个人简介
王畅:女,副教授。1995年考入陕西师范大学化学系,1999年毕业获得理学学士学位。同年九月考入该校化学系,从事化学发光和微流控芯片的研究,于2002年获得理学硕士学位。同年九月开始在中科院大连化学物理研究所攻读博士学位,在导师许国旺研究员的指导下从事代谢组学研究——电喷雾质谱和液相色谱-质谱联用技术的磷脂分析方法研究及其在磷脂代谢中的应用。2006年3月于中国科学院大连化学物理研究所获得理学博士学位。2015.6-2016.6在美国加州大学戴维斯分校做访问学者,进行氧化脂类(oxylipin)的研究。2006年4月起至今于苏州大学工作,从事辐射损伤标志物以及放射生物学效应研究。
研究领域
1.基于代谢组学的辐射损伤生物标志物研究
2.放射生物学效应研究
近期论文
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1、Xueting Yao, Chao Xu,Yurong Cao, Lin Lin,Hanxu Wu,Chang Wang*. Early metabolic characterization of brain tissues after whole body radiation based on gas chromatography-mass spectrometry in a rat model. Biomed Chromatogr. 2018, doi: 10.1002/bmc.4448.
2、Bingyu Yang, Chang Wang#, Yiyu Xie, Liangjing Xu, Xiaojin Wu, Depei Wu. Monitoring tyrosine kinase inhibitor therapeutic responses with a panel of metabolic biomarkers in chronic myeloid leukemia patients.Cancer Sci. 2018, Cancer Sci, 109(3): 777-784.
3、Wu X, Xie Y, Wang C#, Han Y, Bao X, Ma S, Yilmaz A, Yang B, Ji Y, Xu J, Liu H, Chen S, Zhang J, Yu J, Wu D. Prediction of acute GVHD and relapse by metabolic biomarkers after allogeneic hematopoietic stem cell transplantation. JCI Insight, 2018,3(9). pii: 99672. doi: 10.1172/jci.insight.99672.
4、Chen H, Pei H, Hu W, Ma J, Zhang J, Mao W, Nie J, Xu C, Li B, Hei TK, Wang C*, Zhou G. Long non-coding RNA CRYBG3 regulates glycolysis of lung cancer cells by interacting with lactate dehydrogenase A. Journal of Cancer,2018,9(14):2580-2588
5、Mingxiao Zhao, Kim KT Lau, Xian Zhou, Jianfang Wu, Jun Yang, Chang Wang*.Urinary Metabolic Signatures and Early Triage of Acute Radiation Exposure in Rat Model. Molecular BioSystems, 2017, 13(4):756-766.
6、赵明晓,鲍协炳,陈怀远,吴小津,王畅*.需行全身照射患者辐射损伤血浆代谢谱的研究.中华放射医学与防护杂志,2017,37(1):7-11。
7、Yuanyuan Zhang, Xian Zhou, Chao Li, Jianfang Wu, John E. Kuo, Chang Wang*, Assessment of early triage for acute radiation injury in rat model based on urinary amino acid target analysis, Molecular BioSystems, 2014, 10(6): 1441-1449.
8、Xinxing Tang, Yuan Gu, Jihua Nie, Saijun Fan, Chang Wang*. Quantification of amino acids in rat urine by solid phase extraction and liquid chromatography/electrospray tandem mass spectrometry: application to radiation injury rat model. Journal of Liquid Chromatography & Related Technologies, 2014, 37(7): 951-973.
9、Xinxing Tang, Mingchen Zheng,Yuanyuan Zhang, Saijun Fan, Chang Wang*. Estimation value of plasma amino acid target analysis to the acute radiation injury early triage in the rat model. Metabolomics, 2013 (9): 853-863.
10、汤新星,顾源,蔡尚,徐美玲,王畅*.固相萃取-高效液相色谱-电喷雾串联质谱技术分析大鼠血浆中的氨基酸及其在电离辐射损伤动物模型中的应用. 色谱,2012, 7(30):696-704.
11、顾源汤新星张圆圆姚雪婷王畅*.电离辐射致大鼠肠上皮细胞磷脂变化的研究. 中华放射医学与防护杂志,2013,33(5):457-462.
12、Chang Wang*, Yun Yang, Jihua Nie. Plasma phospholipid metabolic profiling and biomarkers of rats following radiation exposure based on liquid chromatography–mass spectrometry technique. Biomed.Chromatogr,2009, 23: 1079-1085.
13、Chang Wang, Hongwei Kong, Yufeng Guan, Jun Yang, Jianren Gu, Shengli Yang, Guowang Xu. Plasma Phospholipid Metabolic Profiling and Biomarkers of Type 2 Diabetes Mellitus Based on High Performance Liquid Chromatography/Electrospray Mass Spectrometry and Multivariate Statistical Analysis. Anal. Chem., 2005,77:4108-4116
14、Chang Wang, Jun Yang, Peng Gao, Xin Lu,Guowang Xu. Identification of phospholipid structures in human blood by direct-injection quadrupole-linear ion-trap mass spectrometry. Rapid Commun. Mass Spectrom. 2005, 19: 2443–2453
15、Chang Wang, Sigang Xie, Jun Yang, Qing Yang, Guowang Xu. Structural Identification of Human Blood Phospholipids Using Liquid Chromatography/Quadrupole-linear ion trap Mass Spectrometry. Anal. Chim.Acta, 2004, 525(1):1-10