聂尧 - 江南大学 - 生物工程学院

个人简介

1996-2000 无锡轻工大学，生物工程专业，工科学士 2000-2003 江南大学，发酵工程专业，工学硕士 2003-2007 江南大学，发酵工程专业，工学博士 2007-2008 江南大学，生物工程学院，讲师 2008-2012 江南大学，生物工程学院，副教授 2012-至今江南大学，生物工程学院，教授其中 2008-2009 美国罗格斯大学，高级生物技术与医学中心，博士后

研究领域

长期从事微生物分子酶学与催化工程的理论及应用等方面的研究

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1、Yao Nie, Shanshan Wang, Yan Xu, Shengan Luo, Yi-Lei Zhao, Rong Xiao, GaetanoMontelione, John F Hunt, Thomas Szyperski. Enzyme engineering based on X-ray structures andkinetic profiling of substrate libraries: alcohol dehydrogenases for stereospecific synthesis of abroad range of chiral alcohols, ACS Catalysis, 2018, 8: 5145-5152. 2、Shanshan Wang, Yao Nie*, Yan Xu, Rongzhen Zhang, Tzu-Ping Ko, Chun-Hsiang Huang,Hsiu-Chien Chan, Rey-Ting Guo, Rong Xiao. Unconserved substrate-binding sites direct thestereoselectivity of medium-chain alcohol dehydrogenase. Chemical Communications, 2014,50(58): 7770-7772. 3、Xinye Wang, Yao Nie*, Xiaoqing Mu, Yan Xu, Rong Xiao. Disorder prediction-basedconstruct optimization improves activity and catalytic efficiency of Bacillus naganoensispullulanase. Scientific Reports, 2016, 6: 24574. 4、Yao Nie, Rong Xiao, Yan Xu, Gaetano T. Montelione. Novel anti-Prelog stereospecificcarbonyl reductases from Candida parapsilosis for asymmetric reduction of prochiral ketones.Organic and Biomolecular Chemistry, 2011, 9(11): 4070-4078. 5、Yao Nie, Yan Xu, Qing Mu Xiao, Yan Wang Hai, Ming Yang, Rong Xiao. Purification,characterization, gene cloning, and expression of a novel alcohol dehydrogenase with anti-prelogstereospecificity from Candida parapsilosis. Applied and Environmental Microbiology, 2007,73(11): 3759-3764. 6、 Qingsen Hu, Yan Xu, Yao Nie. Enhancement of Candida parapsilosis catalyzingderacemization of (R,S)-1-phenyl-1,2-ethanediol to its (S)-enantiomer by a highly productive "two-in-one" resin-based in situ product removal strategy. Bioresource Technology, 2010, 101(21): 8461-8463. 7、 Yao Nie, Yan Xu, Xiaoqing Mu. Highly enantioselective conversion of racemic 1-phenyl-1,2-ethanediol by stereoinversion involving a novel cofactor-dependent oxidoreduction system ofCandida parapsilosis CCTCC M203011. Organic Process Research & Development, 2004, 8(2):246-251. 8、Xumin Gong, Yao Nie, Yan Xu, Rong Xiao, Gaetano T. Montelione. Influence of site-directedmutagenesis in coenzyme-binding domain of carbonyl reductase on its catalytic performance forasymmetric reduction. Chinese Journal of Catalysis, 2012, 33(2): 330-335