吴志猛 - 江南大学 - 生物工程学院

个人简介

1995-1999 安徽师范大学，化学教育专业，学士 1999-2002 延边大学，化学专业，硕士 2002-2005 浙江大学，有机化学，博士 2005-2008 美国NIH Karmanos Cancer Institute，博士后 2008-2011 美国Wayne state University，博士后 2011-2013 新西兰皇家科学院工业研究院，研究科学家 2013-至今江南大学，生物工程学院教授、博导

研究领域

长期从事糖化学与药物化学交叉的研究工作，致力于复杂寡糖、糖肽、糖脂及其它糖缀合物的合成新方法学研究 (包括化学合成和生物合成)，并应用于化学生物学、药物化学、糖生物学、抗肿瘤和细菌疫苗糖免疫学等研究；另外课题组还致力于纳米抗体用于肿瘤免疫治疗、抗体偶联药物研发等

近期论文

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C. Li, S.J. Dai, A.J. Cao, Z.F. Zhou, Z.M.Wu*, Design and synthesis of rhamnose-modified exenatide conjugate by sortase A-mediated ligation, J. Carbohyd. Chem., 2019, 38, 167-178. H.F. Hong, Z.F Zhou, K. Zhou, S. Z. Liu, Z. G. Guo*, Z.M.Wu*, Site-specific C-terminal dinitrophenylation to reconstitute the antibody Fc functions for nanobodies, Chem. Sci., 2019, 10, 9331-9338. J.J. Liu, X.Z. Cheng, X.B. Tian, D.L. Guan, J. Ao, Z.M.Wu*, W. Huang*, Z.P. Le*, Design and synthesis of novel dual-cyclic RGD peptides for alpha(v)beta(3) integrin targeting, Bioorg. Med. Chem. Lett., 2019, 39, 896-900. H.F. Hong, X.R. Zhao, Z.M.Wu*, A two-stage glycine supplementation strategy enhances the extracellular expression of sortase A in Escherichia coil, Process Biochem., 2019, 76, 11-17. Z.F. Zhou, H. Lin, C. Li, Z.M.Wu*, Recent progress of fully synthetic carbohydrate-based vaccine using TLR agonist as build-in adjuvant, Chinese Chem. Lett., 2018, 29, 19-26. M. Yang, H.F. Hong, S.Z. Liu, X.R. Zhao, Z.M.Wu*, Immobilization of Staphylococcus aureus Sortase A on Chitosan Particles and Its Applications in Peptide-to-Peptide Ligation and Peptide Cyclization, Molecules, 2018, 23, 192. X.Z. Cheng, H.F. Hong, Z.F. Zhou, Z.M.Wu*, Enzymatic On-Resin Peptide Cleavage and in Situ Cyclization One-Pot Strategy for the Synthesis of Cyclopeptide and Cyclotide, J. Org. Chem., 2018,83, 14078-14083. X. Cheng, T. Zhu, H, Hong, Z. Zhou, Z.M.Wu*, Sortase A-mediated on-resin peptide cleavage and in situ ligation: an efficient one-pot strategy for the synthesis of functional peptides and proteins Org. Chem. Front. 2017, 4, 2058-2062. X. Zhao, H. Hong, X, Cheng, S, Liu, T, Deng, Z, Guo, Z.M.Wu*, One-step purification and immobilization of extracellularly expressed sortase A by magnetic particles to develop a robust and recyclable biocatalyst, Sci. Rep. 2017, 7, 6561. Z.M.Wu*, X. Cheng , H. Hong , X. Zhao , Z. Zhou, New potent and selective αvβ3 integrin ligands: macrocyclic peptides containing RGD motif synthesized by sortase A-mediated ligation, Bioorg. Med. Chem. Lett., 2017, 27, 1911–1913.