盛瑞 - 苏州大学 - 医学部药学院

个人简介

教育经历： 2001/9 - 2006/12，苏州大学，心血管药理学，博士 1997/9 - 2000/6，中国药科大学，神经药理学，硕士 1992/9 - 1997/6，中国药科大学，药理学，学士国外学习研究经历： 2011/5 - 2012/7，美国哈佛大学医学院，中风与血管调节实验室，访问学者 2012/8 -2012/10，美国洛杉矶大学加州分校，PBL教学培训

研究领域

中国药理学会会员，World Stoke Organization（世界中风学会）会员，江苏州省药理学会青年工作委员会副主任委员。1997年毕业于中国药科大学药理学专业，2000年获中国药科大学神经药理学硕士学位，2006年获得苏州大学医学博士学位，2010年确定为硕士生导师，2012年确立为江苏省青蓝工程优秀青年骨干教师，2016年任苏州大学药理学系教授。2011年-2012年在美国哈佛大学麻省总医院神经科学中心中风与血管调节实验室访学。2012年8月－10月在美国洛杉矶大学加州分校参加PBL教学培训。主要从事心脑血管药理研究，在Autophagy,Cell Death & Disease, J Biol Chem, Int J Cardiol等杂志上发表SCI科研论文30余篇，总引用次数达到1200余次。主持国家自然科学基金课题四项、江苏省自然科学基金课题一项以及苏州市发展基金课题一项。论文成果曾为人民日报、科学时报等报道，荣获高等学校科学研究优秀成果奖（科学技术）一等奖、第六届世界中风会议青年学者奖、霍英东教育基金会第十二届高等院校青年教师奖三等奖、苏州市科技进步奖二等奖、中国药理学会施维雅优秀青年药理学工作者等荣誉。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

[1] Sheng R*, Chen JL, Qin ZH . Cerebral Conditioning: Mechanisms and Potential Clinical Implications. eNeuroscience, 2018, 0(0): doi:10.14336/EN.2018.0128 [2] Song DD, Zhou JH, Sheng R*. Regulation and function of sphingosine kinase 2 in diseases. Histol Histopathol. 2017 Oct 19:11939(*corresponding author). [3] Song DD, Zhang TT, Chen JL, Xia YF, Qin ZH, Waeber C, Sheng R*. Sphingosine kinase 2 activates autophagy and protects neurons against ischemic injury through interaction with Bcl-2 via its putative BH3 domain. Cell Death Dis. 2017 Jul 6;8(7): e2912 (*corresponding author) [4] Zhou JH, Zhang TT, Song DD, Xia YF, Qin ZH, Sheng R*. TIGAR contributes to ischemic tolerance induced by cerebral preconditioning through scavenging of reactive oxygen species and inhibition of apoptosis. Sci Rep. 2016; 6:27096.(*corresponding author) [5] Sheng R*, Qin ZH. The divergent roles of autophagy in ischemia and preconditioning. Acta Pharmacol Sin. 2015;36(4):411-20(*corresponding author). [6] Zhang XY, Zhang TT, Song DD, Zhou J, Han R, Qin ZH, Sheng R*. Endoplasmic reticulum chaperone GRP78 is involved in autophagy activation induced by ischemic preconditioning in neural cells. Mol Brain. 2015;8:20(*corresponding author). [7] Sheng R, Zhang TT, Felice VD, Qin T, Qin ZH, Smith CD, Sapp E, Difiglia M, Waeber C. Preconditioning stimuli induce autophagy via sphingosine kinase 2 in mouse cortical neurons. J Biol Chem 2014; 289(30): 20845-57. [8] Gao B, Zhang XY, Han R, Zhang TT, Chen C, Qin ZH, Sheng R#. The endoplasmic reticulum stress inhibitor salubrinal inhibits the activation of autophagy and neuroprotection induced by brain ischemic preconditioning. Acta Pharmacol Sin 2013;34(5):657-66. (#corresponding author) [9] Sheng R, Gu ZL, Xie ML. Epigallocatechin gallate, the major component of polyphenols in green tea, inhibits telomere attrition mediated cardiomyocyte apoptosis in cardiac hypertrophy. Int J Cardiol 2013;162(3):199-209. [10] Sheng R, Liu XQ, Zhang LS, Gao B, Han R, Wu YQ, Zhang XY, Qin ZH. Autophagy regulates endoplasmic reticulum stress in ischemic preconditioning. Autophagy 2012; 8(3): 310-325. [11] Sheng R, Zhang LS, Han R, Gao B, Liu XQ, Qin ZH. Combined Prostaglandin E1 and lithium induces bcl-2 and heat shock proteins while inhibits p53 in a rat model of cerebral ischemia1 Acta Pharmacol Sin 2011; 32: 303-10. [12] Sheng R, Zhang LS, Han R, Liu XQ, Gao B, Qin ZH. Autophagy activation is associated with neuroprotection in a rat model of focal cerebral ischemic preconditioning. Autophagy 2010, 6: 482-94. [13] Sheng R, Gu ZL, Xie ML, Zhou WX, Guo CY. Epigallocatechin gallate protects H9c2 cardiomyoblasts against hydrogen dioxides- induced apoptosis and telomere attrition. Eur J Pharmacol 2010, 641:199-206. [14] Sheng R, Gu ZL*, Xie ML, Zhou WX, Guo CY. EGCG inhibits proliferation of cardiac fibroblasts in the rats with cardiac hypertrophy. Planta Medica. 2009, 75:113-20. [15] #Wen YD, #Sheng R, Zhang LS, Han R, Zhang X, Zhang XD, Han F, Kohji F, Qin ZH*. Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways. Autophagy 2008; 4(6): 762-9. (#: These authors contribute equally to this work) [16] Sheng R, Gu ZL*, Xie ML, Zhou WX, Guo CY. EGCG inhibits cardiomyocyte apoptosis in pressure overload induced cardiac hypertrophy rats and protects cardiomyocyte from oxidative stress. Acta Pharmacol Sin 2007, 28(2): 191-201. [17] Sheng R, Liu GQ*. EDT，a tetrahydroacridine derivative, inhibits cerebral ischemia and protects rat cortical neurons against glutamate and NO-induced injury. Acta Pharmacol Sin 2003; 24(5): 390-393.