个人简介
2001.9-2005.6 江南大学,生物工程专业,工科学士;
2005.9-2007.6 江南大学,生物工程学院, 发酵工程专业,工学硕士,导师:陈坚,教授;
2007.8-2011.5 美国弗吉尼亚联邦大学(Virginia Commonwealth University),化学与生命科学工程专业(Chemical and Life Science Engineering),工学博士导师:Dr. Stephen S. Fong, 教授;
2011.5- 2013.6 博士后研究员(Postdoctoral Research Associate),Thayer工学院(Thayer School ofEngineering),美国达特茅斯学院(Dartmouth College)。
2013.8-2014.12 助理教授(Assistant Professor),生物与农业工程系(Department of Biological andAgricultural Engineering), 美国堪萨斯州立大学(Kansas State University);
2015.1-现在江南大学粮食发酵工艺与技术国家工程实验室,代谢工程团队负责人。
研究领域
长期从事发酵工程,代谢工程,合成生物学,工业微生物的研究
近期论文
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1.Mei Zhao, Guohui Li, Yu Deng*, Engineering Escherichia coli for glutarate production as the C5platform backbone, Applied and Environmental Microbiology, 2018, 84:e00814-18. (IF 3.633).
2.Na Chen, Jingya Wang, Yunying Zhao and Yu Deng*. Metabolic engineering of Saccharomycescerevisiae for efficient production of glucaric acid at high titer, Microbial Cell factories, 2018, 17:67 (IF=3.831)
3.Mei Zhao, Dixuan Huang, Xiaojuan Zhang, Mattheos A.G. Koffas, Jingwen Zhou and Yu Deng*.Metabolic engineering of Escherichia coli for producing adipic acid through the reverse adipate-degradation pathway, Metabolic Engineering, 2018, 47:254-262. (IF =7.674)
4.Yu Deng*, Ning Ma, Kangjia Zhu, Xuetuan Wei*, Yunying Zhao, Balancing the carbon fluxdistributions between the TCA cycle and glyoxylate shunt to produce glycolate at high yield and titer inEscherichia coli, Metabolic Engineering, 2018, 46: 28-34. (IF =7.674)
5.Zongsheng Zou, Yunying Zhao, Tingzhou Zhang, Jiaxing Xu, Aiyong He, and Yu Deng*. EfficientIsolation and Characterization of a Cellulase Hyperproducing Mutant Strain of Trichoderma reesei,Journal of Microbiology and Biotechnology, 2018 9; 28(9): 1473~1481. (IF =1.65)
6.Yu Deng*, Xi Zhang, Xiaojuan Zhang, Recent advances in genetic modification systems forActinobacteria, Applied Microbiology and Biotechnology, 2017, 101(6):2217-2226(IF=3.340).
7.Yu Deng*, Jia Lin, Yin Mao & Xiaojuan Zhang,Systematic analysis of an evolved Thermobifidafusca muC producing malic acid on organic and inorganic nitrogen sources, Scientific Reports, 2016, 6(IF=4.122).
8.Yu Deng, Mingxue Sun , Sha Xu and Jingwen Zhou, Enhanced (S)-linalool production by fusionexpression of farnesyl diphosphate synthase and linalool synthase in Saccharomyces cerevisiae, Journalof Applied Microbiology, 2016, 121, 187-195 (IF=2.160).
9.Yu Deng*, Yin Mao and Xiaojuan Zhang, Metabolic Engineering of a laboratory-evolvedThermobifida fusca muC strain for malic acid production on cellulose and minimal treatedlignocellulosic biomass. Biotechnology Progress, 2016, 32:14-20. (IF= 1.947)
10.Yu Deng*, Yin Mao and Xiaojuan Zhang, Driving carbon flux through exogenous butyryl-CoA:Acetate CoA-transferase to produce butyric acid at high titer in Thermobifida fusca. Journal ofBiotechnology, 2015, 216:151–157. (IF= 2.533)
11.Yu Deng*, Li Zhou Ma and Yin Mao, Biological production of adipic acid from renewable substrates:current and future methods. Biochemical Engineering Journal, 2016, 105:16–26. (IF=3.226)
12.Yu Deng*, Yin Mao and Xiaojuan Zhang, Metabolic Engineering of E. coli for Efficient Productionof Glycolic Acid from Glucose, Biochemical Engineering Journal, 2015, 103: 256-262. (IF=3.226)
13.Yu Deng*, Adam Fisher and Stephen Fong, Systematic analysis of intracellular mechanisms ofpropanol production in the engineered Thermobifida fusca B6 strain. Applied Microbiology andBiotechnology, 2015, 99: 8089-8100. (IF=3.340)
14.Yu Deng* and Yin Mao, Production of adipic acid by the native-occurring pathway in Thermobifidafusca B6, Journal of Applied Microbiology, 2015, 119:1057–1063. (IF =2.160)
15.Yu Deng* and Xiaojuan Zhang, DtxR, an iron-dependent transcriptional repressor that regulates theexpression of siderophore gene clusters in Thermobifida fusca, FEMS Microbiology Letters, 2015, 362:1–6. (IF=1.735)
16.Yu Deng, Daniel G. Olson, Jilai Zhou, Christopher D. Herring, Arthur J. Shaw, Lee R. Lynd.Redirecting carbon flux through exogenous pyruvate kinase to achieve high ethanol yields in Clostridiumthermocellum. Metabolic Engineering, 2013,15:151-158. (IF=7.674)
17.Yu Deng, Stephen S. Fong. Laboratory evolution and multi-platform genome re-sequencing of thecellulolytic actinobacterium Thermobifida fusca. Journal of Biological Chemistry, 2011, 286: 39958-39966. (IF=4.010)
18.Yu Deng, Stephen S. Fong. Metabolic engineering of Thermobifida fusca for direct aerobicbioconversion of untreated lignocellulosic biomass to 1-propanol. Metabolic Engineering, 2011,13: 570-577. (IF=7.674)
19.Yu Deng and Stephen Fong, Development and application of a PCR-targeted gene disruption methodfor studying CelR function in Thermobifida fusca. Applied and Environmental Microbiology, 2010, 76:2098-2106. (IF= 3.633)
20.Yu Deng and Stephen Fong, Influence of culture aeration on the cellulase activity of Thermobifidafusca. Applied microbiology and biotechnology, 85, 965-974. (IF=3.334)