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个人简介

刘芬菊  苏州大学医学部放射医学与防护学院 教授,现任苏州大学医学部放射医学与防护学院放射生物学教研室主任。1978年毕业于苏州医学院放射医学专业。1993年获得苏州医学院放射生物学医学硕士学位。之后长期从事正常淋巴细胞及其亚群的辐射效应和肿瘤细胞放射生物学基础与临床相关课题的研究。曾主持及合作完成多项国家自然基金及省市科技厅科研项目。发表SCI及中文核心期刊学术论文80余篇,其中SCI收录16篇,包括European Radiology, Free Radical Biology and Medicine, Experimental Cell Research等,获得省部级科技进步三等奖3项及省国防科工办科技进步一等奖1项;市厅级二等1项和三等3项。主编及参编高校本科教材3本;参编专著1本。担任中国核医学会辐射研究与辐射工艺学会常务理事,《辐射研究与辐射工艺学报》副主编;卫生部医学参考报放射医学与防护频道常务编委,《核技术》及《放射医学与防护杂志》杂志审稿人。

研究领域

1. 电离辐射对正常及其肿瘤细胞DNA损伤与修复机制的研究 2. 脑胶质瘤辐射抗性基因与放射敏感性的相关性研究 3. 能量代谢与肿瘤放射敏感性的研究 4. 抗辐射蛋白在辐射损伤与救治中的作用机制研究

近期论文

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1.Wang Zhongmin, Liu Yu, Liu Fenju, Chen kemin, Huang Gang. Clinical efficacy of CT-guided iodine-125 seed implantation therapy in therapy in patients with advanced pancreatic cancer. European Radiology (IF=3.65), 2010, 20: 1786–1791. (Ⅱ区,通讯作者) 2. Xiaopeng Yuan, Jie Du,Song Hua,Haowen Zhang,Cheng Gu, Jie Wang,Lei Yang,Jianfeng Huang,Jiahua Yu*,Fenju Liu*,Suppression of autophagy augments the radiosensitizing effects of STAT3 inhibition on human glioma cells,Experimental Cell Research,DOI:10,1016/j.yexcr.2014.09.006, (Ⅱ区,通讯作者) 3. Haowen Zhang, Cheng Gu, Jiahua Yu, Zhongmin Wang, Xiaopeng Yuan, Lei Yang, Jie Wang, Yanshuang Jia, Jianjun Liu, Fenju Liu*. Radiosensitization of glioma cells by TP53-induced glycolysis and apoptosis regulator knockdown is dependent on thioredoxin-1 nuclear translocation. Free radical biology and medicine, 2014; 69C:239-248. (5-Year Impact Factor:5.969) (Ⅱ区,通讯作者) 4.Zhong-Min Wang,JianLu,TaoLiu,Ke-MinChen,GangHuang,Fen-Ju Liu CT-guided interstitial brachytherapy ofinoperablenon-smallcelllungcancer Lung Cancer 74 (2011) 253-257(Ⅲ区,通讯作者) 5.Wang Jie,Yuan Xiaopeng,Gu Cheng,Huang Jianfeng,Yu Jiahua*,Liu Fenju*,GSN antibody pretreatment aggravates radiation-induced lung injury in mice, Nuclear Science and Techniques,2014,25(2): 020301. (Ⅳ区,通讯作者) 6 Chen Yang 1,2* Ran Zhu,1* Jianmei Wan,1Bo Jiang,3Dayong Zhou ,4Miaoli Song,2angFenju Liu1 Biological Effects of Irradiationg Hepatocellular Carcinoma Cells by Internal Exposure with 125I-Labeled 5-Iodo-2’-Deoxyuridine-Chitosan Drug Loading Nanoparticles Cancer Biotherapy and Radiopharmaceuticals volume 29,Number 9,2014 May Ann Liebert,Inc.DoI:10.1089/2014.1693(通讯) 7. Yuanyuan Xu*, Lei Yang*, Xin Jiang,Jiahua Yu.Jicheng Yang.Haowen Zhang.Guomei Tai.Xiao Peng Yuan.Fenju Liu et al. Adenovirus-mediated coexpression of DCX and SPARC radiosensitizes human malignant glioma cells. Cellular and Molecular Neurobiology,(2013)33:965-971DOI 10.1007/s10571-013-9963-2 (Ⅲ区,通讯作者) 8. LIU Haiyan*, XU Yuanyuan*, CHEN Yun, JIANG Xin, YU Jiahua, YANGLei, GU Cheng and LIU Fenju. Semaphorin3B modulates radiosensitivity in hu-man glioma U-87MG cells. Nuclear Science and Techniques, 2013;24(2) (Ⅳ区,通讯作者) 9.Wang Zhongmin, Huang Xunbo, Cao Jun, Huang Guang, Chen Kemin, Liu Yu, Liu Fenju. Intraluminal radioactive stent compared with covered stent alone for the treatment of malignant esophageal stricture. Cardiovasc Intervent Radiol. 2012 Apr;35(2):351-8. doi: 10.1007/s00270-011-0146-6. Epub 2011 Mar 24.(通讯作者) 10.Haiyan Liu, Yuanyuan Xu, Yun Chen, Haowen Zhang, Saijun Fan and Fenju Liu* RNA interference Against SPARC promotes the growth of U-87MG human malignant glioma cells. Oncol Lett, 2011(2):985-990(Ⅳ区,通讯作者) 11 .FENG Shuang,WANG Jie, JIANG Xin, XU Yuanyuan, ZHANG Haowen, Cao Jianping, YU Jiahua, LIU Fenju*.Microarray screening of differentially expressed genes in DCX transfected U87 cells before and after irradiation. Nuclear Science and Techniques. Nuclear Science and Techniques. 2012(23):97-102. (Ⅳ区,通讯作者)

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