金坚 - 江南大学

个人简介

1978.9～1983.7苏州医学院临床医学专业，获医学学士学位。1983.08～1991.08卫生部核医学重点实验室，实习研究员，助理研究员，副研究员。1991.9～1993.6 苏州医学院生物化学与分子生物学专业，医学硕士。1993.9～1996.7 苏州医学院药理学专业，医学博士。1996.08～1998.07 法国健康与卫生研究院 INSERM U353研究所，研究员。1998.08～1999.07 核医学国家重点实验室，研究员，硕士生导师。1999.08～2001.10 法国国家科研中心CNRS巴黎 Gustave Rossuy 肿瘤研究所，研究员。2001年11月至今，任江南大学生物工程学院、医药学院、药学院制药工程系教授、博士生导师、药物设计与分子药理学研究室主任。

研究领域

长效重组药物设计、心脑血管和糖尿病药物研究、肿瘤药物抵抗研究

近期论文

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[1] Transient receptor potential channel TRPC5 is essential for P-glycoprotein induction in drug-resistant cancer cells.Proc Natl Acad Sci USA 2012, 109:16282-7 [2] Essential role for TrpC5-containing extracellular vesicles in breast cancer with chemotherapeutic resistance.Proc Natl Acad Sci USA 2014, 111 : 6389-94 [3] Inhibition of Transient Receptor Potential Channel 5 Reverses 5-Fluorouracil Resistance in Human Colorectal Cancer Cells.J Biol Chem 2015, 290: 448-56 [4] Functional Role of TRPV4-KCa2.3 Signaling in Vascular Endothelial Cells in Normal and Streptozotocin-Induced Diabetic Rats.Hypertension 2013, 62: 134-9 [5] Enhanced α-zearalenol hydrolyzing activity of a mycoestrogen-detoxifying lactonase by structure-based engineering.ACS Catalysis 2016,6:7657-63 [6] Chemotherapy enhances tumor vascularization via Notch signaling-mediated formation of tumor-derived endothelium in breast cancer.Biochem Pharm2016,118:18-30 [7] ERα mediates alcohol-induced deregulation of Pol III genes in breast cancer cells.Carcinogenesis 2013, 34: 28-37 [8] Apigenin, a plant-derived flavone, activates transient receptor potential vanilloid 4 cation channel.Brit J Pharmacol 2012, 166: 349–58 [9] A Methylation-based Regulatory Network for microRNA 320a in Chemoresistant Breast Cancer.Mol Pharmacol 2014, 86:536-47 [10] Methylation-regulated miR-149 modulates chemoresistance by targeting GlcNAc N-deacetylase/ N-sulfotransferase-1 in human breast cancer.FEBS J 2014, 281: 4718-30 [11] MiR-489 regulates chemoresistance in breast cancer via epithelial mesenchymal transition pathway.FEBS Lett 2014, 588: 2009-15 [12] Induction of acquired drug resistance in endothelial cells and its involvement in anticancer therapy.J Hematol Oncol 2013, 6:49-55 [13] Enhancement of vascular endothelial growth factor release in long-term drug-treated breast cancer via transient receptor potential channel 5-Ca2+-hypoxia-inducible factor 1α pathway.Pharm Res-Dordr 2015，93：36-42 [14] Functional and structural analyses of a 1,4-β-endoglucanase from Ganoderma lucidum.Enzyme Microb Tech 2016, 86: 67-74 [15] Electrostatic potentials of camptothecin and its analogues.Theor Chem ACC 2014,133:1541-3 [16] Crystallization and preliminary X-ray diffraction analysis of an endo-1,4-ß-D-glucanase from Aspergillus aculeatus F-50.Acta Cryst.2015，F71, 397-400 [17] Luteolin inhibits pyrogallol-induced apoptosis through the extracellular signal-regulated kinases signaling pathway.FEBS J 2012, 279: 1834-43 [18] Vasonatrin peptide stimulates both of the natriuretic peptide receptors, NPRA and NPRB.Biochem Bioph Res Co 2014, 466：1276–80 [19] Comparative study of the effect of rivaroxaban and fondaparinux on monocyte's coagulant activity and cytokine release.Experimental Hematology & Oncology 2014, 3:30-41 [20]A transcription/translation-based gene signature predicts resistance to chemotherapy in breast cancer.J Pharmaceut Biomed 2015, 102: 500-8