王义鹏 - 苏州大学 - 医学部药学院

个人简介

学习经历： 2001.9-2005.7，聊城大学生命科学学院，工学学士 2005.9-2010.6，中国科学院昆明动物研究所，理学博士 2018.1-2018.12，哈佛医学院附属波士顿儿童医院，访问学者工作经历： 2010.7-2013.9，中国科学院烟台海岸带研究所，助理研究员 2013.9-至今，苏州大学药学院，副教授

研究领域

1、天然活性蛋白/多肽发掘 2、活性蛋白/多肽设计改造 3、活性蛋白/多肽应用研究

近期论文

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Feng L, Shi N, Cai S, Qiao X, Chu P, Wang H, Long F, Yang H, Yang Y, Wang YP*, Yu H*. De novo Molecular Design of Novel Octapeptide that Inhibits In Vivo Melanogenesis with Great Transdermal Ability. J Med Chem. 2018 61(15):6846-6857. Cai S, Qiao X, Feng L, Shi N, Wang H, Yang H, Guo Z, Wang M, Chen Y, Wang YP*, Yu H*. Python Cathelicidin CATHPb1 Protects against Multidrug-Resistant Staphylococcal Infections by Antimicrobial-Immunomodulatory Duality. J Med Chem. 2018 61(5):2075-2086. Shi N, Cai S, Gao J, Qiao X, Yang H, Wang YP*, Yu H*. Roles of polymorphic cathelicidins in innate immunity of soft-shell turtle, Pelodiscus sinensis. Dev Comp Immunol. 2018 16;92:179-192. Guo Z, Qiao X, Cheng R, Shi N, Wang A, Feng T, Chen Y, Zhang F, Yu H, Wang YP*. As-CATH4 and 5, two vertebrate-derived natural host defense peptides, enhance the immuno-resistance efficiency against bacterial infections in Chinese mitten crab, Eriocheir sinensis. Fish Shellfish Immunol. 2017 71:202-209. Wang A, Chen Y, Yu H, Wang YP*. Novel cathelicidins with potent antimicrobial, biofilm inhibitory, and anti-inflammatory activities from the frog Fejervarya multistriata. Asian Herpetol Res. 2017 8(3):199-212. Chen Y, Cai S, Qiao X, Wu M, Guo Z, Wang R, Kuang Y, Yu H, Wang YP*. As-CATH1-6, novel cathelicidins with potent antimicrobial and immunomodulatory properties from Alligator sinensis, play pivotal roles in host anti-microbial immune responses. Biochem J. 2017 474:2861-2885. Yu H, Wang C, Feng L, Cai S, Liu X, Qiao X, Shi N, Wang H, Wang YP*. Cathelicidin-trypsin inhibitor loop conjugate represents a promising antibiotic candidate with protease stability. Sci Rep. 2017 1;7(1):2600. Yu H, Wang H, Liu X, Feng L, Qiao X, Cai S, Shi N, Wang YP*. Identification, eukaryotic expression and structure & function characterizations of β-defensin like homologues from Pelodiscus sinensis. Dev Comp Immunol. 2017 68:108-117. Yu H, Cai S, Gao J, Wang C, Qiao X, Wang H, Feng L, Wang YP*. Express sequence tag analysis-identification of anseriformes trypsin genes from full-length cDNA library of the duck (Anas platyrhynchos) and characterization of their structure and function. Biochemistry (Moscow) 2016 81(2): 152-162. Yu H, Liu X, Wang C, Qiao X, Wu S, Wang H, Feng L, Wang YP*. Assessing the potential of four cathelicidins for the management of mouse candidiasis and Candida albicans biofilms. Biochimie. 2016 121: 268-277. Wei L, Gao J, Zhang S, Wu S, Xie Z, Ling G, Kuang Y, Yang Y, Yu H, Wang YP*. Identification and Characterization of the First Cathelicidin from Sea Snakes with Potent Antimicrobial and Anti-inflammatory Activity, and Special Mechanism. J Biol Chem. 2015 290(27): 16633-52. (该工作被Chem Res Toxicol杂志作为Spotlight介绍) Yu H, Lu Y, Qiao X, Wei L, Fu T, Cai S, Wang C, Liu X, Zhong S, Wang YP*. Novel Cathelicidins from Pigeon Highlights Evolutionary Convergence in Avain Cathelicidins and Functions in Modulation of Innate Immunity. Sci Rep. 2015 21;5:11082. Yu H, Qiao X, Wang C, Cai S, Liu X, Feng L, Wang H, Wang YP*. Identification and Characterization of Novel Antioxidant Peptides Involved in Redox Homeostasis of Frog, Limnonectes fragilis. Protein Pept Lett. 2015 22(9):776-84. Ling G, Gao J, Zhang S, Xie Z, Wei L, Yu H, Wang YP*. Cathelicidins from the bullfrog Rana catesbeiana provides novel template for peptide antibiotic design. PLoS ONE. 2014 27 9(3):e93216. Yu H, Cai S, Gao J, Zhang S, Lu Y, Qiao X, Yang H, Wang YP*. Identification and polymorphism discovery of the cathelicidins, Lf-CATHs in ranid amphibian (Limnonectes fragilis). FEBS J. 2013 Sep 13. Li Z, Zhang S, Guang H, Gao J, Guo H, He W, Wang YP*, Yu H. Structural and functional characterization of CATH_BRALE, the defense molecule in the ancient salmonoid, Brachymystax lenok. Fish Shellfish Immunol. 2013 34(1):1-7. He W, Feng F, Huang Y, Guang H, Zhang S, Li Z, Liu J, Wang YP*, Yu H. Host defense peptides in skin secretions of Odorrana tiannanensis: proof for other survival strategy of the frog than merely antimicrobial. Biochimie. 2012 94(3):649-55. Cui H＃, Wang YP＃, Wang Y, Qin S. Genome-wide analysis of putative peroxiredoxin in unicellular and filamentous cyanobacteria. BMC Evol Biol. 2012 16;12(1):220. (共享第一作者) Zhang S, Guo H, Shi F, Wang H, Li L, Jiao X, Wang YP*, Yu H*. Hainanenins: A novel family of antimicrobial peptides with strong activity from Hainan cascade-frog, Amolops hainanensis. Peptides. 2012 33(2):251-7. Wang YP, Zhang Z, Chen L, Guang H, Li Z, Yang H, Li J, You D, Yu H, Lai R*. Cathelicidin-BF, a snake cathelicidin-derived antimicrobial peptide, could be an excellent therapeutic agent for acne vulgaris. PLoS ONE. 2011 6(7):e22120.