陈重 - 苏州大学 - 医学部药学院

个人简介

教育背景： 2006.9－2009.6 河南大学中药学硕士研究生（药物化学方向，与上海药物所联合培养） 2011.9－2015.6 苏州大学药学博士研究生（药物化学方向） 2016.7－2017.9 美国北卡罗来纳州立大学教堂山分校药学院访问学者（Eshelman School of Pharmacy, University of North Carolina at Chapel Hill）工作经历： 2004.8－2006.8 上海金谷生物医学有限公司质量主管 2009.8－2018.6 苏州大学药学院研究实习员，助理研究员 2018.7－至今苏州大学药学院高级实验师

研究领域

1）天然产物药用活性成分的发现研究，包括天然产物分离、结构鉴定与结构修饰、抗肿瘤，抗HIV-1生物活性评价、新靶点与新作用机制研究； 2）基于结构的药物分子设计，涉及的靶点包括EGFR-T790M、VEGFR等；

近期论文

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1. Chen, Z.,Duan H.Q., Tong,X.H., Hsu, P.L., Han, L., Morris-Natschke, S., Yang, S.L., Liu, W. *; Lee, K.H. *Cytotoxicity, Hemolytic Toxicity, and Mechanism of Action of Pulsatilla Saponin D and Its Synthetic Derivatives. J Nat. Prod.,2018, 81,465-474. 2. Tong,X.H. , Han,L. Duan, H.Q, Cui Y.R.，Feng, Y. L.， Zhu,Y.M.，Chen Z.* ,Yang,S.L.，The derivatives of Pulsatilla saponin A, abioactive compound from Pulsatilla chinensis: Their synthesis, cytotoxicity, haemolytic toxicity and mechanism of action，Eur. J. Med. Chem., 2017,129, 325~336. 3. Chen Z., Duan H.Q., Jiang X., Zhu Y.M.*, Ji, S.J.*, Yang S.L. Palladium-catalyzed domino synthesis of 4-amino-3-acyl-2-naphthols via Isocyanide Chemoselective Insertion. J. Org. Chem. 2015, 80, 8183−8188. 4. Chen Z., Duan H.-Q., Wang M.-L, Han L., Liu Y.-L., Zhu Y.-M.*, Yang S.-L*.Synthesis, cytotoxicity and haemolytic activity of Pulsatilla Saponin A, D derivatives.Bioorg. Med. Chem. Lett., 2015, 25, 2550-2554. 5. Chen Z., Duan H.-Q., Jiang X.; Wang J.-M., Zhu Y.-M.*, Yang S.-L.Palladium-catalyzed synthesis of biarylketones via tert-butyl isocyanide insertion. Synlett, 2014, 25, 1425-1430. 6. Chen Z., Liu Y.-L., Xu Q.-M*, liu J.-Y, Duan H.-Q., Yang S.-L. New polyoxygenated cyclohexene and polyoxygenated seco-cyclohexene from Uvaria boniana . J Asian Nat. Prod. Res., 2013, 15, 53-58. 7. Chen Z., Liu X.-R., Liu Y.-L., Xu Q.-M*, Yang S.-L. Two new flavones from Uvaria macrophylla Roxb.var. microcarpa and their cytotoxic activities . Heterocycles, 2011, 83, 2857-2863. 8. Duan H.-Q., Chen Z., Han, L., Feng, Y.-L.,Zhu Y.-M.*, Yang S.-L*. Palladium- catalyzed chemoselective synthesis of indane-1,3-dione derivatives via tert-butyl isocyanide insertion. Org. Biomol. Chem., 2015, 13, 6782–6788 9. Tang T, Fei X.-D., Ge Z.-Y, Chen Z., Zhu Y.-M.*, Ji, S.-J.*. Palladium-catalyzed carbonylative sonogashira coupling of aryl bromides via tert-butyl isocyanide insertion.J Org. Chem. 2013, 78, 3170-3175. 10. Jiang X, Tang T, Wang J.-M., Chen Z., Zhu Y.-M.*, Ji, S.-J.*. Palladium- Catalyzed One-Pot Synthesis of Quinazolinones via tert-Butyl Isocyanide nsertion. J Org. Chem. 2014, 79, 5082-5087. 11. Jiang X, Wang J.-M., Zhang Y, Chen Z., Zhu Y.-M.*, Ji, S.-J.*. Palladium-CatalyzedFormylation of Aryl Halides with tert-Butyl Isocyanide. Org. Lett.2014, 16, 3492-3495. 12. Li S.-S., Zhao J.-P., Liu Y.-L., Chen Z., Xu Q.-M.*, Khan, IA, Yang S.-L. New triterpenoid saponins from Ilex cornuta and protective effects against H2O2-induced myocardial cell injury, J. Agric. Food Chem., 2014, 62, 488-496. 13. Shu Z., Chen Z., Liu Y.-L., Zhu W.-F., Feng Y.-L., Xu Q.-M.*, Li X.-R., Yang S.-L.A new oleanane-type triterpenoidal saponin from Pulsatilla chinensis. Nat. Prod. Res., 2013, 27, 2196-2013. 14. Li X., Zhao J.-P., Peng C.-P., Chen Z., Liu Y.-L., Xu Q.-M.*, Khan IA,Yang S.-L.Cytotoxic triterpenoid glycosides from the roots of Camelliaoleifera. Planta Med., 2014, 80, 590-598. 15. Wang S.-L., Chen Z., Tong X.-J., Liu Y.-L., Li X., Xu Q.-M.*, Li X.-R., Yang S.-L.Triterpenoids from the roots of Camellia oleifera C. Abel and their cytotoxic activities. Helv. Chim. Acta,2013, 96, 1126-1133.