马鑫 - 江南大学

个人简介

2005年7月获蚌埠医学院学士学位，2007年7月获浙江大学医学院硕士学位，2010年3月获香港中文大学医学院博士学位。后在香港中文大学生物医学学院从事博士后研究工作。现在江南大学医药学院工作。

研究领域

1，膜蛋白与心血管功能调节研究 2，膜蛋白与肿瘤多药耐药研究 3，药物靶标及诊断标志物的研究

近期论文

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1. Zhu Y(#), Pan Q(#), Meng H(#), Jiang Y(#), Mao A, Wang T, Hua D, Yao X, Jin J(*), Ma X (马鑫) (*). Enhancement of vascular endothelial growth factor release in long-term drug-treated breast cancer via transient receptor potential channel 5-Ca2+-hypoxia-inducible factor 1α pathway. Pharmacological Research. 2015 Jan 9; 93C :36-42 2. Wang T(#), Chen Z(#), Zhu Y(#), Pan Q, Liu Y, Qi X, Jin L, Jin J(*), Ma X (马鑫) (*), Hua D(*). Inhibition of Transient Receptor Potential Channel 5 Reverses 5-Fluorouracil Resistance in Human Colorectal Cancer Cells. Journal of Biological Chemistry. 2015 Jan 2;290(1):448-56 3. He DX(#), Gu XT(#), Jiang L, Jin J(*), Ma X (马鑫) (*). A Methylation-Based Regulatory Network for MicroRNA 320a in Chemoresistant Breast Cancer. Molecular Pharmacology. 2014 Nov;86(5):536-47 4. Zhang FF(#), Zhu YF(#), Zhao QN(#), Yang DT, Dong YP, Jiang L, Xing WX, Li XY, Xing H, Shi M, Chen Y, Bruce IC, Jin J(*), Ma X (马鑫) (*). Microvesicles mediate transfer of P-glycoprotein to paclitaxel-sensitive A2780 human ovarian cancer cells, conferring paclitaxel-resistance. European Journal of Pharmacology. 2014 Sep 5;738:83-90 5. Jiang L(#), He D(#), Yang D(#), Chen Z, Pan Q, Mao A, Cai Y, Li X, Xing H, Shi M, Chen Y, Bruce IC, Wang T, Jin L, Qi X, Hua D, Jin J(*), Ma X (马鑫) (*). MiR-489 regulates chemoresistance in breast cancer via epithelial mesenchymal transition pathway. FEBS Letter. 2014 May 29;588(11):2009-15 6. Ma X (马鑫) (#),(*), Chen Z(#), Hua D(#), He D(#), Wang L, Zhang P, Wang J, Cai Y, Gao C, Zhang X, Zhang F, Wang T, Hong T, Jin L, Qi X, Chen S, Gu X, Yang D, Pan Q, Zhu Y, Chen Y, Chen D, Jiang L, Han X, Zhang Y, Jin J (*), Yao X. Essential role for TrpC5-containing extracellular vesicles in breast cancer with chemotherapeutic resistance. Proceedings of the National Academy of Sciences USA . 2014 Apr 29;111(17):6389-94 7. Ma X (马鑫) (#), Du J(#), Zhang P, Deng J, Liu J, Lam F, Huang Y, Yao X (*). Functional role of TRPV4-KCa2.3 coupling in vascular endothelial cells in normal and streptozotocin induced diabetic rats. Hypertension. 2013 Jul;62(1):134-9 8. Ma X (马鑫) (#), Cai Y(#), He D(#), Zou C, Zhang P, Lo CY, Xu Z, Chan L, Yu S, Chen Y, Zhu R, Lei J, Jin J (*), Yao X (*). A transient receptor potential channel TRPC5 is essential for p-glycoprotein induction in drug-resistant cancer cells. Proceedings of the National Academy of Sciences USA . 2012 Oct 2;109(40):16282-7 9. Ma X (马鑫), Cao J , Luo J, Nilius B, Huang Y, Ambudkar IS, Yao X (*). Depletion of intracellular Ca2+ stores stimulates the translocation of TRPV4-C1 heteromeric channels to the plasma membrane. Arteriosclerosis, Thrombosis and Vascular Biology. 2010 Nov;30(11):2249-55 10. Ma X (马鑫), Qiu S, Luo J, Ma Y, Ngai CY, Shen B, Wong CO, Huang Y, Yao X (*). Functional role of TRPV4-C1 complex in flow-induced Ca2+ influx. Arteriosclerosis Thrombosis, and Vascular Biology. 2010 Apr;30(4):851-8