陈龙 - 南京师范大学

个人简介

陈龙男，汉族，安徽安庆人，研究生学历，博士学位。南京师范大学教授、博士生导师。美国癌症协会（AACR）、中国生理学会、中国生化与分子生物学会、中国细胞生物学会、中国病理生理学会、中国畜牧兽医学会会员；江苏省神经科学学会常务理事、生理科学学会理事、细胞和发育生物学学会理事。World J Gastroenterol、World J Exp Med、Open Vet Sci J等刊物编委。Acta Pharmacol Sin、Acupunct Med、Am J Physiol-Cell Ph、Brit J Pharmacol、Pharmacol Rep、Cancer Chemother Pharmacol、Cancer Invest、Cell Mol Neurobiol、Cytokine、Front Physiol、IUBMB Life、Histol Histopathol、Hum Exp Toxicol、J Dairy Res、J Hazard Mater、J Leukoc Biol、J Pharm Pharmacol、Oncotarget、Peptides、Pharm Biol、Vaccine等刊物审稿人。学习和工作经历 1981－1985年安徽农业大学动物医学系动物医学专业学士；1987－1988年武汉大学生物化学系访问学者；1991－1998 年南京农业大学动物医学院生理学与生物化学专业硕士、博士；1997年德国Hanover动物医学院合作访问学者；2000－2001年南京医科大学公共卫生学院江苏省应用毒理重点实验室访问学者；2006－2008年美国Louisiana州立大学卫生科学中心生化与分子生物学系博士后访问学者。 1985－1998年安徽科技学院动物医学系助教、讲师、副教授，1998年8月作为高层次人才引进南京师范大学生命科学学院，曾先后担任动物教研中心主任、生物学系主任、生命科学学院副院长等职务，2001年破格晋升为教授。现为生命科学学院生理学与生物化学教授，生化与分子生物学博士点学科研究方向带头人，生理学硕士点学科带头人

研究领域

从免疫生理学与生物化学、病理生理学角度揭示机体、组织、细胞损伤与抗损伤保护的免疫学机制和分子机制——致力于细胞生存和死亡的信号转导网络研究，探索靶向药物调控分子机制。特别关注氧化应激、环境化学污染物镉影响人类健康如大脑神经元凋亡、退化及其相关疾病的发生机理及调控和新药探索；神经－内分泌－免疫网络中的多信号分子的相互关系及调控策略，为指导有益免疫应答、避免有害应答，寻找和开发新型免疫活性调节因子提供新思路和新方法；肿瘤发生中相关信号分子在其粘附、迁移中的作用，为寻找靶向抑制药物提供理论依据和指导。具体包括 1. 神经细胞氧化应激介导mTOR抑制在帕金森病发生中作用分子机制； 2. 人源性B淋巴细胞刺激因子（hsBAFF）信号转导及免疫调节机制； 3. 环境污染物镉致神经细胞凋亡过程中MAPKs和Akt/mTOR通路信号转导网络及靶向调控机制； 4. 肿瘤细胞粘附、迁移过程中mTOR信号及其相关分子的信号转导及靶向药物抑制作用的分子机制； 5. 神经－内分泌－免疫网络中的多信号分子的相互关系及调控

