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个人简介

司维,博士,教授,云南省中青年学术技术带头人。1997年毕业于云南大学生物系,2004年获中国科学院研究生院理学博士。2009-2014年任中科院昆明动物研究所副研究员。获2017年云南省自然科学一等奖,2015年云南省科学技术进步三等奖,2012年云南省自然科学三等奖。 1993年-1997年,云南大学生物系,生物学专业,获生物学学士学位 1997年-2004年,中科院昆明动物研究所,动物学专业,生殖生物学研究方向获动物学博士学位 2004年2月 – 2005年2月,中科院昆明动物研究所,实习研究员 2005年2月 –2007年11月,美国University of Missouri-Columbia,博士后 2007年11月-2008年11月,美国 Medical College of Georgia,博士后 2008年12月-2014年12月,中科院昆明动物研究所,副研究员 2014年12月至今,昆明理工大学灵长类转化医学研究院,教授

研究领域

主要从事人类疾病(神经退行性疾病,代谢疾病,关节炎等)的灵长类动物模型建立、细胞治疗和基因治疗的机制、有效性和安全性评价的临床前和临床研究;开展灵长类种质资源和干细胞细胞超低温,研究冷冻损伤机制和提高保存效率的对策;灵长类发育过程中细胞分化的基因组表达和甲基化调控的研究。

近期论文

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1. Wang H#, Yan Y#, Yi X#, Duan Y, Wang J, Li S, Luo L, Huang T, Inglis B, Li X, Ji W, Tan T*, Si W*. Histopathological features and composition of gut microbiota in rhesus monkey of alcoholic liver disease. Frontier in Microbiology. 2019, 10: 165. 2. Wang Y#, Wang H#, Zhang Y#, Du Z#, Si W#, Fan S, Qin D, Wang M, Duan Y, Li L, Jiao Y, Li Y, Wang Q, Shi Q, Wu X*, Xie W*. Reprogramming of Meiotic Chromatin Architecture during Spermatogenesis. Molecular Cell. 2019, 73:547-561. 3. Yan L#, Jiang B#, Niu Y#, Wang H, Li E, Yan Y, Sun H, Duan Y, Chang S, Chen G, Ji W*, Xu RH*, Si W*. Intrathecal delivery of human ESC-derived mesenchymal stem cell spheres promotes recovery of a primate multiple sclerosis model. Cell Death Discov. 2018, 5:28. 4. Jiao Y, Zhao H, Chen G, Sang X, Yang L, Hou Z*, Si W*, Zheng B*. Pyroptosis of MCF7 Cells Induced by the Secreted Factors of hUCMSCs. Stem Cells Int. 2018:5912194. 5. Fu X#, Jiang B#, Zheng B#, Yan Y, Wang J, Duan Y, Li S, Yan L, Wang H, Chen B, Sang X, Ji W*, Xu R*, Si W*. Heterogenic transplantation of bone marrow-derived rhesus macaque mesenchymal stem cells ameliorates liver fibrosis induced by carbon tetrachloride in mouse. PeerJ. 2018, 6:e4336. 6. Fu X#, Yan Y#, Li S, Wang J, Jiang B, Wang H, Duan Y, Tan T, Gao F, Gong D, Niu Y, Ji W*, Zheng B*, Si W*. Vitrification of Rhesus Macaque Mesenchymal Stem Cells and the Effects on Global Gene Expression. Stem Cells Int. 2017:3893691. 7. Chen B#, Li S#, Yan Y, Duan Y, Chang S, Wang H, Ji W*, Wu X*, Si W*. Cryopreservation of cynomolgus macaque (Macaca fascicularis) sperm with glycerol and ethylene glycol, and its effect on sperm-specific ion channels - CatSper and Hv1. Theriogenology. 2017, 104:37-42. 8. Yan Y, Ao L, Wang H, Duan Y, Chang S, Chen B, Zhi D, Li S, Niu Y, Ji W, Si W*. Optimization of cryopreservation of cyomolgus macaque (Macaca fascicularis) sperm with commercial egg yolk free SpermCryo All-round medium. J Am Assoc Lab Anim Sci. 2016, 55:744-748. 9. Wang H, Tan T, Wang J, Niu Y, Yan Y, Guo X, Kang Y, Duan Y, Chang S, Liao J, Si C, Ji W*, Si W*. Rhesus monkey model of liver disease reflecting clinical disease progression and hepatic gene expression analysis. Sci Rep. 2015;5:15019. 10. Yang S, Ping S, Ji S, Lu Y, Niu Y, Wang H,Ji W, Si W*. The positive effects of seminal plasma during freezing process on cryosurvival of sperm with poor freezability in Rhesus Macaque (Macaca mulatta). J Reprod Dev. 2011, 57:737-43. 11. Yang S, Ping S, Si W*, He X, Wang X, Lu Y, Ji S, Niu Y, Ji W. Optimize Ethylene Glycol Concentrations, Freezing Rates and Holding Times in Liquid Nitrogen Vapor for Sperm Cryopreservation of Rhesus Macaque (Macaca mulatta). J Vet Med Sci. 2011, 73:717-723. 12. Si W, Lu Y, He X, Ji S, Niu Y, Tan T, Ji W. Directional freezing as an alternative method for cryopreserving rhesus macaque (Macaca mulatta) sperm. Theriogenology. 2010, 74:1431–1438. 13. Si W, Men H, Benson JD, Critser JK. Osmotic characteristics and fertility of murine spermatozoa collected in different solutions. Reproduction. 2009, 137:215-223. 14. Si W, Benson JD, Men H, Critser JK. Osmotic tolerance limits and effects of cryoprotectants on the motility, plasma membrane integrity and acrosomal integrity of rat sperm. Cryobiology. 2006. 53:336-48. 15. Si W, Wang H, Reid C, Hildebrandt TB, Ji W. Effect of sugar type on the survival of frozen-thawed rhesus monkey (Macaca mulatta) sperm. Am J Primatol. 2006. 68:103-108. 16. Si W, Hildebrandt TB, Reid C, Krieg R, Ji W, Fassbender M, Hermes R. The successful double cryopreservation of rabbit (Oryctolagus cuniculus) semen in large volume using the directional freezing technique with reduced concentration of cryoprotectant. Theriogenology. 2006. 65:788-798. 17. Si W, Zheng P, Li Y, Dinnyes A, Ji W. Effect of glycerol and dimethyl sulfoxide on cryopreservation of rhesus monkey (macaca mulatta) sperm. Am J Primatol, 2004. 62:301-306. 18. Si W, Zheng P, Tang X, He X, Wang H, Bavister BD, Ji W. Cryopreservation of rhesus monkey (macaca mulatta) spermatozoa and functional assessment by in vitro fertilization. Cryobiology. 2000. 41: 232-240.

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