刘龙 - 江南大学 - 生物工程学院

个人简介

工作经历 2014.10-至今: 江南大学生物工程学院，教授、博士生导师 2012.3-2013.3: 美国佐治亚理工学院，博士后 2010.8-2014.9: 江南大学生物工程学院，副教授 2009.5-2010.7: 江南大学生物工程学院，讲师

研究领域

从事枯草芽孢杆菌动态代谢调控元件挖掘、动态代谢调控方法理性设计与级联动态代谢调控技术的开发，依托上述方法与技术构建高效微生物细胞工厂生产重要功能营养品(乙酰氨基葡萄糖、母乳寡糖、几丁质寡糖、低聚乳果糖、熊果苷、糖基维C、系列脂溶性维生素、克拉酸等)的研究，通过代谢途径理性设计、代谢网络模块调控和调控网络动态重构等实现底物的定向转化和产物的高效合成。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1、Liu Long, Chen Jian. 《Systemsand Synthetic Biotechnology for the Production of Nutraceuticals》(Springer-Nature出版社)，2019年。 2、Deng Jieying, Chen Chunmei, Gu Yang, Lv Xueqin, Liu Yenfeng, Li Jianghua, Ledesma-Amaro Rodrigo, Du Guocheng, Liu Long*. Creating an in vivo bifunctional gene expression circuit through an aptamer-based regulatory mechanism for dynamic metabolic engineering in Bacillus subtilis. Metabolic Engineering. 2019. 55: 179-190. 3、Gu Yang, Liu Yanfeng, Li Jianghua, Du Guocheng, Ledesma-AmaroRodrigo, Liu Long*. Synthetic redesign of central carbon and redox metabolism for high yield production of N-acetylglucosamine in Bacillussubtilis. Metabolic Engineering. 2019. 51: 59-69. 4、Wu Yaokang, Chen Taichi, Liu Yenfeng, Lv Xueqin, Li Jianghua, Du Guocheng, Ledesma-AmaroRodrigo, Liu Long*. CRISPRi allows optimal temporal control of N-acetylglucosamine bioproduction by a dynamic coordination of glucose and xylose metabolism in Bacillus subtilis.Metabolic Engineering. 2018. 49: 232-241. 5、Gu Yang, Xu Xianhao, Wu Yaokang, Niu Tengfei, Liu Yanfeng, Li Jianghua, Du Guocheng, LiuLong*. Advances and prospects of Bacillus subtiliscellular factories: from rational design to industrial applications. Metabolic Engineering. 2018. 50: 109-121 6、Cui Shixiu, Lv Xueqin, Wu Yaokang, Li Jianghua, Du Guocheng, Ledesma-Amaro Rodrigo, Liu Long*. Engineeringa bifunctional Phr60-Rap60-Spo0A quorum-sensing molecular switch for dynamic fine-tuning of menaquinone-7 synthesis in Bacillus subtilis. ACS Synthetic Biology. 2019. 8: 1826-1837.(cover paper) 7、Niu Tengfei, Liu Yanfeng, Li Jianghua, Koffas Matheson, Du Guocheng, Alper Hal S., Liu Long*. Engineering a glucosamine-6-phosphate responsive glmS ribozyme switch enables dynamic control of metabolic flux in Bacillus subtilisfor overproduction of N-acetylglucosamine. ACS Synthetic Biology. 2018.7:2423-2435(cover paper) 8、Liu Jingjing, Li Jianghua, Liu Yanfeng, Shin Hyun-dong, Ledesma-AmaroRodrigo, Du Guocheng, Chen Jian, Liu Long*. Synergistic rewiring of carbon metabolism and redox metabolism in cytoplasm and mitochondria of Aspergillus oryzaefor increased L-malate production. ACS Synthetic Biology.2018. 7: 2139-2147. 9、Deng Chen, Li Jianghua, Liu Yanfeng, Du Guocheng, Ledesma-Amaro Rodrigo, Liu Long*. Synthetic repetitiveextragenic palindromic (REP) sequence as an efficient mRNA stabilizer for protein production and metabolic engineering in prokaryotic cells. Biotechnology and Bioengineering.2019. 116: 5-18(Cover paper) 10、Yuan Haibo, Liu Yanfeng, Li Jianghua, Shin Hyun-dong, Du Guocheng, Shi Zhongping, Chen Jian, Liu Long*. Combinatorial synthetic pathway fine-tuning and comparative transcriptomics for metabolic engineering of Raoultella ornithinolyticaBF60 to efficiently synthesize 2,5-furandicarboxylic acid. Biotechnology and Bioengineering.2018. 115: 2148-2155(cover paper) 11、Guan Ningzi, Du Bin, Li Jianghua, Shin Hyun-dong, Chen Rachel R., Du Guocheng, Chen Jian, Liu Long*. Comparative genomics and transcriptomics analysis-guided metabolic engineering of Propionibacterium acidipropionicifor improved propionic acid production. Biotechnology and Bioengineering.2018. 115: 483-494. 12、Hou Ying, Hossain Gazi Sakir, Li Jianghua, Shin Hyun-dong, Du Guocheng, Chen Jian, Liu Long*. Metabolic engineering of cofactor flavin adenine dinucleotide (FAD) synthesis and regeneration in Escherichia coli for production of α-keto acids. Biotechnology and Bioengineering.2017. 114: 1928-1936 13、Liu Yanfeng, Li Jianghua, Du Guocheng, Chen Jian, Liu Long*. Metabolic engineering of Bacillus subtilisfueled by systems biology: recent advances and future directions. Biotechnology Advances.2017. 35: 20-30 14、Liu Yanfeng, Link Hannes, Liu Long*, Du Guocheng, Chen Jian*, Sauer Uwe. A novel dynamic pathway analysis approachreveals a limiting futile cycle inN-acetylglucosamineoverproducing Bacillus subtilis. Nature Communications. 2016. 7:11933 15、Guan Ningzi, Li Jianghua, Shin Hyun-dong, Du Guocheng, Chen Jian, Liu Long*. Metabolic engineering of acid resistance elements to improve acid resistance and propionic acid production of Propionibacterium jensenii. Biotechnology andBioengineering.2016.113: 1294-1304.