张大永 - 中国药科大学

个人简介

张大永（Da-Yong Zhang），博士，教授，博士生导师。现任职中国药科大学理学院副院长（分管科研及国际交流工作，联系各科研平台）。毕业于中国科学技术大学化学物理系（有机化学专业，获硕士学位）、中国药科大学药学院（药物化学专业，获博士学位），中国农工民主党党员，江苏省“六大人才高峰”人才培养对象，教育部学位与研究生教育评估专家，“十二五”、“十三五”国家“重大新药创制”科技重大专项评审专家，国家自然科学基金评议专家，农业部国家兽药评审专家等。曾任职国家级连云港经济技术开发区副主任，中国药科大学连云港研究院院长，无锡（马山）国家生命科学园管委会副主任，太湖国家旅游度假区管委会主任助理，南京师范大学化学与环境科学学院教授等。主持多项省级、国家级各种研究、攻关项目及企业联合研究、开发项目，已发表几十篇SCI研究论文，申请发明专利二十多项。多种国内、国际核心期刊（SCI期刊）编审。主要讲授《药物设计》、《高等药物化学选论》、《药物立体化学》等本科、硕士、博士课程。目前已拥有近20名硕士、博士研究生的研究团队，主要从事于医药、农药及其中间的基础研究和应用开发研究以及工业化批量生产

研究领域

重大疾病药物的创制及其生物学研究。靶向抗肿瘤药物、抗糖尿病药物以及抗病毒药物的设计、合成及其生物活性研究。新农药活性化学分子的设计、合成及其生物活性研究。旨在寻找到高效、低毒、环境友好的实体化合物用于杀虫剂、除草剂、杀菌剂、抗藻等。医药、农药及其中间体等精细化学品的合成工艺研究及工业化途径研究

近期论文

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Xinxin Zheng, Rui Guo, Guozhu Zhang, Dayong Zhang. Rhodium(I)-catalyzed asymmetric [4+2] cycloaddition reactions of 2-alkylenecyclobutanols with cyclic enones through C-C bond cleavage: efficient access to trans-bicyclic compounds[J]. Chemical Science, 2018, 9(7): 1873-1877. Yi-Qian Li, Qi-Liang Yang, Ping Fang, Tian-Sheng Mei, Dayong Zhang. Palladium-Catalyzed C(sp2)-H Acetoxylation via Electrochemical Oxidation[J]. Org. Lett. 2017, 19, 2905-2908. Rui Guo, Xinxin Zheng, Dayong Zhang ,Guozhu Zhang.Rhodium(I)-catalyzed stereoselective [4+2] cycloaddition of oxetanols with alkynes through C(sp3)–C(sp3) bond cleavage[J]. Chemical Science, 2017, 8, 3002-3006. MOU Yi, JIAN Yan-Lin, CHEN Tong, HUANG Zhang-Jian, QIAO Yi-Xue, PENG Si-Xun, ZHANG Da-Yong, JI Hui, ZHANG Yi-Hua. Synthesis and evaluation of 2-cyano-3, 12-dioxooleana-1, 9(11)-en-28-oate-13β, 28-olide as a potent anti-inflammatory agent for intervention of LPS-induced acute lung injury[J]. Chin J Nat Med, 2017, 15(5): 347-354. Yanlin Jian, Jing Ji, Zhangjian Huang, Yang Gao, Xiao Sheng, Wei Yin, Dayong Zhang, Hui Ji, Yihua Zhang. Enantiomers of 3-pentylbenzo[c] thiophen- 1(3H)-one: preparation and evaluation of anti-ischemic stroke activities [J]. RSC Adv., 2016, 6, 36888-36897. Ke Wang, Yang-Chang Wu, Juan-Cheng Yang, Meng-Han Zhang, Mohame El-Shazly, Da-Yong Zhang, Xiao-Ming Wu. Synthesis of Novel 3,19-Dihydroxyjolkinolides and Related Derivatives Starting from Andrographolide[J]. Synthesis, 2016, 48, A–J. Yan Luo, Ke Wang, Meng-han Zhang, Da-yong Zhang, Yang-chang Wu, Xiao-ming Wu, Wei-yi Hua. Synthesis of new ent-labdane diterpene derivatives from andrographolide and evaluation on cytotoxic activities[J]. Bioorg. Med. Chem. Lett. 25 , 2015, 2421-2424. Liangwei Zhang, Xiangdong Li, Yuanhong Liu, Dayong Zhang. Palladium-catalyzed highly efficient synthesis of functionalized indolizines via cross-coupling/cycloisomerization cascade[J] Chem. Commun., 2015,51, 6633-6636 . Yiwu Yao, Zheng Li, Yatao Qiu, Jinhong Bai, Jinyue Su1, Dayong Zhang, Sheng Jiang. Unprecedented reactions: from epichlorohydrin to epoxyglycidyl substituted divinyl ether and its conversion into epoxyglycidyl propargyl ether[J]. Scientific Reports, 5, 14231. Chang-Zhen Zhu,Ke Wang, Meng-han Zhang, Da-Yong Zhang, Yang-Chang Wu,Xiao-Ming Wu, Wei-Yi Hua.Efficient Synthesis of Jolkinolides A and B from Steviol[J]. Synthesis, 2014, 46, 2574-2578. Jinyue Su, Yatao Qiu, Kun Ma, Yiwu Yao, Zhen Wang, Xianling Li, Dayong Zhang, Zhengchao Tu d,, Sheng Jiang.Design, synthesis, and biological evaluation of largazole derivatives: alteration of the zinc-binding domain[J].Tetrahedron, 2014,70, 7763-7769. Jinyue Su, Yatao Qiu, Sheng Jiang, Dayong Zhang. New Ligands for Copper-Catalyzed C-N Coupling Reactions at Gentle Temperature[J]. Chin. J. Chem. 2014, 32, 685-688. ZOU Min, YU Shuang-Shuang, WANG Ke, ZHANG Da-Yong,WU Xiao-Ming, HUA Wei-Yi.Glycosylation of ent-kaurene derivatives and an evaluation of their cytotoxic activities[J].Chin J Nat Med,2013,11(3): 289-295. Feifei Wu, ShiguangGao, Zhiyin Chen, Jinyue Su, Dayong Zhang. An efficient synthesis of 2-(2, 2-difluoroethoxy)-6-trifluoromethyl-(5,8-dimethoxy-1,2,4-triazolo[1,5-c]pyrimidine-2-yl) benzenesul-fonamide: penoxsulam[J]. J Chem Res, 2013, 37(4): 197-200.