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个人简介

2016年9月-至今,南京师范大学生命科学学院,副教授 2011年10月-2016年8月,南京师范大学生命科学学院,讲师 2006年9月-2011年6月,南京师范大学,生命科学学院,理学博士 1999年9月-2003年6月,信阳师范学院,生命科学学院,理学学士

研究领域

非编码RNA(包括miRNA和LncRNA)在代谢性疾病和肿瘤中的调控作用

近期论文

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Guo, L.*, Liang, T.*, microRNAs and their variants in an RNA world: implications for complex interactions and diverse roles in an RNA regulatory network, Brief Bioinform ,2017, doi: 10.1093/bib/bbw124, in press. (Co-Corresponding author) Guo, L., Zhang, Q., Ma, X., Wang, J., Liang, T.*, miRNA and mRNA expression analysis reveals potential sex-biased miRNA expression. 2017, Sci Rep, 7, 39812. (Corresponding author) Guo, L., Liang, T., Yu, J., Zou, Q.*, A comprehensive analysis of miRNA/isomiR expression with gender difference, PLoS ONE, 2016, 11(5), e0154955. Zhang, W., Wang, P., Chen, S., Zhang, Z., Liang, T.,* and Liu, C.,*. Rhythmic expression of miR-27 targets the clock gene bmal1 through post-transcriptional regulation in the mouse liver. 2016, FASEB Journal 30, 2151-2160. (Co-Corresponding author) Guo, L.*, Yu, J., Liang, T., Zou, Q., miR-isomiRExp: a web-server for the analysis of expression of miRNA at the miRNA/isomiR levels, Sci Rep, 2016, 6, 23700. doi:10.1038/srep23700. Liang, T., Yu, J., Liu, C., Guo, L.,*. IsomiR expression patterns in Canonical and Dicer-independent miRNAs, 2017, Mol Med Rep, 15:1071-1078. Liang, T., Yang, C., Li, P., Liu, C. and Guo, L.,*. Genetic analysis of loop sequences in the let-7 gene family reveal a relationship between loop evolution and multiple isomiRs. 2014. PLoS One 9, e113042. Liang, T., Yu, J., Liu, C. and Guo, L.,*. An exploration of evolution, maturation, expression and function relationships in mir-23 - 27 - 24 cluster. 2014. PLoS One 9, e106223. Liang, T.,* Liu, C. and Ye, Z., Deep sequencing of small RNA repertoires in mice reveals metabolic disorders-associated hepatic miRNAs. 2013. PLoS One 8, e80774. (Corresponding author) Liang, T., Guo, L. and Liu, C.,*. Genome-wide analysis of mir-548 gene family reveals evolutionary and functional implications. 2012. J Biomed Biotechnol 2012, 679563. Liang, T., Ji, H., Du, J., Ou, J., Li, W., Wu, T., Meng, Q., Gu, W. and Wang, W.,*. Primary culture of hemocytes from Eriocheir sinensis and their immune effects to the novel crustacean pathogen Spiroplasma eriocheiris. 2012. Mol Biol Rep 39, 9747-9754. (IF:1.958) Liang, T., Wu, T., Du, J., Ji, H., Li, Y., Gu, W. and Wang, W., Characterization of a tailless white spot syndrome virus from diseased Penaeus vannamei and Procambarus clarkii in China. 2011. Afr J Biotechnol 10, 13936-13942. Liang, T., Li, X., Du, J., Yao, W., Sun, G., & Dong, X., et al. Identification and isolation of a spiroplasma pathogen from diseased freshwater prawns, macrobrachium rosenbergii , in china: a new freshwater crustacean host. 2011.Aquaculture, 318, 1, 1–6. Liang, T., Ji, H., Lian, L., Wu, T., Gu, W., & Wang, W. A rapid assay for simultaneous detection of spiroplasma eriocheiris and white spot syndrome virus in procambarus clarkii by multiplex pcr. 2010. Lett Appl Microbiol, 51, 5, 532–538. Liang, T., Qi Feng, Ting Wu, Wei Gu, Wen Wang*. Use of oxytetracycline for the treatment of tremor disease in the Chinese mitten crab (Eriocheir sinensis). 2009. Dis Aquat Organ 84:243-250. Guo, L. #*, Li, H. #, Liang, T. #, Lu, J., Yang, Q., Ge, Q. and Lu, Z.,*. Consistent isomiR expression patterns and 3' addition events in miRNA gene clusters and families implicate functional and evolutionary relationships. 2012. Mol Biol Rep 39, 6699-706. Ge, X., Chen, S., Liu, M., Liang, T., Liu, C. Evodiamine inhibits pdgf‑bb‑induced proliferation of rat vascular smooth muscle cells through the suppression of cell cycle progression and oxidative stress. (2016). Mol Medicine Rep 14:4551-4558 Ge X, Chen S, Liu M, Liang T, Liu C*, Evodiamine Attenuates PDGF-BB-induced Migration of Rat Vascular Smooth Muscle Cells through Activating PPARγ, 2015. Int J Mol Sci,16(12):28180-28193. Chen, S., Ding, Y., Tao, W., Zhang, W., Liang, T. and Liu, C.,*. Naringenin inhibits TNF-α induced VSMC proliferation and migration via induction of HO-1. 2012. Food Chem Toxicol. 50, 3025-3031. Chen, S., Qian, J., Shi, X., Gao, T., Liang, T. and Liu, C.,*. Control of hepatic gluconeogenesis by the promyelocytic leukemia zinc finger protein. 2014. Mol Endocrinol. 28, 1987-1998.

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