当前位置: X-MOL首页全球导师 国内导师 › 季维智

个人简介

现任昆明理工大学灵长类转化医学研究中心主任,生物医学动物模型国家地方联合工程研究中心主任,云南省灵长类生物医学动物重点实验室理事长。“国家干细胞研究指导协调委员会”专家,“国家重大科学研究计划生殖与发育专家组”成员(2006-2014),“国家实验动物研究委员会”专家组成员和973项目首席科学家。1982年毕业于云南大学生物系,1995-1997年任美国威斯康星大学动物医学与生物化学系客座教授,1996-2005年任中科院昆明动物研究所所长。

研究领域

现从事灵长类生殖发育生物学和干细胞的研究,其所领导的研究团队在猕猴干细胞和转基因灵长类动物方面获得国际一流的研究成果,使我国在非人灵长类靶向基因修饰的研究,居于世界领先水平。

近期论文

查看导师最新文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1.Niu Y, Shen B, Cui Y, Chen Y, Wang J, Wang L, Kang Y, Zhao X, Si W, Li W, Xiang AP, Zhou J, Guo X, Bi Y, Si C, Hu B, Dong G, Wang H, Zhou Z, Li T, Tan T, Pu X, Wang F, Ji S, Zhou Q, Huang X*, Ji W*, Sha J*. Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos. Cell, Volume 156, Issue 4, 836-843, 30 January 2014 2.Liu H, Chen Y, Niu Y, Zhang K, Kang Y, Ge W, Liu X, Zhao E, Wang C, Lin S, Jing B, Si C, Lin Q, Chen X, Lin H, Pu X, Wang Y, Qin B, Wang F, Wang H, Si W, Zhou J, Tan T, Li T, Ji S, Xue Z, Luo Y, Cheng L, Zhou Q, Li S*, Sun YE*, Ji W*. TALEN-Mediated Gene Mutagenesis in Rhesus and Cynomolgus Monkeys. Cell Stem Cell, Volume 14, Issue 3, 323-328, 13 February 2014 3.Tan T, Lu B, Zhang J, Niu YY, Si W, Wei Q, Ji WZ 2013 Notch1 Signaling Antagonizes Transforming Growth Factor-β Pathway and Induces Apoptosis in Rabbit Trophoblast Stem Cells. Stem Cells and Development.doi:1089/scd.2013.0280 4.Chen Y, Niu Y, Ji W. 2012 Transgenic nonhuman primate models for human diseases: approaches and contributing factors. J Genet Genomics. 39(6):247-51. 5.Chen Y, Niu Y, Yang S, He X, Ji S, Si W, Tang X, Xie Y, Wang H, Lv Y, Zhou Q and Ji W. 2012 The Available Time Window for Embryo Transfer in the Rhesus Monkey (Macaca mulatta). American Journal of Primatology. 74 (2):165–173 6.Chen Y, Wang Z, Xie Y, Guo X, Tang X, Wang S, Yang S, Chen K, Niu Y, Ji W.2012Folic acid deficiency inhibits neural rosette formation and neuronal differentiation from rhesus monkey embryonic stem cells. J Neurosci Res. 90(7):1382-91 7.Tn T, Tang X, Zhang J, Niu Y, Chen H, Li B, Wei Q, Ji W. 2011 Generation of trophoblast stem cells from rabbit embryonic stem cells with BMP4. Plos One Volume 6 | Issue 2 | e17124. 8.Yang S, Ping S, Si W, He X, Wang X, Lu Y, Ji S, Niu Y, Ji W. 2011 Optimization of ethylene glycol concentrations, freezing rates and holding times in liquid nitrogen vapor for cryopreservation of rhesus macaque (Macaca mulatta) sperm. J Vet Med Sci. 73(6):717-23. 9.Yang S, Ping S, Ji S, Lu Y, Niu Y, Wang H, Ji W, Si W. 2011 The positive effects of seminal plasma during the freezing process on cryosurvival of sperm with poor freezability in the rhesus macaque (Macaca mulatta). J Reprod Dev. 57(6):737-43. 10.Niu Y, Yu Y, Bernat A, Yang S, He X, Guo X, Chen D, Chen Y, Ji S, Si W, Li Y, Tan T, Wei Q, Wang H, Shi L, Guan J, Zhu X, Afanassieff M, Savatier P, Zhang K, Zhou Q, Ji W. 2010 Transgenic rhesus monkeys produced by gene transfer into early cleavage stage embryos using a simian immunodeficiency virus-based vector. Proc Natl Acad Sci U S A. 12:107(41):17663-7. 11.Wang Y, Hai T, Liu Z, Zhou S, Lv Z, Ding C, Liu L, Niu Y, Zhao X, Tong M, Wang L, Jouneau A, Zhang X, Ji W, Zhou Q. 2010 HSPC117 deficiency in clonedembryos causes placental abnormality and fetal death. Biochem Biophys Res Commun. 397(3):407-12. 12.Chen HW, Wei Q, Zhang J, Xu CK, Tan T, Ji WZ 2010 Netrin-1 signaling mediates O-induced glial precursor migration and accumulation. Cell Research advance online publication 19 January 2010; doi: 10.1038/cr.2010.7 13.Chen X, Li T Li X, Xie Y, Guo X, Ji S, Niu Y, Yu Y, Ding C, Yao R, Yang S, Ji W, Zhou Q 2009 Neural progenitors derived from monkey embryonic stem cells in a simple monoculture system. Reproductive BioMedicine 19: 426-433. 14.Ren G, Su J, Zhang L, Zhao X, Ling W, L'huillie A, Zhang J, Lu Y, Roberts AI, Ji W, Zhang H, Rabson AB, Shi Y. 2009 Species variation in the mechanisms of mesenchymal stem cell-mediated immunosuppression. Stem Cells. 27(8):1954-62. 15.Jin LF, Ji SH, Shen Y, Tang XH, Guo XY, Lu YQ, Chen HW, Deng HK, Yan XY, Zhou Q, Ji WZ. 2009 Isolation and characterization of liver epithelial progenitor cells from normal adult rhesus monkeys (Macaca mulatta). Cell Research 19:268-270. 16.Yang S, He X, Niu Y, Hildebrandt TB, Jewgenow K, Goeritz F, Tang X, Chang Y, Zhou Q, Ji W. 2009 Ovarian response to gonadotropin stimulation in juvenile rhesus monkeys. Theriogenology 72: 243-50.

推荐链接
down
wechat
bug