个人简介
2015.1-至今 Wuxi Paribio Inc. Wuxi, China Founder, Executive board director, CSO
2010.2-2015.1 Wuxi BioHermes Inc. MaShan, Wuxi, China Founder, Executive board director, CSO
1999.11-2010.1 Wyeth Pharmaceuticals, (Acquired by Pfizer 2009) Princeton, NJ Sr. Research Scientist II (group leader)
1997.4-1999.10 Lexicon Pharmaceuticals, Woodlands, TXSr. Research Scientist I (PhD level, project leader)
1990.9-1997.3 UT MD Anderson Cancer Center, Houston, TXSr. Research Scientist (lab manager)
1983.8-1990.9 Shanghai institute of Biochemistry, Chinese Academy of ScienceSr. Research scientist
近期论文
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1. Chen Shuxian, Wang Xu, Ye Xianghui, Gong xiaohai, et al. Identification of human UMP/CMP kinase 1 as doxorubicin binding target using protein microarray. J Biomol Screen, 2017, 22: 1007-1015.
2. Fu Qianyun, Chen Zhen, Gong Xiaohai, et al. β-Catenin expression is regulated by an IRES-dependent mechanism and stimulated by paclitaxel in human ovarian cancer cells. Biochem and Bioph Res Co, 2015, 416: 21-27.
3. Qian Kai, Gong Xiaohai, Guan Bo, et al. Efficient expression of glucagon-like peptide-1 analogue with human serum albumin fusion protein in Pichia pastoris using the glyceraldehyde-3-phosphate dehydrogenase promoter. Biotechnol Bioproc E, 2015, 20: 694-700.
4. Qian Kai, Li Chengyuan, Gong Xiaohai, et al. Expression of a glucagon-like peptide-1 analogue, as a therapeutic agent for type II diabetes, with enhanced bioactivity and increased N-terminal homogeneity in Pichia pastoris. Biotechnol Lett, 2015, 37: 2229–2235.
5. Yang Xueli, Ndawula Jr Charles, Zhou Haiyan, Gong Xiaohai, Jin Jian. JF-305, a pancreatic cancer cell line is highly sensitive to the PARP inhibitor olaparib. Oncol lett, 2015, 9: 757-761.
6. Charles Ndawula Jr., Xueli Yang, Xiaohai Gong, Jian Jin CHK21100delC, I157T, IVS2 +IG > A, BRCA1 and BRCA2 Mutation Analysis in JF305: A Pancreatic Cancer Cell Line Journal of Biosciences and Medicines, 2014, 2, 58-67
7. Xueli Yang, Charles Ndawula, Haiyan Zhou, Xiaohai Gong, Jian Jin JF-305, a pancreatic cancer cell line is highly sensitive to the PARP inhibitor olaparib. Oncol Lett 2015 Feb 3;9(2):757-761.
8. Muhammad Imran Amirzada, Xin Ma, Xiaohai Gong, Yun Chen, Sajid Bashir, Jian Jin Recombinant human interleukin 24 reverses Adriamycin resistance in a human breast cancer cell line. Pharmacol Rep 2014 Oct 6;66(5):915-9.
9. Muhammad Imran Amirzada, Minglei Yu, Xiaohai Gong, Yun Chen, Ruiyu Zhu, Jianyong Lei, Jian Jin Cost-effective production of recombinant human interleukin 24 by lactose induction and a two-step denaturing and one-step refolding method. J Ind Microbiol Biotechnol 2014 Jan 31;41(1):135-42.
10. Haiyan Zhou, Jun Ma, Xueli Yang, Xiaohai Gong, Qiuping Li, Jian Jin Expression and purification of hPARP1 by baculovirus system. Sheng Wu Gong Cheng Xue Bao 2013 Jul;29(7):998-1005
11. Bo Guan, Jianyong Lei, Shuai Su, Fengxiang Chen, Zuoying Duan, Yun Chen, Xiaohai Gong, Huazhong Li, Jian Jin Absence of Yps7p, a putative glycosylphosphatidylinositol-linked aspartyl protease in Pichia pastoris, results in aberrant cell wall composition and increased osmotic stress resistance. FEMS Yeast Res 2012 Dec 25;12(8):969-79.
12. Robert L. Martone, Hua Zhou, Kevin Atchison, Thomas Comery, Jane Z. Xu, Xinyi Huang, Xioahai Gong, Mei Jin, Anthony Kreft, Boyd Harrison, Scott Mayer, Suzan Aschmies, Cathleen Gonzales, Margaret Zaleska, Davidc R. Riddell, Erik Wagner, Peimin Lu, Roy Sun, June Sonnenberg-Reines, Aram Oganesian, Karissa Adkins, Donna Huryn, Magid Abou-Gharbia, Ronald Magolda, Jonathan Bard, Jeffrey Paul, Glen Frick, Sangeeta Raje, S. Bradley Forlow, Carrie Balliet, Michael E. Burzynski, Peter Reinhart, Hong L. Wan, Menelas N. Pangalos, J. Steven Jacobsen* GSI-953 (Begacestat): A novel, selective thiophene sulfonamide inhibitor of APP γ-secretase for the treatment of Alzheimer’s disease Journal of Pharmacology and Experimental Therapeutics 2009, 331:598–608
13. Jie Zhang , Diana Chen , Xiaohai Gong , Huaiping Ling , Guoming Zhang , Andrew Wood , Julia Heinrich , Seongeun Cho Cyclic-AMP Response Element-Based Signaling Assays for Characterization of Trk Family Tyrosine Kinases Modulators. Neurosignals, 2006 Jul 6;15 (1): 26-39
14. Feng Liu, Xiaohai Gong, Guoming Zhang, Karen Marquis, Peter Reinhart and Terrance H. Andree The inhibition of glycogen synthase kinase 3b by a metabotropic glutamate receptor 5 mediated pathway confers neuroprotection to Aâ peptides. Journal of Neurochemistry, 2005, 95, 1363–1372
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