梁中琴 - 苏州大学 - 医学部药学院

个人简介

学历背景： 1977.2－1980.1 苏州医学院医疗系本科 1993.9－1996.11 苏州医学院药理学硕士生国外学习研究经历： 2003.8－2005.1美国国立卫生研究院（NIH）高级访问及合作研究工作经历： 1980.1－2001.11 苏州医学院药理教研室，助教、讲师、副教授 2001.至今苏州大学医学部药学院药理学系教授

研究领域

（1）神经药理学：研究自噬/溶酶体信号分子参与PD发生的病理机制及作用靶点。（2）肿瘤药理学：研究Cathepsin L信号通路在调节胶质瘤干细胞辐射抗性中的作用及机制，为辐射抗性产生的机制提供新认识。

近期论文

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1) Zhuang W, Li B, Long L, Chen L, Huang Q, Liang Z*（2011）.Induction of autophagy promotes differentiation of glioma-initiating cells and their radiosensitivity. Int J Cancer 2011.Dec 1;129(11):2720-3. 2) Xiang B, Fei X, Zhuang W, Fang Y, Qin Z, Liang Z*（2011）. Cathepsin L is involved in 6-hydroxydopamine induced apoptosis of SH-SY5Y neuroblastoma cells. Brain Res. 28;1387:29-38. 3) Li L, Wang X, Fei X, Xia L, Qin Z, Liang Z*（2011）. Parkinson's disease involves autophagy and abnormal distribution of cathepsin L. Neurosci Lett. 1;489(1):62-7. 4) Zhuang W, Li B, Long L, Chen L, Huang Q, Liang ZQ*（2011）. Knockdown of the DNA-dependent protein kinase catalytic subunit radiosensitizes glioma-initiating cells by inducing autophagy. Brain Res. 31;1371:7-15. 5) Yu YX, Gu ZL, Yin JL, Chou WH, Kwok CY, Qin ZH, Liang ZQ*（2010）. Ursolic acid induces human hepatoma cell line SMMC-7721 apoptosis via p53-dependent pathway. Chin Med J (Engl).123(14):1915-23. 6) Fei XF, Qin ZH, xiang B, Li LY, Liang ZQ*（2009）. Olomoucine inhibits cathepsin L nuclear translocation, activates autophagy and attenuates toxicity of 6-hydroxydopamine. Brain Research，1264.85-97. 7) Wenzhuo Zhuang, Zhenghong Qin, and Zhongqin Liang*（2009）. The role of autophagy in sensitizing malignant glioma cells to radiation therapy. Acta Biochimica et Biophysica Sinica. 41(5):341-51. 8) Jun Li, Zhenghong Qin，and Zhongqin Liang*（2009）. The prosurvival role of autophagy in Resveratrol-induced cytotoxicity in human U251 glioma cells. BMC Cancer, 9:215. 9) Yan-Li Jia Jun Li; Zheng-Hong Qin; Zhong-Qin Liang*（2009） . Autophagic and apoptotic mechanisms of curcumin-induced death in K562 cells. Journal of Asian Natural Products Research, 11（11）：918–928. 10)Zhang L, Gu ZL, Qin ZH, Liang ZQ*（2008）. Effect of curcumin on the adhesion of platelets to brain microvascular endothelial cells in vitro. Acta Pharmacologica Sinica. 29 (7): 800-807. 11)Li LY, Zhao XL, Fei XF, Gu ZL, Qin ZH, Liang ZQ*（2008）. Bilobalide inhibits 6-OHDA -induced activation of NF-κB and loss of dopaminergic neurons in Rat Substantia Nigra. Acta Pharmacologica Sinica. 29 (5): 539-547. 12)Liang ZQ, Li YL, Zhao XL, Han R, Wang XX, Wang Y, Chase TN, Bennett MC, Qin ZH（2007）. NF-κB contributes to 6-hydroxydopamine-induced apoptosis of nigral dopaminergic neurons through p53. Brain Res. 1145: 190-203. 13)Fei XF, Qin ZH, Liang ZQ*（2007）. Contribution of CDP/Cux, a transcriptional factor, to cell cycle progress. Acta Biochimica et BiophysicaSin. 39: 923-930. 14)Yan CH, Gu ZL，Yang YP, Reid P, Qin ZH, Liang ZQ*（2007）. Autophagy is involved in cytotoxic effects of crotoxin in MCF-7 cells. Acta Pharmacological Sin. 28: 540-548. 15)Yang YP, Liang ZQ, Gao B, Jia YL, Qin ZH. Dynamic effects of autophagy on arsenic trioxide-induced death of human leukemia cell line HL60 cells. Acta Pharmacol Sin. 2008, 29: 123-134. 16)Liang ZQ, Wang XX, Wang Y, Chen RW, Chuang DM, Chase TN, Qin ZH. NF-kB-Dependent Cyclin D1 Induction Associated with N-Methyl-D-Aspartate Receptor-Mediated Apoptosis in Rat Striatum. J Neurosci Res. 85: 1295-1309. 17)Yan CH, Liang ZQ, Gu ZL,Yang YP, Reid P, Qin ZH. (2006) Contributions of autophagic and apoptotic mechanisms to crotoxin-induced death of K562 cells. Toxicon., 47: 521-30. 18)Liang ZQ, Wang XX, Wang Y, Chuang DM, DiFiglia M, Chase TN, Qin ZH. (2006). Susceptibility of Striatal Neurons to Excitotoxic Injury Correlates with Basal Levels of Bcl-2 and the Induction of P53 and c-Myc Immunoreactivity. Neurobiol of Disease. 20: 562-573. 19)Yang YP, Liang ZQ, Gu ZL, Qin ZH. (2005). Molecular mechanism and regulation of autophagy. Acta Pharmacol Sin.26: 1421-34.