谢梅林 - 苏州大学 - 医学部药学院

个人简介

学历背景： 1979.9－1984.7 苏州医学院大学本科 1987.9－1990.7 苏州医学院药理学硕士生 1995.9－1998.7 中国中医科学院中西医结合心血管内科博士生, Ph.D 1999.3－2001.2 上海中医药大学博士后研究人员工作经历： 1984.7－1987.9 苏州医学院药理教研室助教 1990.7－1995.9 苏州医学院药理教研室助教、讲师 1998.7－1999.2 苏州医学院药理教研室副教授 2001.2－现在苏州大学教授,2004年始任博导

研究领域

（1）心血管药理学（2）调脂与抗炎药物的分子机制研究（3）天然药物作用及相关机制研究

近期论文

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1. Rong Chen, Jie Xue, Mei-Lin Xie*. Reduction of isoprenaline- induced myocardial TGF-β1 expression and fibrosis in osthole- treated mice. Toxicology and Applied Pharmacology, 2011, 256: 168-173. 2. Rao Du, Jie Xue, Heng-bin Wang, Yan Zhang, Mei-lin Xie*. Osthol ameliorates fat milk-induced fatty liver in mice by regulation of hepatic sterol regulatory element-binding protein-1c/2-mediated target gene expression. European Journal of Pharmacology, 2011, 666: 183-188. 3. Zhigang Qi, Jie Xue, Yan Zhang, Hengbin Wang, Meilin Xie*. Osthole ameliorates insulin resistance by increment of adiponectin release in high-fat and high-sucrose-induced fatty liver rats. Planta Medica, 2011, 77: 231-235. 4. Jianjun Zhang, Jie Xue, Hengbin Wang, Yan Zhang and Meilin Xie*. Osthole improves alcohol-induced fatty liver in mice by reduction of hepatic oxidative stress. Phytotherapy Research, 2011, 25:638-643. 5. Jie Xue, Yinan Hua, Meilin Xie*, Zhenlun Gu. Aspirin inhibits MMP-9 mRNA expression and release via the PPARα/γ and COX-2/mPGES-1-mediated pathways in macrophages derived from THP-1 cells. Biomedicine & Pharmacotherapy, 2010, 64: 118-123. 6. Fan Sun, Mei-lin Xie*, Jie Xue, Heng-bin Wang. Osthole regulates hepatic PPARα-mediated lipogenic gene expression in alcoholic fatty liver murine. Phytomedicine,2010,17: 669-673. 7. Yinan Hua, Jie Xue, Fan Sun, Lujia Zhu, Meilin Xie*. Aspirin inhibits MMP-2 and MMP-9 expressions and activities through upregulation of PPARα/γ and TIMP gene expressions in ox-LDL-stimulated macrophages derived from human monocytes. Pharmacology, 2009,83(1):18-25. 8. Yiqin Yao, Meilin Xie*, Jie Xue, Keping Zhang. Aspirin inhibits MMP-2 and MMP-9 expression and activity through PPARα/γ and TIMP-1-mediated mechanisms in cultured mouse celiac macrophages. Inflammation, 2009,32:233-241. 9. Fan Sun, Meilin Xie, Lujia Zhu, Jie Xue, Zhenlun Gu. Inhibitory effect of osthole on alcohol-induced fatty liver in mice. Digestive and Liver Disease, 2009,41:127-133. 10.Yan Zhang, Mei-lin Xie*, Jie Xue, Zhen-lun Gu. Osthole regulates enzyme protein expression of CYP7A1 and DGAT2 via activation of PPARa/γ in fat milk-induced fatty liver rats. Journal of Asian Natural Products Research, 2008, 10 (8): 797-802. 11.Yan Zhang, Mei-lin Xie*, Jie Xue, Zhen-lun Gu. Osthole improves fat milk-induced fatty liver in rats: Modulation of hepatic PPAR-alpha/gamma-mediated lipogenic gene expression. Planta Medica, 2007,73(8): 718-724. 12.Yan Zhang, Mei-lin Xie*, Lu-jia Zhu, Zhen-lun Gu. Therapeutic effect of osthole on hyperlipidemic fatty liver in rats. Acta Pharmacologica Sinica 2007,28(3):398-403.