近期论文

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1. Zhang R1, Zhang N1, Zhang H, Liu C, Dong X, Wang X, Zhu Y, Xu C, Liu L, Yang S, Huang S*, Chen L*. Celastrol prevents cadmium-induced neuronal cell death by blocking reactive oxygen species-mediated mammalian target of rapamycin pathway. Br J Pharmacol. 2017; 174: 82-100 (SCI收录, IF= 5.259). 2. Zhang R1, Zhu Y1, Dong X, Liu B, Zhang N, Wang X, Liu L, Xu C, Huang S*, Chen L*. Celastrol attenuates cadmium-induced neuronal apoptosis via inhibiting Ca2+-CaMKII-dependent Akt/mTOR pathway. J Cell Physiol. 2017; DOI: 10.1002/jcp.25703 (SCI收录, IF=4.155). 3. Xu C1, Wang X1, Gu C1, Zhang H, Zhang R, Dong X, Liu C, Hu X, Ji X, Huang S*, Chen L*. Celastrol ameliorates Cd-induced neuronal apoptosis by targeting NOX2-derived ROS-dependent PP5-JNK signaling pathway. J Neurochem. 2017; DOI:10.1111/jnc.13966 (SCI收录, IF= 3.842). 4. Zeng Q1, Qin S1, Zhang H, Liu B, Qin J, Wang X, Zhang R, Liu C, Dong X, Zhang S, Huang S*, Chen L*. Rapamycin attenuates BAFF-extended proliferation and survival via disruption of mTORC1/2 signaling in normal and neoplastic B-lymphoid cells. J Cell Physiol. 2017; DOI:10.1002/jcp.25913 (SCI收录, IF=4.155). 5. Xu C, Huang S, Chen L*. An insight of rapamycin against cadmium’s neurotoxicity. Oncotarget 2017; 8: 9013-9014 (SCI收录, IF= 5.008). 6. Liu C1, Ye Y1, Zhou Q, Zhang R, Zhang H, Liu W, Xu C, Liu L, Huang S*, Chen L*. Crosstalk between Ca2+ signaling and mitochondrial H2O2 is required for rotenone inhibition of mTOR signaling pathway leading to neuronal apoptosis. Oncotarget 2016; 7: 7534-7549 (SCI收录, IF= 5.008). 7. Xu C1, Wang X1, Zhu Y1, Dong X, Liu C, Zhang H, Liu L, Huang S*, Chen L*. Rapamycin ameliorates cadmium-induced activation of MAPK pathway and neuronal apoptosis via suppressing mitochondrial ROS-inactivated PP2A. Neuropharmacology 2016; 105: 270-284 (SCI收录, IF= 4.936). 8. Gui L1, Zeng Q1, Xu Z1, Zhang H, Qin S, Liu C, Xu C, Zhou Q, Zhang S, Huang S, Chen L*. IL-2, IL-4, IFN-γ or TNF- enhances BAFF-stimulated cell viability and survival by activating Erk1/2 and S6K1 pathways in neoplastic B-lymphoid cells. Cytokine 2016; 84: 37-46 (SCI收录, IF=2.94). 9. Xu C1, Zhang H1, Liu C, Zhu Y, Wang X, Gao W, Huang S*, Chen L*. Rapamycin inhibits Erk1/2-mediated neuronal apoptosis caused by cadmium. Oncotarget 2015; 6: 21452-21467 (SCI收录, IF= 6.359). 10. Chen L*, Xu B, Liu L, Liu C, Luo Y, Chen X, Barzegar M, Chung J, Huang S*. Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion. Oncotarget 2015; 6: 7136-7150 (SCI收录, IF=6.359). 11. Zeng Q, Zhang H, Qin J, Xu Z, Gui L, Liu B, Liu C, Xu C, Liu W, Zhang S, Huang S*, Chen L*. Rapamycin inhibits BAFF-stimulated cell proliferation and survival by suppressing mTOR-mediated PP2A-Erk1/2 signaling pathway in normal and neoplastic B-lymphoid cells. Cell Mol Life Sci. 2015; 72:4867–4884 (SCI收录, IF=5.808). 12. Xu C1, Liu C1, Liu L, Zhang R, Zhang H, Chen S, Luo Y, Chen L*, Huang S*. Rapamycin prevents cadmium-induced neuronal cell death via targeting both mTORC1 and mTORC2 pathways. Neuropharmacology 2015; 97: 35-45 (SCI收录, IF=5.106). 13. Chen L, Liu C, Huang S. A deut of mTORC1/2 for cell adhesion. Cell Cycle 2015; 14: 1131-1132 (SCI收录, IF=4.565). 14. Liu C1, Zhang R1, Sun C, Zhang H, Xu C, Liu W, Gao W, Huang S*, Chen L*. Resveratrol prevents cadmium activation of Erk1/2 and JNK pathways from neuronal cell death via protein phosphatases 2A and 5. J Neurochem. 2015; 135: 466-478 (SCI收录, IF=4.281). 15. Zhou Q1, Liu C1, Liu W1, Zhang H, Zhang R, Liu Jia, Zhang J, Xu C, Liu L, Huang S1, Chen L1,*. Rotenone induction of hydrogen peroxide inhibits mTOR-mediated S6K1 and 4E-BP1/eIF4E pathways, leading to neuronal apoptosis. Toxicol Sci. 2015; 143: 81-96 (SCI收录, IF=3.854). 16. Chen S1, Ren Q1, Zhang J, Ye Y, Zhang Z, Xu Y, Guo M, Ji H, Xu C, Gu C, Gao W, Huang S*, Chen L*. N-acetyl-L-cysteine protects against cadmium-induced neuronal apoptosis by inhibiting ROS-dependent activation of Akt/mTOR pathway in mouse brain. Neuropath Appl Neuro. 2014; 40: 759-777 (SCI收录, IF=4.97). 17. Xu Y1, Liu C1, Chen S, Ye Y, Guo M, Ren Q, Liu L, Zhang H, Xu C, Zhou Q, Huang S*, Chen L*. Activation of AMPK and inactivation of Akt results in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of Parkinson’s disease. Cell Signal. 2014; 26: 1680-1689 (SCI收录, IF=4.471). 18. Liang D1, Zeng Q1, Xu Z1, Zhang H, Gui L, Xu C, Chen S, Zhang S, Huang S*, Chen L*. BAFF activates Erk1/2 promoting cell proliferation and survival by Ca2+-CaMKII-dependent inhibition of PP2A in normal and neoplastic B-lymphoid cells. Biochem Pharmacol. 2014; 87: 332-343 (SCI收录, IF=4.65). 19. Chen S1, Gu C1, Xu C, Zhang J, Xu Y, Ren Q, Guo M, Huang S*, Chen L*. Celastrol prevents cadmium-induced neuronal cell death via targeting JNK and PTEN-Akt/mTOR network. J Neurochem. 2014; 128: 256-266 (SCI收录, IF=4.244). 20. Ke Z1, Liang D1, Zeng Q, Ren Q, Ma H, Gui L, Chen S, Guo M, Xu Y, Gao W, Zhang S, Chen L*. hsBAFF promotes proliferation and survival in cultured B lymphocytes via calcium signaling activation of mTOR pathway. Cytokine 2013; 62: 310-321 (SCI收录, IF=3.019).