张慧灵 - 苏州大学 - 医学部药学院

个人简介

2005年获苏州大学医学博士学位。2006年11月-2008年11月在美国哈佛大学脑中风实验室做博士后。2009年任苏州大学教授。2002年被评为苏州市新世纪高级青年专业技术人才及江苏省“青蓝工程”优秀骨干教师。2002年获苏州大学讲课比赛一等奖。2006年被确定为江苏省六大人才高峰。

研究领域

张慧灵教授主要从事缺血性脑损伤的分子信号机制及药物研发，包括缺血性脑损伤神经元和星形胶质细胞死亡的形式、分子信号机制及药物干预

近期论文

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Qin AP, Liu CF, Qin YY, Hong LZ, Xu M, Yang L, Liu J, Qin ZH,Zhang HL.Autophagy was activated in injured astrocytes and mildly decreased cell survival following glucose and oxygen deprivation and focal cerebral ischemia. Autophagy 2010，6:738-53. Zhang HL, Xu M, Wei C, Qin AP, Liu CF, Hong LZ, Zhao XY, Liu J, Qin ZH. Neuroprotective effects of pioglitazone in a rat model of permanent focal cerebral ischemia are associated with PPARγ-mediated suppression of NF-kB signaling pathway. Neuronscience 2011, 176:381-395. Xu M, Zhang HL. Death and survival of neuronal and astrocytic cells in ischemic brain injury: a role of autophagy. Acta Pharmacol Sin 2011 Aug 1 [Epub ahead of print] Zhang HL, Gu ZL, Savitz SI, Han F, Fukunaga K, Qin ZH. Neuroprotective effects of prostaglandin A1 are associated with NF-kB inhibition and PPAR γ upregulation in rat models of focal ischemia. J Neuroscience Res 2008, 86: 1132-1147. Wang X, Qin ZH, Shi H, Savitz SI, Qin AP, Jiang Y, Zhang HL. Protective effect of Ginkgolids (A+B) is associated with inhibition of NIK/IKK/IkB/NF-kB signaling pathway in a rat model of permanent focal cerebral ischemia. Brain Research 2008, 1234：8-15. Zhang HL, Huang Z, Gu ZL, Zhu Y, Liang ZQ, Han R, Wang XX, Chase TN, Qin ZH. Neuroprotective effects of prostaglandin A1 in animal models of focal ischemia. Brain Research 2005, 1039:203-206. Zhang HL,Chen ZX, Gu ZL, Chen BW, Han R, Reid PF, Raymond LN, Qin ZH. Opiate and acetylcholine-independent analgesic actions of crotoxin. Toxicon 2006, 48: 175-182.