杜鼎 - 中国药科大学

个人简介

杜鼎，教授，博士生导师，2009年博士毕业于南开大学元素有机化学研究所，2013-2014年美国密歇根大学访问学者。理学院副院长，江苏省“青蓝工程”优秀青年骨干教师。从事“有机化学”理论和实验教学，国际班“有机化学”精品课程负责人；主编《大学化学基础及实验》、《有机化学实验与指导（第三版）》等教材；获校级教学成果奖一等奖一项，江苏省教学成果奖二等奖一项，主持校级及省级多项教改课题。

研究领域

1）生物活性分子导向的催化不对称合成 2）功能分子的精准合成 3）绿色合成工艺开发与优化 4）小分子药物设计与开发

近期论文

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Chen Lin, Simiao Zhang, Jingyi Wang, Lei Chen, Yiwei Zhu,* Ding Du.* N-Heterocyclic Carbene-Catalyzed Enantioselective Synthesis of Carbocycle-Fused Uracils via Formal [4 + 2] Annulation/Lactone Formation/Decarboxylation Cascade. Org. Lett. 2022, 24, 3631. Lei Chen, Chen Lin, Simiao Zhang, Xiaojin Zhang, Jianming Zhang, Lianjie Xing, Yage Guo, Jie Feng,* Jian Gao, Ding Du.* 1,4-Alkylcarbonylation of 1,3-Enynes to Access Tetra-Substituted Allenyl Ketones via an NHC-Catalyzed Radical Relay. ACS Catal. 2021, 11, 13363. Lei Chen,# Shiyi Jin,# Jian Gao, Tongtong Liu, Yuebo Shao, Jie Feng,* Kangyi Wang, Tao Lu, Ding Du.* N-Heterocyclic carbene/Magnesium Cocatalyzed Radical Relay Assembly of Aliphatic Keto Nitriles. Org. Lett. 2021, 23, 394. Rui Ma, # Xiaoxue Wang, # Qiaoyu Zhang, Lei Chen, Jian Gao, Jie Feng, Donghui Wei,* Ding Du.* Atroposelective synthesis of axially chiral 4-aryl alfa-carbolines via N-heterocyclic carbene catalysis. Org. Lett. 2021, 23, 4267-4272. Shaohua Hou, Xiping Yang, Yu Tang, Yuejing Yang, Quanwei Chen, Boheng Wan, Ran Wei, Yuchen Wang, Yanmin Zhang, Bo Kang, Jianhang Huang, Yadong Chen, Tao Lu,* Qinghua, Hu,* Ding Du.* Structure-based discovery of 1H-indole-2-carboxamide derivatives as potent ASK1 inhibitors for potential treatment of ulcerative colitis. Eur. J. Med. Chem. 2021, 211, 113114. Ding Du,* Kuili Zhang, Rui Ma, Lei Chen, Jian Gao, Tao Lu, Zhihao Shi,* Jie Feng.* Bio- and Medicinally Compatible α‑Amino-Acid Modification via Merging Photoredox and N‑Heterocyclic Carbene Catalysis. Org. Lett. 2020, 22, 6370. Jian Gao, Jianming Zhang, Shuaishuai Fang, Jie Feng, Tao Lu, Ding Du.* Synergistic N-heterocyclic carbene/palladium-catalyzed [3+2] annulation of vinyl enolates with 1-tosyl-2-vinylazirdine. Org. Lett. 2020, 22, 7725.