主要研究方向为小分子抗肿瘤药物的设计与合成及基于天然产物结构的活性小分子化合物的结构改造与修饰。

研究领域

主要学习金属催化剂在构建杂环分子合成中的应用。现主要研究方向为小分子抗肿瘤药物的设计与合成及基于天然产物结构的活性小分子化合物的结构改造与修饰。

近期论文

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Zhi-Hao Shi, Feng-Tao Liu, Hao-Zhong Tian, Yan-Min Zhang, Nian-Guang Li*, Tao Lu*. Design, synthesis and structure-activity relationship of diaryl-ureas with novel isoxazol[3,4-b]pyridine-3-amino-structure as multi-target inhibitors against receptor tyrosine kinase. Bioorganic & Medicinal Chemistry,2018, 26(16), 4735–4744. Wenyu Wu, Shaopeng Yu, Ting Gu, Tianyuan Fan, Yue Zhong, Nian-Guang Li*, Yuping Tang*, Yi Jiang, Xingmei Zhu, Jinao Duan*,Zhihao Shi*. Norbornene Mediated Palladium-Catalyzed Domino-Type Catellani Reaction: An Efficient and Regiospeciﬁc Acylation/Suzuki Coupling of Aryl Iodides. European Journal of Organic Chemistry, 2018, 24, 3075–3085. Yue Zhong, Yu-Ting Lu, Ying Sun, Zhi-Hao Shi, Nian-Guang Li*, Yu-Ping Tang* and Jin-Ao Duan. Recent opportunities in matrix metalloproteinase inhibitor drug design for cancer. Expert Opnionon Drug Discovery, 2018, 13(1), 75–87. Juntao Ye, Zhihao Shi, Theresa Sperger, Yoshifumi Yasukawa, Cian Kingston,Franziska Schoenebeck* and Mark Lautens*. Remote C−H alkylation and C−C bond cleavageenabled by an in situ generated palladacycle. Nature Chemistry, 2017, 9(4), 361–368. Khan T. Osman, Juntao Ye, Zhihao Shi, Christina Toker, Diogo Lovato, Rajiv S. Jumani, William Zuercher, Christopher D. Houston, Aled M. Edwards, Mark Lautens*, Vijayaratnam Santhakumar*, Raymond Hui*. Discovery and structure activity relationship of the first potent cryptosporidium FIKK kinase inhibitor. Bioorganic & Medicinal Chemistry,2017, 25(5), 1672-1680. Wen-Yu Wu, Yu-Chen Dai, Nian-Guang Li*, Ze-Xi Dong, Ting Gu, Zhi-Hao Shi, Xin Xue, Yu-Ping Tang*,and Jin-Ao Duan*. Novel multitarget-directed tacrine derivatives as potential candidates for thetreatment of Alzheimer’s disease. Journal of Enzyme Inhibition and Medicinal Chemistry,2017, 32(1), 572-587. Wei Zhang, Nian-Guang Li*, Yu-Ping Tang, Ze-Xi Dong, Ting Gu, Wen-Yu Wu, Peng-Xuan Zhang,Shao-Peng Yu, Jin-Ao Duan and Zhi-Hao Shi*. Investigation of 6-O-methyl-scutellareinmetabolites in rats by ultra-flow liquidchromatography/quadrupole-time-of-flight massspectrometry. Pharmaceutical Biology, 2016, 54(10), 2158-2167. Ze-Xi Dong, Zhi-Hao Shi, Nian-Guang Li*,Wei Zhang, Ting Gu, Peng-Xuan Zhang,Wen-Yu Wu, Yu-Ping Tang*, Fang Fang, XinXue, He-Min Li, Hai-Bo Cheng, Jian-PingYang and Jin-Ao Duan.*Design, Synthesis, and Biological Evaluation ofScutellarein Derivatives Based on Scutellarin MetabolicMechanism In Vivo. Chemical Biology & Drug Design,2016, 87(6), 946–957. Zhang Wei, Dong Ze-Xi, Gu Ting, Li Nian-Guang*, Wu Wen-Yu, Zhang Peng-Xuan, Tang Yu-Ping, Yang Jian-Ping, Xue Xin, Fang Fang, Li He-Min, Cheng Hai-Bo, Duan Jin-Ao, Shi Zhi-Hao. An improved synthesis of 6-O-methyl-scutellarein through selective benzylation. Journal of Chemical Research, 2015, 39(11), 674-676.