个人简介
教育背景
1989.9-1993.7 东北师范大学化学系，学士学位
1993.8-1996.7 北京师范大学化学系，硕士学位
1999.9-2004.8 美国凯斯西部保留地大学（Case Western Reserve University） 化学系, 博士学位
工作经历：
1996.8-1999.7 中国科学院北京化学研究所，研究助理
2004.9-2005.4 美国密执根大学（University of Michigan）化学系，博士后
2005.5-2007,12 美国明尼苏达大学（University of Minnesota）药物设计中心，博士后
2008,2- 江苏省苏州大学药学院，特聘教授，博士生导师， 合成药物化学教研室主任
获奖及荣誉：
1998 中科院北京化学所优秀青年科技工作者
2004 2004 PPG Merit Award, Outstanding Graduate Performance
2008 苏州市引进紧缺高层次人才
2009 苏州大学2009陈金荣生命科学英才奖科研成果二等奖
2011 江苏省第四期“333高层次人才培养工程”第三层次人才资助
近期论文
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1 Zhixiang Xu, Wei Yin, Leonardo K. Martinelli, Joanna Evans, Jinglei Chen, Yang Yu Daniel J. Wilson, Valerie Mizrahi, Chunhua Qiao*, Courtney C. Aldrich* Reaction intermediate analogues as bisubstrate inhibitors of pantothenate synthetaseBioorganic & Medicinal Chemistry, 2014, 22, 1726–1735.
2 Shu-hua Xiao, Chunhua Qiao, Jian Xuea, Lili Wang Mefloquine in combination with hemin causes severe damage toadult Schistosoma japonicum in vitro. Acta Tropica 2014,131, 71– 78
3 Lili Wang, Cong Li, Yingying Zhang, Chunhua Qiao, Yonghao Ye, Synthesis and biological evaluation of benzofuroxan derivatives as fungicides against phytopathogenic fungi, J. Agric. Food Chem. 2013, 61(36), 8632-8640.
4 Zhi-xia Wang, Jing-lei, Chen, Chunhua Qiao*, Praziquantel derivatives with antischistosomal activity: aromatic ring modification. Chemical Biology & Drug Design, 2013, 82, 2, 216-225.
5 Jinglei Chen, Weizhen Sun, Jingjing Yang, Huan Sun, Zhixia Wang, Lanlan Dong, Chunhua Qiao,* Chao-ming Xia,* Development of a novel class of pyrrolo-[1,2,5]benzothiadiazepine derivatives as potential anti-schistosomal agents Bioorg. Med. Chem. Lett. 2013,23,3785–3787
6 Xing Yan, Chunhua Qiao*, Zhong-Wu Guo Tin (IV) chloride promoted reaction of oxiranes with hydrogen peroxide SYNLETT. 2013, 24, 0502-0506.
7 Jian-zhong Wu, Zhixia Wang, Chunhua Qiao* Synthesis of Stagonolide C from Mulzer Epoxide Tetrahed Lett. 2012,53,1153-1155.
8 Wenwen, D.; Sijie, Q.; Yue, Z.; Chunhua, Qiao;* Chaoming, Xia*.; “Praziquantel Derivatives Exhibit Activity against both Juvenile and Adult Schistosoma japonicum” Bioorg.Med.Chem.Lett. 2012,22,1587-1590
9 Zhaoli Zhang, Jinglei Chen, Qiongming Xu，Chunhua Qiao* Efficient Synthesis of Hydroxytyrosol from 3,4-Dihydroxybenzaldehyde. Synth. Commun. 2012, 42, 6, 794-798
10 Huan-qiu, Li, Jing Yang, Shuhua Ma, Chunhua Qiao*, Structure-based design of rhodanine-based acylsulfonamide derivatives as antagonists of the anti-apoptotic Bcl-2 protein Bioorg. Med. Chem. 2012, 20, 4194–4200
11 XingYan, Jinglei Chen, Chunhua Qiao* Phosphomolybdic Acid Catalyzed Synthesis of 1,2,4,5-Tetraoxanes, SYNLETT. 2011, 19, 2827-2830.
12 Wei Yin, Chunhua Qiao* Synthesis of Epigoitrin from (R)-(+)-4-Hydroxy-γ-butyrolactone，J. Heterocycl. Chem In press.
13 Huan-Qiu Li*, Yin Luo，Chunhua Qiao* The Mechanisms of Anticancer Agents by Genistein and Synthetic Derivatives of Isoflavone Mini-Review Med. Chem. 2012，12，4，350-362
14 Chunhua Qiao, Amol Gulpte, Helena Boshoff, Daniel J. Wilson, Eric Bennett,Clifton E. Barry III, and Courtney C. Aldrich, “5’-O-[(N-Acyl)sulfamoyl]adenosines as Antitubercular Agents that Inhibit MbtA: An Adenylation Enzyme Required for Siderophore Biosynthesis of the Mycobactins. J. Med.Chem. 2007, 50, 6080-6094.
15 Chunhua Qiao, Daniel J. Wilson, Eric Bennett, and Courtney C. Aldrich, “A Mechanism-Based Aryl Carrier Protein/Thiolation Domain Affinity Probe” J. Am. Chem. Soc. 2007, 129, 6350-6351
16 Chunhua Qiao, Ke-Qing Ling, Eric M. Shepard, David M. Dooley, and Lawrence M. Sayre, “Mechanism-Based Cofactor Derivatization of a Copper Amine Oxidase by a Branched Primary Amine Recruits the Oxidase Activity of the Enzyme to Turn Inactivator into Substrate”J. Am. Chem. Soc. 2006, 128, 6206-6219
17 Ravindranadh Somu, Helena Boshoff, Chunhua Qiao, Eric Bennett, Clifton E. Barry III, and Courtney C. Aldrich, “Rationally Designed Nucleoside Antibiotics that Inhibit Siderophore Biosynthesis of Mycobacterium tuberculosis” J. Med. Chem. 2006, 49, 31-34.
18 Miri Yoon, Anjali Patwardhan, Chunhua Qiao, Steven O. Mansoorabadi, Ann L. Menefee, George H. Reed, and E. Neil G. Marsh, “Reaction of Adenosylcobalamin-Dependent Glutamate Mutase with 2-Thiolglutarate”Biochemistry, 2006, 45, 11650-11657
19 Chunhua Qiao, and E. Neil G. Marsh, “Mechanism of Benzylsuccinate Synthase: Stereochemistry of Toluene Addition to Fumarate and Maleate” J. Am. Chem. Soc. 2005, 127, 8608-8609
20 Chunhua Qiao, Heung-Bae Jeon, and Lawrence M. Sayre, “Selective Inhibition of Plasma Amine Oxidase by Homopropargylamine, a New Inactivator Motif” J. Am. Chem. Soc. 2004, 126, 8038-8045
21 Zbynek Lamplot, Marek Sebela, Michal Malon, Rene Lenobel, Karel Lemr, Jan Havlis, Pavel Pec, Chunhua Qiao, Lawrence M. Sayre, “1,5-Diamino-2-pentyne is both a substrate and inactivator of plant copper amine oxidases” Eur. J. Biochem., 2004, 271(23/24) , 4696-4708
22 Heung-Bae Jeon, Younghee Lee, Chunhua Qiao, He Huang, and Lawrence M. Sayre, “Inhibition of Bovine Plasma Amine Oxidase by 1,4-diamino-2-butenes and -2-butynes” Bioorg. Med. Chem., 2003, 11, 4631-4641
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