张真庆 - 苏州大学 - 医学部药学院

个人简介

学历背景 1996.09 - 2000.06：中国海洋大学，药学 2000.09 - 2006.06：中国海洋大学，工学博士，研究方向糖科学工作经历 2006.08 - 2009.09：美国Rensselaer Polytechnic Institute, 博士后 2009.10 –2012.08：美国Baxter Healthcare,研究员 2012.08 – 目前：苏州大学药学院，教授

研究领域

1、肝素及肝素类药物的分析，鉴定 2、糖蛋白和蛋白聚糖的糖基化分析 3、活性糖链的生物合成、衍生以及蛋白的多糖修饰研究 4、活性糖链与抗肿瘤和抗神经退行性疾病的构效关系研究 5、糖类药物的研究与开发

近期论文

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1. M. Guerrini, D. Beccati, Z. Shriver, A. Naggi, K. Viswanathan, A. Bisio, I. Capila, J.C. Lansing, S. Guglieri, B. Fraser, A. Al-Hakim, N.S. Gunay, Z. Zhang, L. Robinson, L. Buhse, M. Nasr, J. Woodcock, R. Langer, G. Venkataraman, R.J. Linhardt, B. Casu, G. Torri, R. Sasisekharan*. Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events, Nature Biotechnolology, 2008, 26(6): 669-675. 影响因子31 2. M. Guerrini,1 Z. Zhang,1 Z. Shriver,1 A. Naggi , S. Masuko , R. Langer, B. Casu , R. J. Linhardt , G. Torri, R. Sasisekharan*, Orthogonal analytical approaches to detect potential contaminants in heparin, PNAS, 2009, 106, 16956-61. 1Co- first authors.影响因子9.8 3. Z. Zhang, S.A. McCallum, J. Xie, L. Nieto, F. Corzana, J. Jiménez-Barbero, M. Chen, J. Liu, R.J. Linhardt*. Solution Structures of Chemoenzymatically Synthesized Heparin and Its Precursors, Journal of the American Chemical Society, 2008, 130(39): 12998-3007.影响因子9.0 4. H. Liu, Z. Zhang, R.J. Linhardt*. Lessons learned from the contamination of heparin, Natural Product Reports (NPR), highlight paper, 2009, 26(3):313-321.影响因子7.7 5. Z. Zhang*, N. Khan, C.M. Szabo, Complete Monosaccharide Analysis by High Performance Anion Exchange Chromatography with Pulsed Amperometric Detection. Anal. Chem. 2012, 84, 4104-4110. 影响因子5.8 6. Z. Zhang, J. Xie, H. Liu, J. Liu, R.J. Linhardt*. Quantitification of Heparan Sulfate Disaccharides Using Ion-pairing, Reverse-Phase, Micro-flow, High Performance Liquid Chromatography with Electrospray Ionization Trap Mass Spectrometry. Analytical Chemistry, 2009, 81, 4349-4355. 影响因子5.8 7. Z. Zhang, M. Weïwer, B. Li, M.M. Kemp, T.H. Daman, R.J. Linhardt*. Oversulfated Chondroitin Sulfate: Impact of a Heparin Impurity, Associated with Adverse Clinical Events, on Low-Molecular-Weight Heparin Preparation. Journal of Medicinal Chemistry, 2008, 51(18): 5498-501. 影响因子5.2 8. Z. Zhang, J. Xie, J. Liu, R.J. Linhardt*. Tandem MS can distinguish hyaluronic acid from N-acetylheparosan, Journal of the American Society of Mass Spectrometry, 2008, 19(1): 82-90. 影响因子3.8 9. Z. Zhang, G. Yu, X Zhao, H. Liu, H Guan, A.M. Lawson W. Chai*. Sequence analysis of alginate-derived oligosaccharide by ESI/CID-MS/MS. Journal of theAmerican Society of Mass Spectrometry, 2006, 17, 621–630. “ SCI ” 影响因子3.8 10. Z. Zhang, J. Xie, F. Zhang, R.J. Linhardt*. Thin-layer chromatography for the analysis of glycosaminoglycan oligosaccharides. Analytical Biochemistry, 2007, 371(1): 118-120. “ SCI ” 影响因子3.3 11. Z. Zhang, Y. Park, M.M. Kemp, W. Zhao, D. Shaya, M. Cygler, Y.S. Kim, R.J. Linhardt*.Liquid chromatography–mass spectrometry to study chondroitin lyase action pattern,Analytical Biochemistry, 2009, 385(1): 57-64. 影响因子3.3 12. Z. Zhang, B. Li, J. Suwan, F. Zhang, R.J. Linhardt*. Analysis of pharmaceutical heparins and potential contaminants using 1H-NMR and PAGE, Journal of Pharmaceutical Science, 2009, 98(11):4017-4026. 影响因子3.0 13. Z. Zhang, R.J. Linhardt*. Sequence analysis of native oligosaccharides using negative ESI tandem MS, Current Anal. Chemistry, 2009, 5, 225-237. 影响因子2.1 14. Z. Zhang, G. Yu*, H. Guan, X. Zhao, Y. Du, X. Jiang, Preparation and structure elucidation of alginate oligosaccharides degraded by alginate lyase from Vibrio Sp510. Carbohydrate Research, 2004, 399,1475-1481.影响因子2.0 15. Z. Zhang, Z. Xiao, R.J. Linhardt*. Thin Layer Chromatography for the Separation and Analysis of Acidic Carbohydrates, Journal of Liquid Chromatography & Related Technologies, 2009, 1711-1732. 影响因子1.0 16. Z. Wang, B. Yang, Z. Zhang, M. Ly, M. Takieddin, S. Mousa, J. Liu, J. S. Dordick, R.J. Linhardt* Control of the heparosanN-1 deacetylation leads to animproved bioengineered heparin.Applied Microbiology and Biotechnology,2011,91-99. 影响因子3.3 17. G. Yu, Y. Zhang,Z. Zhang, L. Song, W. Chai*, The Effect and Limitation of Excess Ammonium on the Release of O-Glycansin Reducing Forms from Glycoproteins under Mild Alkaline Conditions for Glycomic and Functional Analysis.Analytical Chemistry,2010, 82, 9534-9542. 影响因子5.8 18. T. N. Laremore, M. Ly, Z. Zhang, K. Solakyildirim, S. McCallum, R. T. Owens, R. J. Linhardt*, LC-MS disaccharide composition analysis for the domain structure elucidation of decorin glycosaminoglycan.Biochemical Journal, 2010, 431:199-205. 影响因子5.2 19. Z. Xiao, W. Zhao, B. Yang, Z. Zhang, H. Guan, R. J. Linhardt*, HeparinaseⅠ susceptible 3,6-di-O-sulfo-2-deoxy-2- sulfamido- a-D-glucopyranose (1,4) 2-O-sulfo- a-L-idopyranosyluronic acid linkage. Glycobiology, 2011, 21: 13-22. “ SCI ” 影响因子3.9 D. Shaya, W. Zhao, M.L. Garron, Z. Xiao, Q. Cui, Z. Zhang, T. Sulea, R.J. Linhardt, M. Cygler, Catalytic mechanism of heparinase II investigated by site-directed mutagenesis and the crystal structure with its substrate. J. Biol. Chem, 2010, 25; 285(26):20051-61. 影响因子6.9 21. Z. Wang, Z. Zhang, SA McCallum, RJ Linhardt*, Nuclear magnetic resonance quantification for monitoring heparosan K5 capsular polysaccharide production. Analytical Biochemistry, 2010, 398, 275-277. 影响因子3.3