个人简介
EDUCATION
2004-2009 University of Science and Technology of China Ph.D in Neurobiology, November 2009
2000-2004 University of Science and Technology of China B.S. in Bioscience, July 2004
RESEARCH EXPERIENCE
2016-present Professor
Department of Pharmacology, Soochow University College of Pharmaceutical Sciences
2012-2016 Associate Professor
Department of Pharmacology, Soochow University College of Pharmaceutical Sciences
2010-2012 Postdoctoral Research Associate with Dr. Arthur Horwich
Yale University School of Medicine / Howard Hughes Medical Institute (HHMI)
2004-2009 Ph.D Student with Dr. Guanghui Wang
Laboratory of Molecular Neuropathology, Department of Neurobiology, School of Life Sciences, University of Science and Technology of China
SCIENTIFIC TITLE AND AWARD
2015-present Associate Editor of the Journal of Alzheimer's Disease (JAD)
2010 Qiu Shi Graduate Student Scholarship by Hong Kong Qiu Shi Science & Technologies Foundation
研究领域
Increasing evidence indicates that further exploration of protein quality control system is critical for understanding the basic mechanism underlying neurodegenerative disorders including amyotrophic lateral sclerosis, Parkinson’s disease and Alzheimer’s disease. The goal of our studies is to describe how protein quality control systems, including autophagy-lysosome pathway and ubiquitin-proteasome system, fail to protect neurons at disease stages. To this end, we will use cell biology, molecular biology, biochemical approaches and genetic manipulation of animal models to investigate the relationship between protein quality control system and neurodegeneration.
近期论文
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1. Xia Q, Wang H, Hao Z, Fu C, Hu Q, Gao F, Ren H, Chen D, Han J, Ying Z* and Wang G* (2016). TDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion. EMBO J. 35(2):121-42. Notes: Cover story and highlighted in News & Views in this issue.
2. Ying Z, Xia Q, Hao Z, Xu D, Wang M, Wang H* and Wang G* (2016) TARDBP/TDP-43 regulates autophagy in both MTORC1-dependent and MTORC1-independent manners. Autophagy 12(4):707–8.
3. Xia Q, Wang G*, Wang H, Hu Q, Ying Z* (2016). Folliculin, a tumor suppressor associated with Birt-Hogg-Dube´ (BHD) syndrome, is a novel modifier of TDP-43 cytoplasmic translocation and aggregation. Hum Mol Genet. 25(1):83-96.
4. Xia Q, Hu Q, Wang H, Yang H, Gao F, Ren H, Chen D, Fu C, Zheng L, Ying Z*, Wang G* (2015). Induction of COX-2-PGE2 synthesis by activation of the MAPK/ERK pathway contributes to neuronal death triggered by TDP-43-depleted microglia. Cell Death Dis. 6:e1702.
5. Xia Q, Wang H, Zhang Y, Ying Z* and Wang G* (2015). Loss of TDP-43 Inhibits ALS-linked Mutant SOD1 Aggresome Formation in an HDAC6-dependent Manner. J Alzheimers Dis. 45(2):373-86.
6. Tao Z, Wang H, Xia Q, Li K, Li K, Jiang X, Xu G, Wang G*, Ying Z* (2015). Nucleolar stress and impaired stress granule formation contribute to C9orf72 RAN translation-induced cytotoxicity. Hum Mol Genet. 24(9):2426-41.
7. Zhou L, Wang H, Ren H, Hu Q, Ying Z* and Wang G* (2015). Bcl-2 Decreases the Affinity of SQSTM1/p62 to Poly-Ubiquitin Chains and Suppresses the Aggregation of Misfolded Protein in Neurodegenerative Disease. Mol Neurobiol. 52(3):1180-9.
8. Hou X, Si J, Ren H, Chen D, Wang H, Ying Z, Hu Q, Gao F, Wang G (2015). Parkin represses 6-hydroxydopamine-induced apoptosis via stabilizing scaffold protein p62 in PC12 cells. Acta Pharmacol Sin. 36(11):1300-7.
9. Guo D, Ying Z, Wang H, Chen D, Gao F, Ren H, Wang G (2015). Regulation of autophagic flux by CHIP. Neurosci Bull. 31(4):469-79.
10. Zhou L, Wang H, Chen D, Gao F, Ying Z* and Wang G* (2014). p62/Sequestosome 1 Regulates Aggresome Formation of Pathogenic Ataxin-3 with Expanded Polyglutamine. Int J Mol Sci. 15(9):14997-15010.
11. Zhou L, Wang H, Wang P, Ren H, Chen D, Ying Z* and Wang G* (2013). Ataxin-3 protects cells against H2O2-induced oxidative stress by enhancing the interaction between bcl-xl and bax. Neuroscience. 243:14-21.
12. Zhou L, Wang H, Ren H, Chen D, Gao F, Hu Q, Fu C, Xu R, Ying Z* and Wang G* (2013). Bcl-2-dependent upregulation of autophagy by sequestosome 1/p62 in vitro. Acta Pharmacol Sin. 34(5):651-6.
13. Ying Z1, Wang H1, Wang G (2013). The ubiquitin proteasome system as a potential target for the treatment of neurodegenerative diseases. Curr Pharm Des. 19(18):3305-14. (1Co-first author)
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