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个人简介

硕博,日本名古屋大学(1985-1990年) 博士后,哈佛大学(哈佛大学校长特邀博士后研究员,1990-1993年) 1993年5月—1998年2月研究员,项目经理,Novartis,USA 1998年2月—2000年1月化学业务总监,RepliGen Co., Needam, USA 2000年1月—2002年6月高级研究员,项目经理;Cytokinetics, Inc., USA 2002年6月—2008年6月高级研究员,项目经理;Roche/Genentech, Inc., USA 2008年6月—现在董事长兼总经理;AlphaBiopharmaceuticals,Inc., USA 2011年1月—现在江南大学太湖学者,特聘教授。工作期间, 在美国工作期间,有10个新药候选物进入欧美等国的临床研究; 取得临床批件40余张; 有4个新药上市(Tobi,Vismodegib,Kadcyla,TOBI Podhaler), 25年丰富且成功的新药物研发经验,拥有15项美国新药研发发明专利。 先后获批江苏省“双创”高端引进人才(2011年);无锡市领军人物(2012年)

研究领域

天然物化学,心血管疾病药物、抗感染药物、抗炎症药物,智能抗糖尿病药物,免疫性疾病以及抗肿瘤靶向药物

近期论文

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1. Determination of an isonicotinylhydrazide derivative, a novel positive inotropic compound, in mouse plasma by LC-MS/MS and its application to a pharmacokinetics studyJournal of Pharmaceutical and Biomedical Analysis (2019), 165, 12-17. 2. Design, synthesis, and biological evaluation of 2-(4-(methylsulfonyl)phenyl)pyridine derivatives as GPR119 agonistsChemical Biology & Drug Design (2019), 93(1), 67-74. 3. Synthesis and biological evaluation of novel 5,6-dihydropyrimido[4,5-f]quinazoline derivatives as potent CDK2 inhibitorsBioorganic & Medicinal Chemistry Letters (2018), 28(20), 3385-3390. 4. Alkylation method of nitrogen-containing hydrogen compound and its applicationFaming Zhuanli Shenqing (2018), CN 108503583 A 20180907, 5. Preparation of pyrazolo[1,5-a]pyrimidine compounds as antitumor agentsFaming Zhuanli Shenqing (2018), CN 108484613 A 20180904, 6. Pyrimido[4,5-f]quinazoline compounds as CDK inhibitors and their preparation, pharmaceutical compositions and use in the treatment of cancerFaming Zhuanli Shenqing (2018), CN 108484606 A 20180904, 7. Synthesis and SAR of 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivatives as potent and selective CDK4/6 inhibitorsEuropean Journal of Medicinal Chemistry (2018), 157, 935-945. 8. Pyrazolo[4,3-h]quinazoline compound and application thereofFaming Zhuanli Shenqing (2017), CN 107383019 A 20171124, 9. A polypeptide derivatization method and its application in maldi-tof-ms detection of medicine metabolites [Machine Translation].Faming Zhuanli Shenqing (2017), CN 107085032 A 20170822, 10. Transition-Metal-Free Trifluoromethylation of Aldehyde Derivatives with Sodium TrifluoromethanesulfinateJournal of Organic Chemistry (2017), 82(18), 9384-9399. 11. 1,2,5-Thiadiazole-2-oxide analogues as schistosomicides and their preparation, pharmaceutical compositions and use in the treatment of schistosomiasisFaming Zhuanli Shenqing (2017), CN 106632142 A 20170510, 12. Method for preparing statin bulk drug intermediate with improved Julia olefination reaction as key stepFaming Zhuanli Shenqing (2017), CN 106588763 A 20170426, 13. Synthesis method for chiral secondary allyl alcohol with hydroxy ortho position substituted with halogen atomFaming Zhuanli Shenqing (2017), CN 106588565 A 20170426, 14. Development and validation of pharmacophore of G protein-coupled receptor 40 agonistsJisuanji Yu Yingyong Huaxue (2017), 34(2), 157-162. 15. Gold-Oxazoline Complex-Catalyzed Cross-Dehydrogenative Coupling of Glycine Derivatives and AlkenesAdvanced Synthesis & Catalysis (2017), 359(5), 824-831. 16. Synthesis of aromatic amide derivatives and their biological evaluation against protein tyrosine phosphatase 1B and protein tyrosine phosphatase SHP2Youji Huaxue (2016), 36(9), 2142-2149. 17. Oxadiazole-2-oxides may have other functional targets, in addition to SjTGR, through which they cause mortality in Schistosoma japonicumParasites & Vectors (2016), 9, 26/1-26/12. 18. Lead-removing polysulfide ether composition and its application in health foodFaming Zhuanli Shenqing (2016), CN 105815781 A 20160803, 19. A sugar protein fluorescent probe molecules for continuous synthesis methodFaming Zhuanli Shenqing (2016), CN 105806820 A 20160727, 20. Gene expression profiling of H9c2 cells subjected to H2O2-induced apoptosis with/without AF-HF001Biological & Pharmaceutical Bulletin (2016), 39(2), 207-214.

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