个人简介
隋广超教授，博士生导师，副院长。
教育和训练经历:
1983/09－1987/07，北京大学，生物系，生物化学专业学士
1990/10－1995/07，北京大学，生命科学学院，生物化学及分子生物学博士
1995/10－1998/11，瑞典Karolinska医学院，临床化学系，医学博士
1998/11－1999/07，瑞典Karolinska医学院，临床化学系，博士后
1999/07－2004/08，美国哈佛大学哈佛医学院，病理系，博士后
工作经历:
2004/09－2005/08，美国哈佛大学哈佛医学院，讲师
2005/09－2012/09，美国Wake Forest大学医学院癌症生物学系，美国NIH综合癌症研究中心，助教授
2012/10－2014/06，美国Wake Forest大学医学院癌症生物学系，美国NIH综合癌症研究中心，副教授
2014－现在，东北林业大学生命科学学院，教授(全职)
研究领域
利用分子生物学、细胞生物学和动物模型来研究癌症的发生与发展过程中的分子调控机制。
近期论文
查看导师新发文章
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1. Guang-Chao Sui, Hong Sun, Man Zhang and Mei-Hao Hu.High level expression of recombinant plasminogen activator inhibitor-1 in Escherichia coli and generation of its mutants involving Asp125, Glu128 and Glu130. (1997)Biochem. Mol. Biol. Int.,42(3):621-629.
2. Guang-Chao Suiand Bj?rn Wiman.Stability of plasminogen activator-1: role of Tyrosine221. (1998)FEBS Letters,423(3):319-323.
3. Guang-Chao Suiand Bj?rn Wiman.Functional effects of single amino acid substitutions in the region Phe113 to Asp138 in the PAI-1 molecule. (1998)Biochem. J.,331(2):409-415.
4. Gunnar Falk,Guang-Chao Sui, Sam Schulman and Bj?rn Wiman.Detection of a new polymorphism in the propeptide region of the PAI-1 gene in two individuals with bleeding tendencies. (1999)Fibrinolysis and Proteolysis,13(1):26-30.
5. Guang-Chao Sui, Helena M?ngs and Bj?rn Wiman.The role of His143 to PAI-1 function. (1999)Biochim. Biophys. Acta.,1434(1):58-63.
6. Helena M?ngs,Guang-Chao Suiand Bj?rn Wiman.PAI-1 stability: role of histidine residues. (2000)FEBS Letters,475(3):192-196.
7. Guang-Chao Suiand Bj?rn Wiman.The B beta-sheet in the PAI-1 molecule plays an important role in regulating its stability. (2000)Thrombosis and Haemostasis,83(6):896-901.http://www.schattauer.de/index.php?id=1268&L=1&pii=th00060896&no_cache=1
8. Dominica Calvo, Martin Vector, Frederique Gay,Guangchao Sui, Margaret P Luck, Pascle Dufourcq, Gengyun Wen, M Maduro, J Rothman and Yang Shi.A POP-1 repressor complex restricts inappropriate cell type-specific gene transcription during Caenorhabditis elegans embryogenesis. (2001)EMBO. J.,20(24):7197-7208.
9. Guangchao Sui, Christina Soohoo, El Bachir Affar, Frederique Gay, Yujiang Shi, William C. Forrester, and Yang Shi.A DNA vector-based RNAi technology to suppress gene expression in mammalian cells. (2002)Proc. Natl. Acad. Sci. USA,99:5515-5520.
10. Yujiang Shi, Junichi Sawada,Guangchao Sui, El Bachir Affar, Johnathan R. Whetstine, Fei Lan, Hidesato Ogawa, Margaret Po-Shan Luke, Yoshihiro Nakatani and Yang Shi.Coordinated histone modifications mediated by a CtBP co-repressor complex. (2003)Nature, 422:735-738.
11. Guangchao Sui, El Bachir Affar, Yujiang Shi, Chrystelle Brignone, Nathan R. Wall, Peng Yin, Mary Donohoe, Margaret P. Luke, Dominica Calvo, Steven R. Grossman and Yang Shi.Yin Yang 1 is a negative regulator of p53. (2004)Cell,117:859-872.
12. Peter Baumeister, Shengzhan Luo, William C. Skarnes,Guangchao Sui,Edward Seto, Yang Shi and Amy S. Lee.Endoplasmic reticulum stress induction of the Grp78/BiP promoter: activating mechanisms mediated by YY1 and its interactive chromatin modifiers. (2005)Mol. Cell. Biol., 25:4529-4540.
13. Guangchao Suiand Yang Shi.Gene silencing by a DNA vector-based RNAi technology. (2005)Methods Mol. Biol.,309:205-218.
14. El Bachir Affar, Margaret Po-shan Luke, Frederique Gay, Dominica, Calvo,Guangchao Sui, Robert S. Weiss, En Li, and Yang Shi.Targeted ablation of Par-4 reveals a cell type-specific susceptibility to apoptosis-inducing agents. (2006)Cancer Research. 66:3456-3462.
15. Margaret P. Luke,Guangchao Sui, Huifei Liu and Yang Shi.Yin Yang 1 physically interacts with HoxA11 and represses HoxA11-depedent transcription. (2006)J. Biol. Chem.,281:33226-33232.
16. Zhiyong Deng, Meimei Wan andGuangchao Sui*.PIASy-mediated sumoylation of Yin Yang 1 depends on their interaction but not the RING finger. (2007)Mol. Cell. Biol., 27(10):3780-3792.
17. Dohoon Kim, Minh Nguyen, Matthew Dobbin, Andre Fischer, Farahnaz Sananbenesi, Joseph Rodgers, Ivana Delalle, Joseph Baur,Guangchao Sui, Sean M Armour, Pere Puigserver, David Sinclair and Li-Huei Tsai.SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. (2007)EMBO J.26(13):3169–3179.
18. Zhiyong Deng, Meimei Wan, Paul Cao, Anuradha Rao, Scott D. Cramer andGuangchao Sui*. Yin Yang 1 Regulates the Transcriptional Activity of Androgen Receptor. (2009)Oncogene; 28:3746-3757.
19. Guangchao Sui*.The regulation of YY1 in tumorigenesis and its targeting potential in cancer therapy. (2009)Mol. Cell. Pharmacol. (Invited review)
20. Zhiyong Deng, Paul Cao, Meimei Wan andGuangchao Sui*.Yin Yang 1: a multifaceted protein beyond a transcription factor.(2010)Transcription. 1(2):81-84. (Invited review)
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