陈玉清 - 南京师范大学

个人简介

陈玉清：女，1974年6月出生，四川成都人。2000年毕业于四川农业大学生化与分子生物学专业，获理学硕士学位；2007年南京师范大学动物学专业博士研究生毕业，获理学博士学位；2014年美国耶鲁大学医学院实验医学系访问学者。在南京师范大学“青蓝工程”优秀青年骨干教师培养对象（2012-2015），南京师范大学“优秀教师奖”（2013），曾承担本科生专业基础课《生物化学》《生物化学实验》《分子生物学》《分子生物学实验》《生物学进展》以及研究生《基因工程下游技术》《细胞工程》《高级生物化学》等多门课程的教学工作。

研究领域

对病源微生物感染机体后免疫应答产生的免疫小肽分别从生物化学、细胞生物学以及生化药理学等角度研究其生物学活性，尤其关注其在人类恶性肿瘤治疗中的效应与分子机制。关注蛋白质修饰对抗癌活性的影响与机理，为寻找高抗癌活性低毒副作用的药物提供重要依据和方向。近年研究兴趣主要包括： 1. 抗菌肽生物学功能及抗菌抗癌的分子机制 2. 抗菌肽修饰改造、抗癌活性与分子机制 3. 抗菌免疫肽与抗肿瘤免疫的关系与机制

近期论文

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Zhang TT, Gonzalez DG, Cote CM, Kerfoot SM, Deng S, Chen YQ, Magari M, Haberman AM. Germinal center B cell development has distinctly regulated stages completed by disengagement from T cell help. Elife. 2017 May 12;6. pii: e19552. doi: 10.7554/eLife.19552 (SCI) Shi W, Li CY, Li M, Zong XC, Han DJ, Chen YQ*. Antimicrobial peptide melittin against Xanthomonas oryzae pv. oryzae, the bacterial leaf blight pathogen in rice. Applied Microbiology and Biotechnology. 2016, 100(11), 5059-5067 (SCI收录) Sang M, Zhang JX, Li B*, Chen YQ*. TRAIL-CM4 fusion protein shows in vitro antibacterial activity and a stronger antitumor activity than solo TRAIL protein. Protein Expression and Purification. 2016, 122:82-89 (SCI收录) Han YY, Liu HY, Han DJ, Zong XC, Zhang SQ, Chen YQ*. Role of glycosylation in the anticancer activity of antibacterial peptides against breast cancer cells. Biochemical Pharmacology. 2013, 86(9): 1254–1262 (SCI收录) Liu HY, Han YY, Fu HY, Liu M, Wu J, Chen XN, Zhang SQ, Chen YQ*. Construction and expression of sTRAIL–melittin combining enhanced anticancer activity with antibacterial activity in Escherichia coli. Applied Microbiology and Biotechnology. 2013, 97(7):2877-84 (SCI收录) Min C, Wang Q, Chen YQ*, Zhang SQ, Yao ZG, Ding YH, Ren YJ. cDNA cloning and recombinant expression of a proliferation inducing ligand (APRIL) from Père David’s deer. Research in Veterinary Science. 2012, 92:240–242, 2012 (SCI收录) Min C, Han YY, Liu HY, Chen YQ*, Zhang SQ, Yao ZG, Ding YH. cDNA cloning, recombinant expression and bioactivity of Père David's deer BAFF. Gene. 505(2):233-239, 2012. (SCI收录) Min C, Liang ZN, Cui XW, Wang Q, Chen YQ*, Zhang SQ. Molecular cloning and partial functional characterization of a proliferation inducing ligand (APRIL) in zebrafish (Danio rerio). Developmental and Comparative Immunology. 2012, 37(1):202-206 (SCI收录) Li JF, Zhang J, Xu XZ, Han YY. Cui XW, Chen YQ, Zhang SQ. The antibacterial peptide ABP-CM4: the current state of its production and applications. Amino Acids. 2012, 42(6):2393-402 (SCI收录) Shen YF, Wang SL, Ai HX, Min C, Chen YQ*, Zhang SQ. Molecular structure, bioinformatics analysis, expression and bioactivity of BAFF (TNF13B) in dog (Canis familiaris). Veterinary Immunology and Immunopathology. 2011, 142:133–139 (SCI收录) Chen YQ*, Min C, Sang M, Han YY, Ma X, Xue XQ, Zhang SQ. A cationic amphiphilic peptide ABP-CM4 exhibits selective cytotoxicity against leukemia cells. Peptides. 2010, 31:1504–1510 (SCI收录) Chen YQ, Ren GJ, An SQ, Sun QY, Liu CH and Shuang JL. Bacterial community changes after the colonization of Phragmites in copper mine tailings. Pedosphere. 2008, 18(6): 731-740 (SCI收录) Chen YQ, Zhang SQ*, Li BC, Qiu W, Jiao B, Zhang J, Diao ZY. Expression of a cytotoxic cationic antibacterial peptide in Escherichia coli using two fusion partners. Protein Expression and Purification. 2008,57:303-311. (SCI收录)